JP7699595B2 - 統合的ストレス応答経路の調節因子 - Google Patents

統合的ストレス応答経路の調節因子 Download PDF

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JP7699595B2
JP7699595B2 JP2022545799A JP2022545799A JP7699595B2 JP 7699595 B2 JP7699595 B2 JP 7699595B2 JP 2022545799 A JP2022545799 A JP 2022545799A JP 2022545799 A JP2022545799 A JP 2022545799A JP 7699595 B2 JP7699595 B2 JP 7699595B2
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alkyl
pharma
tautomer
hydrate
stereoisomer
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JP2023511616A5 (https=
JP2023511616A (ja
JPWO2021151865A5 (https=
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クリストファー・ジョン・ブラウン
ジェームズ・リンゼイ・カー
モハマド・サバ
ジェフリー・マイケル・シュケリャンツ
ダリル・シモン・ウォルター
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Evotec International GmbH
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
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  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
JP2022545799A 2020-01-28 2021-01-26 統合的ストレス応答経路の調節因子 Active JP7699595B2 (ja)

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Application Number Priority Date Filing Date Title
EP20154031.7 2020-01-28
EP20154031 2020-01-28
PCT/EP2021/051697 WO2021151865A1 (en) 2020-01-28 2021-01-26 Modulators of the integrated stress response pathway

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JP2023511616A JP2023511616A (ja) 2023-03-20
JP2023511616A5 JP2023511616A5 (https=) 2024-02-02
JPWO2021151865A5 JPWO2021151865A5 (https=) 2024-02-02
JP7699595B2 true JP7699595B2 (ja) 2025-06-27

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US (1) US20230125481A1 (https=)
EP (1) EP4096665A1 (https=)
JP (1) JP7699595B2 (https=)
KR (1) KR20220133252A (https=)
CN (1) CN114980894B (https=)
AU (1) AU2021213289A1 (https=)
BR (1) BR112022012643A2 (https=)
CA (1) CA3162526A1 (https=)
IL (1) IL294805A (https=)
MX (1) MX2022009243A (https=)
WO (1) WO2021151865A1 (https=)

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CN115190813B (zh) 2020-03-11 2024-10-15 埃沃特克国际有限责任公司 整合应激反应途径的调节剂
EP4232153A1 (en) 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
RS66455B1 (sr) 2020-10-22 2025-02-28 Evotec Int Gmbh Modulatori puta integrisanog odgovora na stres
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CN114980894A (zh) 2022-08-30
KR20220133252A (ko) 2022-10-04
CN114980894B (zh) 2024-10-18
AU2021213289A1 (en) 2022-07-07
BR112022012643A2 (pt) 2022-09-06
WO2021151865A1 (en) 2021-08-05
CA3162526A1 (en) 2021-08-05
EP4096665A1 (en) 2022-12-07
MX2022009243A (es) 2022-08-16
IL294805A (en) 2022-09-01
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