JP7698418B2 - Egfr活性化変異を有するがんを治療するための方法 - Google Patents
Egfr活性化変異を有するがんを治療するための方法 Download PDFInfo
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- JP7698418B2 JP7698418B2 JP2020548775A JP2020548775A JP7698418B2 JP 7698418 B2 JP7698418 B2 JP 7698418B2 JP 2020548775 A JP2020548775 A JP 2020548775A JP 2020548775 A JP2020548775 A JP 2020548775A JP 7698418 B2 JP7698418 B2 JP 7698418B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Animal Behavior & Ethology (AREA)
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- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025013551A JP2025069282A (ja) | 2018-03-13 | 2025-01-30 | Egfr活性化変異を有するがんを治療するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642472P | 2018-03-13 | 2018-03-13 | |
| US62/642,472 | 2018-03-13 | ||
| PCT/US2019/022067 WO2019178239A1 (en) | 2018-03-13 | 2019-03-13 | Methods for treatment of cancers with egfr activating mutations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025013551A Division JP2025069282A (ja) | 2018-03-13 | 2025-01-30 | Egfr活性化変異を有するがんを治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021517894A JP2021517894A (ja) | 2021-07-29 |
| JP2021517894A5 JP2021517894A5 (https=) | 2022-03-22 |
| JP7698418B2 true JP7698418B2 (ja) | 2025-06-25 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548775A Active JP7698418B2 (ja) | 2018-03-13 | 2019-03-13 | Egfr活性化変異を有するがんを治療するための方法 |
| JP2025013551A Withdrawn JP2025069282A (ja) | 2018-03-13 | 2025-01-30 | Egfr活性化変異を有するがんを治療するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025013551A Withdrawn JP2025069282A (ja) | 2018-03-13 | 2025-01-30 | Egfr活性化変異を有するがんを治療するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210015819A1 (https=) |
| JP (2) | JP7698418B2 (https=) |
| KR (1) | KR20200132902A (https=) |
| CN (1) | CN111867586A (https=) |
| WO (1) | WO2019178239A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105816437B (zh) | 2016-03-29 | 2018-08-03 | 深圳市药欣生物科技有限公司 | 一种帕布昔利布的药物制剂及其制备方法 |
| MX2021011948A (es) * | 2019-03-29 | 2022-01-04 | Univ Texas | Compuestos con actividad antitumoral contra células cancerígenas que llevan inserciones de exon 20 effr o her2. |
| EP4192463A1 (en) * | 2020-08-07 | 2023-06-14 | Hope Permanente, LLC | Use of cyclin-dependent kinase (cdk) inhibitors for the slowdown or prevention of biological aging |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
| CN114432454B (zh) * | 2022-03-21 | 2023-05-05 | 安徽大学 | Plk1抑制剂在制备治疗埃博拉病毒疾病的药物中的应用 |
| CN119137102A (zh) | 2022-04-08 | 2024-12-13 | 拜奥列司治疗有限公司 | Cdk9抑制剂 |
| CN117045660A (zh) * | 2022-04-22 | 2023-11-14 | 南京市儿童医院 | 一种plk1抑制剂在制备用于缓解肾脏纤维化药物中的用途 |
| WO2024192141A1 (en) * | 2023-03-13 | 2024-09-19 | Dana-Farber Cancer Institute, Inc. | Treatment of cancers having a drug-resistant mesenchymal cell state |
| WO2025245045A1 (en) * | 2024-05-21 | 2025-11-27 | The Regents Of The University Of California | Methods of treating lung cancer |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528695A (ja) | 2005-02-03 | 2008-07-31 | ザ ジェネラル ホスピタル コーポレーション | ゲフィチニブ耐性癌を治療する方法 |
| JP2009526009A (ja) | 2006-02-10 | 2009-07-16 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Cdk阻害剤、および成長因子抗体または抗有糸分裂剤を含む組合せ |
| JP2010523536A (ja) | 2007-04-04 | 2010-07-15 | サイクラセル リミテッド | プリンに基づくcdk阻害剤とチロシンキナーゼ阻害剤の組合せ、及び増殖性障害の治療におけるその使用 |
| US20110033461A1 (en) | 2008-03-12 | 2011-02-10 | Vladimir Ratushny | Combination Therapy for the Treatment of Cancer |
| JP2013519707A (ja) | 2010-02-19 | 2013-05-30 | ノバルティス アーゲー | Cdk4/6阻害剤としてのピロロピリミジン化合物 |
| JP2014141530A (ja) | 2007-04-13 | 2014-08-07 | Dana Farber Cancer Institute Inc | ErbB療法に耐性である癌を治療するための方法 |
| JP2018090566A (ja) | 2016-11-16 | 2018-06-14 | ファイザー・インク | 非小細胞肺癌の治療のためのegfr t790m阻害剤およびcdk阻害剤の組合せ |
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| US8399442B2 (en) * | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
| EP2224919A4 (en) * | 2007-11-28 | 2011-09-14 | Tragara Pharmaceuticals Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS AND TUMOR-RELATED DISEASES |
| US20140155397A1 (en) * | 2011-04-01 | 2014-06-05 | Board Of Regents | Emt signatures and predictive markers and method of using the same |
| PL2838998T3 (pl) * | 2012-04-18 | 2018-04-30 | Cell Signaling Technology, Inc. | EGFR i ROS1 w nowotworze |
| BR102013027577A2 (pt) * | 2012-10-25 | 2016-03-29 | Memorialsloan Kettering Cancer Ct | método de detecção de um nível aumentado de axl ou gas6 e método de identificação de um paciente com câncer resistente a inibidor de egfr |
| WO2015095840A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of cdk and erk inhibitors |
| WO2015112705A2 (en) * | 2014-01-24 | 2015-07-30 | Clovis Oncology, Inc. | Therapeutic combinations for treating cancer |
| US20160346240A1 (en) * | 2014-02-03 | 2016-12-01 | Quadriga Biosciences, Inc. | Methods of chemotherapy using chemotherapeutic agents based on beta-substituted beta-amino acids and analogs |
| US10555931B2 (en) * | 2014-05-28 | 2020-02-11 | Piramal Enterprises Limited | Pharmaceutical combination for the treatment of cancer |
| WO2016201370A1 (en) * | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| US10240145B2 (en) * | 2015-11-25 | 2019-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer |
| GB201612520D0 (en) * | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| EP3585389A4 (en) * | 2017-02-22 | 2020-12-23 | G1 Therapeutics, Inc. | EGFR-CAUSED CANCER TREATMENT WITH LESS SIDE EFFECTS |
| WO2019090332A1 (en) * | 2017-11-06 | 2019-05-09 | Tiziana Life Sciences Plc | Formulations of milciclib and therapeutic combinations of the same for use in the treatment of cancer |
-
2019
- 2019-03-13 WO PCT/US2019/022067 patent/WO2019178239A1/en not_active Ceased
- 2019-03-13 JP JP2020548775A patent/JP7698418B2/ja active Active
- 2019-03-13 US US16/980,079 patent/US20210015819A1/en active Pending
- 2019-03-13 CN CN201980018745.1A patent/CN111867586A/zh active Pending
- 2019-03-13 KR KR1020207028689A patent/KR20200132902A/ko not_active Ceased
-
2025
- 2025-01-30 JP JP2025013551A patent/JP2025069282A/ja not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528695A (ja) | 2005-02-03 | 2008-07-31 | ザ ジェネラル ホスピタル コーポレーション | ゲフィチニブ耐性癌を治療する方法 |
| JP2009526009A (ja) | 2006-02-10 | 2009-07-16 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Cdk阻害剤、および成長因子抗体または抗有糸分裂剤を含む組合せ |
| JP2010523536A (ja) | 2007-04-04 | 2010-07-15 | サイクラセル リミテッド | プリンに基づくcdk阻害剤とチロシンキナーゼ阻害剤の組合せ、及び増殖性障害の治療におけるその使用 |
| JP2014141530A (ja) | 2007-04-13 | 2014-08-07 | Dana Farber Cancer Institute Inc | ErbB療法に耐性である癌を治療するための方法 |
| US20110033461A1 (en) | 2008-03-12 | 2011-02-10 | Vladimir Ratushny | Combination Therapy for the Treatment of Cancer |
| JP2013519707A (ja) | 2010-02-19 | 2013-05-30 | ノバルティス アーゲー | Cdk4/6阻害剤としてのピロロピリミジン化合物 |
| JP2018090566A (ja) | 2016-11-16 | 2018-06-14 | ファイザー・インク | 非小細胞肺癌の治療のためのegfr t790m阻害剤およびcdk阻害剤の組合せ |
Non-Patent Citations (4)
| Title |
|---|
| Cancer Res, 2006, Vol.66, No.23, pp.11389-11398,doi:10.1158/0008-5472.CAN-06-2318 |
| Ching-Chuan Ku, et al.,Mol. Cancer Ther.,Abstract A171: Targeting tumor metabolism by novel EGFR inhibitor in head and neckcancer,2015年,Vol.14, No.12, Supplement_2,Abstract No.A171,https://doi.org/10.1158/1535-7163.TARG-15-A171 |
| Journal of Thoracic Oncology, 2017, Vol.12, No.11S1, p.S1582 |
| Molecular Cancer Therapeutics, 2012, Vol.Vol.11, No.1, pp.204-213,doi: 10.1158/1535-7163.MCT-11-0638 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021517894A (ja) | 2021-07-29 |
| CN111867586A (zh) | 2020-10-30 |
| JP2025069282A (ja) | 2025-04-30 |
| WO2019178239A1 (en) | 2019-09-19 |
| US20210015819A1 (en) | 2021-01-21 |
| KR20200132902A (ko) | 2020-11-25 |
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