JP7680365B2 - 血漿中の膵管腺癌の検出 - Google Patents

血漿中の膵管腺癌の検出 Download PDF

Info

Publication number
JP7680365B2
JP7680365B2 JP2021559250A JP2021559250A JP7680365B2 JP 7680365 B2 JP7680365 B2 JP 7680365B2 JP 2021559250 A JP2021559250 A JP 2021559250A JP 2021559250 A JP2021559250 A JP 2021559250A JP 7680365 B2 JP7680365 B2 JP 7680365B2
Authority
JP
Japan
Prior art keywords
methylation
primers
chromosome
dna
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021559250A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022526415A5 (enExample
JP2022526415A (ja
Inventor
アール． テイラー，ウィリアム
ビー． キシエル，ジョン
ダブリュー． マホーニー，ダグラス
エー． アールクィスト，デビッド
ティー． アッラーウィー，ハティム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Clinic in Florida
Original Assignee
Mayo Clinic in Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Clinic in Florida filed Critical Mayo Clinic in Florida
Publication of JP2022526415A publication Critical patent/JP2022526415A/ja
Publication of JP2022526415A5 publication Critical patent/JP2022526415A5/ja
Priority to JP2025006056A priority Critical patent/JP2025063204A/ja
Application granted granted Critical
Publication of JP7680365B2 publication Critical patent/JP7680365B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Gastroenterology & Hepatology (AREA)
JP2021559250A 2019-04-03 2020-04-03 血漿中の膵管腺癌の検出 Active JP7680365B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025006056A JP2025063204A (ja) 2019-04-03 2025-01-16 血漿中の膵管腺癌の検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962828948P 2019-04-03 2019-04-03
US62/828,948 2019-04-03
PCT/US2020/026581 WO2020206256A1 (en) 2019-04-03 2020-04-03 Detecting pancreatic ductal adenocarcinoma in plasma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025006056A Division JP2025063204A (ja) 2019-04-03 2025-01-16 血漿中の膵管腺癌の検出

Publications (3)

Publication Number Publication Date
JP2022526415A JP2022526415A (ja) 2022-05-24
JP2022526415A5 JP2022526415A5 (enExample) 2023-04-11
JP7680365B2 true JP7680365B2 (ja) 2025-05-20

Family

ID=72667410

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021559250A Active JP7680365B2 (ja) 2019-04-03 2020-04-03 血漿中の膵管腺癌の検出
JP2025006056A Pending JP2025063204A (ja) 2019-04-03 2025-01-16 血漿中の膵管腺癌の検出

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025006056A Pending JP2025063204A (ja) 2019-04-03 2025-01-16 血漿中の膵管腺癌の検出

Country Status (8)

Country Link
US (1) US20220162709A1 (enExample)
EP (1) EP3948292A4 (enExample)
JP (2) JP7680365B2 (enExample)
KR (1) KR20210146983A (enExample)
CN (2) CN119082301A (enExample)
AU (1) AU2020254760B2 (enExample)
CA (1) CA3132182A1 (enExample)
WO (1) WO2020206256A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
CN120700143A (zh) 2014-03-31 2025-09-26 梅奥医学教育和研究基金会 检测结直肠赘生物
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
CN109563546B (zh) 2016-05-05 2022-09-09 精密科学发展有限责任公司 通过分析甲基化dna来检测肺肿瘤
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
US11702704B2 (en) 2019-10-31 2023-07-18 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
CN115605138A (zh) 2020-04-17 2023-01-13 精密科学公司（Us） 可摄取取样装置
KR20230150814A (ko) * 2021-01-29 2023-10-31 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 다양한 유형의 암에 대한 존재 또는 부재의 검출
WO2026055641A1 (en) 2024-09-06 2026-03-12 Exact Sciences Corporation Methods and compositions for preparing biomolecule analytes from complex samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274748A1 (en) 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US20160090634A1 (en) 2014-09-26 2016-03-31 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US20160251727A1 (en) 2015-02-27 2016-09-01 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US20160340740A1 (en) 2014-01-30 2016-11-24 The Regents Of The University Of California Methylation haplotyping for non-invasive diagnosis (monod)
WO2017180886A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1554407B1 (en) * 2002-10-01 2009-07-29 Epigenomics AG Method for the treatment of breast cell proliferative disorders
CA2549852A1 (en) * 2003-12-11 2005-06-30 Epigenomics Ag Method and nucleic acids for the improved treatment of breast cell proliferative disorders
US8158356B2 (en) * 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
DK2082745T3 (da) * 2007-12-28 2013-03-25 Deutsches Krebsforsch Kræftterapi med en parvovirus kombineret med kemoterapi
US9012723B2 (en) * 2009-01-16 2015-04-21 Monsanto Technology Llc Isolated novel acid and protein molecules from soy and methods of using those molecules to generate transgene plants with enhanced agronomic traits
US9828585B2 (en) * 2011-08-30 2017-11-28 The J. David Gladstone Instututes Methods for generating cardiomyocytes
WO2014051522A1 (en) * 2012-09-26 2014-04-03 Agency For Science, Technology And Research Biomarkers for down syndrome prenatal diagnosis
US20140274757A1 (en) * 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer
CN114574585A (zh) * 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
CN109563546B (zh) * 2016-05-05 2022-09-09 精密科学发展有限责任公司 通过分析甲基化dna来检测肺肿瘤
EP3507298B1 (en) * 2016-09-02 2023-08-30 Mayo Foundation for Medical Education and Research Detecting hepatocellular carcinoma
KR102892245B1 (ko) * 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
CA3127329A1 (en) * 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274748A1 (en) 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US20160340740A1 (en) 2014-01-30 2016-11-24 The Regents Of The University Of California Methylation haplotyping for non-invasive diagnosis (monod)
US20160090634A1 (en) 2014-09-26 2016-03-31 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US20160251727A1 (en) 2015-02-27 2016-09-01 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
WO2017180886A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KISIEL, John B. et al.，"New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice"，Clinical Cancer Research，2015年09月30日，Vol. 21，No. 19，pp.4473-4481，DOI: 10.1158/1078-0432.CCR-14-2469

Also Published As

Publication number Publication date
AU2020254760A1 (en) 2021-10-28
CA3132182A1 (en) 2020-10-08
US20220162709A1 (en) 2022-05-26
CN119082301A (zh) 2024-12-06
EP3948292A1 (en) 2022-02-09
EP3948292A4 (en) 2023-01-18
JP2025063204A (ja) 2025-04-15
CN113811622A (zh) 2021-12-17
JP2022526415A (ja) 2022-05-24
AU2020254760B2 (en) 2025-10-23
KR20210146983A (ko) 2021-12-06
CN113811622B (zh) 2024-09-17
WO2020206256A1 (en) 2020-10-08

Similar Documents

Publication Publication Date Title
JP7680365B2 (ja) 血漿中の膵管腺癌の検出
JP7771126B2 (ja) 胃の新生物を検出すること
JP7704792B2 (ja) 肝細胞癌の検出
JP7799607B2 (ja) 卵巣癌の検出
US20230028856A1 (en) Detecting gastrointestinal neoplasms
US11697853B2 (en) Detecting prostate cancer
US12584177B2 (en) Detecting endometrial cancer
JP2025106467A (ja) 乳癌の検出
KR20230049122A (ko) 비호지킨 림프종의 검출
JP2025029006A (ja) メラノーマの検出

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230403

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230403

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240319

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240610

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240917

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250116

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250415

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250508

R150 Certificate of patent or registration of utility model

Ref document number: 7680365

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150