JP7677964B2 - ヘテロＩｇＧ分子の対合のための電荷対変異の操作 - Google Patents

ヘテロＩｇＧ分子の対合のための電荷対変異の操作 Download PDF

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JP7677964B2
JP7677964B2 JP2022525717A JP2022525717A JP7677964B2 JP 7677964 B2 JP7677964 B2 JP 7677964B2 JP 2022525717 A JP2022525717 A JP 2022525717A JP 2022525717 A JP2022525717 A JP 2022525717A JP 7677964 B2 JP7677964 B2 JP 7677964B2
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amino acid
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region
acid modification
antibody
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JP2022553813A (ja
JPWO2021092355A5 (https=
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エステス，ブラム
ガルセス，フェルナンド
ワン，ジュウルン
ダリス，マーク
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022525717A 2019-11-08 2020-11-06 ヘテロＩｇＧ分子の対合のための電荷対変異の操作 Active JP7677964B2 (ja)

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JP2025076140A JP2025118753A (ja) 2019-11-08 2025-05-01 ヘテロＩｇＧ分子の対合のための電荷対変異の操作

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US201962933205P 2019-11-08 2019-11-08
US62/933,205 2019-11-08
PCT/US2020/059378 WO2021092355A1 (en) 2019-11-08 2020-11-06 Engineering charge pair mutations for pairing of hetero-igg molecules

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JP2022553813A JP2022553813A (ja) 2022-12-26
JPWO2021092355A5 JPWO2021092355A5 (https=) 2023-11-14
JP2022553813A5 JP2022553813A5 (https=) 2023-11-14
JP7677964B2 true JP7677964B2 (ja) 2025-05-15

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JP2025076140A Pending JP2025118753A (ja) 2019-11-08 2025-05-01 ヘテロＩｇＧ分子の対合のための電荷対変異の操作

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US (1) US20220389119A1 (https=)
EP (2) EP4628498A3 (https=)
JP (2) JP7677964B2 (https=)
AU (1) AU2020380379A1 (https=)
CA (1) CA3160482A1 (https=)
ES (1) ES3040852T3 (https=)
MX (1) MX2022005566A (https=)
WO (1) WO2021092355A1 (https=)

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WO2025137454A1 (en) 2023-12-21 2025-06-26 Amgen Inc. Stabilizing homodimer mutations for two cell heterodimer production

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JP2019033743A (ja) 2017-08-03 2019-03-07 アムジエン・インコーポレーテツド インターロイキン−２１ムテイン及び治療方法
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EP4055060A1 (en) 2022-09-14
EP4628498A3 (en) 2026-03-04
JP2022553813A (ja) 2022-12-26
EP4628498A2 (en) 2025-10-08
CA3160482A1 (en) 2021-05-14
ES3040852T3 (en) 2025-11-05
MX2022005566A (es) 2022-07-19
US20220389119A1 (en) 2022-12-08
JP2025118753A (ja) 2025-08-13
EP4055060C0 (en) 2025-07-09
WO2021092355A1 (en) 2021-05-14
AU2020380379A1 (en) 2022-05-26
EP4055060B1 (en) 2025-07-09

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