ES3040852T3 - Engineering charge pair mutations for pairing of hetero-igg molecules - Google Patents

Engineering charge pair mutations for pairing of hetero-igg molecules

Info

Publication number
ES3040852T3
ES3040852T3 ES20820597T ES20820597T ES3040852T3 ES 3040852 T3 ES3040852 T3 ES 3040852T3 ES 20820597 T ES20820597 T ES 20820597T ES 20820597 T ES20820597 T ES 20820597T ES 3040852 T3 ES3040852 T3 ES 3040852T3
Authority
ES
Spain
Prior art keywords
amino acid
domain
antigen
region
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20820597T
Other languages
English (en)
Spanish (es)
Inventor
Bram Estes
Fernando Garces
Zhulun Wang
Mark Daris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ES3040852T3 publication Critical patent/ES3040852T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES20820597T 2019-11-08 2020-11-06 Engineering charge pair mutations for pairing of hetero-igg molecules Active ES3040852T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962933205P 2019-11-08 2019-11-08
PCT/US2020/059378 WO2021092355A1 (en) 2019-11-08 2020-11-06 Engineering charge pair mutations for pairing of hetero-igg molecules

Publications (1)

Publication Number Publication Date
ES3040852T3 true ES3040852T3 (en) 2025-11-05

Family

ID=73740489

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20820597T Active ES3040852T3 (en) 2019-11-08 2020-11-06 Engineering charge pair mutations for pairing of hetero-igg molecules

Country Status (8)

Country Link
US (1) US20220389119A1 (https=)
EP (2) EP4628498A3 (https=)
JP (2) JP7677964B2 (https=)
AU (1) AU2020380379A1 (https=)
CA (1) CA3160482A1 (https=)
ES (1) ES3040852T3 (https=)
MX (1) MX2022005566A (https=)
WO (1) WO2021092355A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025137454A1 (en) 2023-12-21 2025-06-26 Amgen Inc. Stabilizing homodimer mutations for two cell heterodimer production

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Also Published As

Publication number Publication date
EP4055060A1 (en) 2022-09-14
EP4628498A3 (en) 2026-03-04
JP2022553813A (ja) 2022-12-26
EP4628498A2 (en) 2025-10-08
CA3160482A1 (en) 2021-05-14
MX2022005566A (es) 2022-07-19
US20220389119A1 (en) 2022-12-08
JP2025118753A (ja) 2025-08-13
EP4055060C0 (en) 2025-07-09
JP7677964B2 (ja) 2025-05-15
WO2021092355A1 (en) 2021-05-14
AU2020380379A1 (en) 2022-05-26
EP4055060B1 (en) 2025-07-09

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