JP7674077B2 - 翻訳可能分子およびその合成 - Google Patents

翻訳可能分子およびその合成 Download PDF

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Publication number
JP7674077B2
JP7674077B2 JP2019546855A JP2019546855A JP7674077B2 JP 7674077 B2 JP7674077 B2 JP 7674077B2 JP 2019546855 A JP2019546855 A JP 2019546855A JP 2019546855 A JP2019546855 A JP 2019546855A JP 7674077 B2 JP7674077 B2 JP 7674077B2
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mrna
template
translatable
rna
molecules
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Japanese (ja)
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JP2020510426A5 (https=
JP2020510426A (ja
Inventor
リンフォン パトララニー・
キヨシ・タチカワ
パドマナブ・チブクラ
ダイキ・マツダ
アリサ・ケイル
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Arcturus Therapeutics Inc
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Arcturus Therapeutics Inc
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Priority to JP2022209557A priority Critical patent/JP2023052106A/ja
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Priority to JP2025159744A priority patent/JP2026016392A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019546855A 2017-02-28 2018-02-27 翻訳可能分子およびその合成 Active JP7674077B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022209557A JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成
JP2025159744A JP2026016392A (ja) 2017-02-28 2025-09-26 翻訳可能分子およびその合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762465073P 2017-02-28 2017-02-28
US62/465,073 2017-02-28
PCT/US2018/020018 WO2018160592A1 (en) 2017-02-28 2018-02-27 Translatable molecules and synthesis thereof

Related Child Applications (1)

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JP2022209557A Division JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成

Publications (3)

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JP2020510426A JP2020510426A (ja) 2020-04-09
JP2020510426A5 JP2020510426A5 (https=) 2021-04-15
JP7674077B2 true JP7674077B2 (ja) 2025-05-09

Family

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JP2019546855A Active JP7674077B2 (ja) 2017-02-28 2018-02-27 翻訳可能分子およびその合成
JP2022209557A Pending JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成
JP2025159744A Pending JP2026016392A (ja) 2017-02-28 2025-09-26 翻訳可能分子およびその合成

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JP2022209557A Pending JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成
JP2025159744A Pending JP2026016392A (ja) 2017-02-28 2025-09-26 翻訳可能分子およびその合成

Country Status (4)

Country Link
US (2) US11407800B2 (https=)
EP (1) EP3589290A4 (https=)
JP (3) JP7674077B2 (https=)
WO (1) WO2018160592A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11407800B2 (en) 2017-02-28 2022-08-09 Arcturus Therapeutics, Inc. Translatable molecules and synthesis thereof
AU2019394996B2 (en) 2018-12-06 2025-11-06 Arcturus Therapeutics, Inc. Compositions and methods for treating ornithine transcarbamylase deficiency
CN110331147A (zh) * 2019-06-21 2019-10-15 苏州吉玛基因股份有限公司 一种mRNA的制备方法及其在肿瘤治疗中的应用
US12351834B2 (en) 2020-03-03 2025-07-08 Arcturus Therapeutics, Inc. Compositions and methods for the treatment of ornithine transcarbamylase deficiency
AU2021236068A1 (en) 2020-03-09 2022-10-06 Arcturus Therapeutics, Inc. Compositions and methods for inducing immune responses
CA3176844A1 (en) 2020-05-01 2021-11-04 Carlos G. PEREZ-GARCIA Nucleic acids and methods of treatment for cystic fibrosis
EP4196128A4 (en) 2020-08-14 2024-06-12 Arcturus Therapeutics, Inc. METHOD FOR FREEZE DILIZATION OF LIPID NANOPARTICLES
CA3128660A1 (en) * 2020-10-09 2022-04-09 Eric G. Marcusson Compositions and methods for the prevention and/or treatment of covid-19
CN113372432A (zh) * 2021-06-15 2021-09-10 深圳市臻质医疗科技有限公司 一种基于化学修饰mRNA编码蛋白因子诱导和/或增强软骨损伤修复的方法
KR102785258B1 (ko) * 2022-09-07 2025-03-26 아이진 주식회사 변형핵산 함유 mRNA의 체내 전달용 조성물
EP4356933A1 (en) * 2022-09-07 2024-04-24 Eyegene, Inc. Composition for delivering modified nucleic acid-containing mrna

Citations (4)

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JP2015534817A (ja) 2012-11-01 2015-12-07 ファクター バイオサイエンス インコーポレイテッド 細胞中でタンパク質を発現するための方法および生成物
JP2015535430A (ja) 2012-11-26 2015-12-14 モデルナ セラピューティクス インコーポレイテッドＭｏ 末端修飾ｒｎａ
US20160237134A1 (en) 2014-11-10 2016-08-18 Moderna Therapeutics, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
JP2016527908A (ja) 2013-08-21 2016-09-15 キュアバック アーゲー Ｒｎａコードされたタンパク質の発現を促進するための方法

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ES2340499T3 (es) 2001-06-05 2010-06-04 Curevac Gmbh Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado.
AU2002338926B2 (en) * 2001-11-05 2007-05-24 Janssen Pharmaceutica N.V. Method for the in vitro synthesis of short double stranded RNAs
PL2578685T3 (pl) 2005-08-23 2020-01-31 The Trustees Of The University Of Pennsylvania Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
US8304529B2 (en) 2006-07-28 2012-11-06 Life Technologies Corporation Dinucleotide MRNA cap analogs
WO2009058911A2 (en) 2007-10-31 2009-05-07 Applied Biosystems Inc. Preparation and isolation of 5' capped mrna
US20090226906A1 (en) * 2008-03-05 2009-09-10 Helicos Biosciences Corporation Methods and compositions for reducing nucleotide impurities
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
US9283287B2 (en) * 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
EP3052511A4 (en) 2013-10-02 2017-05-31 Moderna Therapeutics, Inc. Polynucleotide molecules and uses thereof
JP6506749B2 (ja) 2013-10-22 2019-04-24 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド フェニルケトン尿症のためのｍＲＮＡ療法
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JP2015534817A (ja) 2012-11-01 2015-12-07 ファクター バイオサイエンス インコーポレイテッド 細胞中でタンパク質を発現するための方法および生成物
JP2015535430A (ja) 2012-11-26 2015-12-14 モデルナ セラピューティクス インコーポレイテッドＭｏ 末端修飾ｒｎａ
JP2016527908A (ja) 2013-08-21 2016-09-15 キュアバック アーゲー Ｒｎａコードされたタンパク質の発現を促進するための方法
US20160237134A1 (en) 2014-11-10 2016-08-18 Moderna Therapeutics, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof

Non-Patent Citations (1)

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Title
Bioconjugate Chemistry, 2016年, 発行日, Vol.27, pp.849-853

Also Published As

Publication number Publication date
WO2018160592A1 (en) 2018-09-07
JP2023052106A (ja) 2023-04-11
JP2026016392A (ja) 2026-02-03
US11407800B2 (en) 2022-08-09
US20180327471A1 (en) 2018-11-15
JP2020510426A (ja) 2020-04-09
US11939363B2 (en) 2024-03-26
EP3589290A1 (en) 2020-01-08
EP3589290A4 (en) 2020-12-30
US20230059111A1 (en) 2023-02-23

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