JP2020510426A5 - - Google Patents

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Publication number
JP2020510426A5
JP2020510426A5 JP2019546855A JP2019546855A JP2020510426A5 JP 2020510426 A5 JP2020510426 A5 JP 2020510426A5 JP 2019546855 A JP2019546855 A JP 2019546855A JP 2019546855 A JP2019546855 A JP 2019546855A JP 2020510426 A5 JP2020510426 A5 JP 2020510426A5
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JP
Japan
Prior art keywords
rna
region
protein
mrna
coding
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Application number
JP2019546855A
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English (en)
Japanese (ja)
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JP7674077B2 (ja
JP2020510426A (ja
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Priority claimed from PCT/US2018/020018 external-priority patent/WO2018160592A1/en
Publication of JP2020510426A publication Critical patent/JP2020510426A/ja
Publication of JP2020510426A5 publication Critical patent/JP2020510426A5/ja
Priority to JP2022209557A priority Critical patent/JP2023052106A/ja
Application granted granted Critical
Publication of JP7674077B2 publication Critical patent/JP7674077B2/ja
Priority to JP2025159744A priority patent/JP2026016392A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2019546855A 2017-02-28 2018-02-27 翻訳可能分子およびその合成 Active JP7674077B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022209557A JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成
JP2025159744A JP2026016392A (ja) 2017-02-28 2025-09-26 翻訳可能分子およびその合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762465073P 2017-02-28 2017-02-28
US62/465,073 2017-02-28
PCT/US2018/020018 WO2018160592A1 (en) 2017-02-28 2018-02-27 Translatable molecules and synthesis thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022209557A Division JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成

Publications (3)

Publication Number Publication Date
JP2020510426A JP2020510426A (ja) 2020-04-09
JP2020510426A5 true JP2020510426A5 (https=) 2021-04-15
JP7674077B2 JP7674077B2 (ja) 2025-05-09

Family

ID=63370513

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019546855A Active JP7674077B2 (ja) 2017-02-28 2018-02-27 翻訳可能分子およびその合成
JP2022209557A Pending JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成
JP2025159744A Pending JP2026016392A (ja) 2017-02-28 2025-09-26 翻訳可能分子およびその合成

Family Applications After (2)

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JP2022209557A Pending JP2023052106A (ja) 2017-02-28 2022-12-27 翻訳可能分子およびその合成
JP2025159744A Pending JP2026016392A (ja) 2017-02-28 2025-09-26 翻訳可能分子およびその合成

Country Status (4)

Country Link
US (2) US11407800B2 (https=)
EP (1) EP3589290A4 (https=)
JP (3) JP7674077B2 (https=)
WO (1) WO2018160592A1 (https=)

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US11407800B2 (en) 2017-02-28 2022-08-09 Arcturus Therapeutics, Inc. Translatable molecules and synthesis thereof
AU2019394996B2 (en) 2018-12-06 2025-11-06 Arcturus Therapeutics, Inc. Compositions and methods for treating ornithine transcarbamylase deficiency
CN110331147A (zh) * 2019-06-21 2019-10-15 苏州吉玛基因股份有限公司 一种mRNA的制备方法及其在肿瘤治疗中的应用
US12351834B2 (en) 2020-03-03 2025-07-08 Arcturus Therapeutics, Inc. Compositions and methods for the treatment of ornithine transcarbamylase deficiency
AU2021236068A1 (en) 2020-03-09 2022-10-06 Arcturus Therapeutics, Inc. Compositions and methods for inducing immune responses
CA3176844A1 (en) 2020-05-01 2021-11-04 Carlos G. PEREZ-GARCIA Nucleic acids and methods of treatment for cystic fibrosis
EP4196128A4 (en) 2020-08-14 2024-06-12 Arcturus Therapeutics, Inc. METHOD FOR FREEZE DILIZATION OF LIPID NANOPARTICLES
CA3128660A1 (en) * 2020-10-09 2022-04-09 Eric G. Marcusson Compositions and methods for the prevention and/or treatment of covid-19
CN113372432A (zh) * 2021-06-15 2021-09-10 深圳市臻质医疗科技有限公司 一种基于化学修饰mRNA编码蛋白因子诱导和/或增强软骨损伤修复的方法
KR102785258B1 (ko) * 2022-09-07 2025-03-26 아이진 주식회사 변형핵산 함유 mRNA의 체내 전달용 조성물
EP4356933A1 (en) * 2022-09-07 2024-04-24 Eyegene, Inc. Composition for delivering modified nucleic acid-containing mrna

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ES2340499T3 (es) 2001-06-05 2010-06-04 Curevac Gmbh Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado.
AU2002338926B2 (en) * 2001-11-05 2007-05-24 Janssen Pharmaceutica N.V. Method for the in vitro synthesis of short double stranded RNAs
PL2578685T3 (pl) 2005-08-23 2020-01-31 The Trustees Of The University Of Pennsylvania Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
US8304529B2 (en) 2006-07-28 2012-11-06 Life Technologies Corporation Dinucleotide MRNA cap analogs
WO2009058911A2 (en) 2007-10-31 2009-05-07 Applied Biosystems Inc. Preparation and isolation of 5' capped mrna
US20090226906A1 (en) * 2008-03-05 2009-09-10 Helicos Biosciences Corporation Methods and compositions for reducing nucleotide impurities
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
US9283287B2 (en) * 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
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KR102121086B1 (ko) * 2012-11-01 2020-06-09 팩터 바이오사이언스 인크. 세포에서 단백질을 발현시키는 방법들과 생성물들
PL2922554T3 (pl) * 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
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EP3052511A4 (en) 2013-10-02 2017-05-31 Moderna Therapeutics, Inc. Polynucleotide molecules and uses thereof
JP6506749B2 (ja) 2013-10-22 2019-04-24 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド フェニルケトン尿症のためのｍＲＮＡ療法
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US11407800B2 (en) 2017-02-28 2022-08-09 Arcturus Therapeutics, Inc. Translatable molecules and synthesis thereof

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