JP7671982B2 - ＨＳＶ－２－ＤＥＬＴＡ－ｇＤ ワクチンおよびそれらの生産および使用のための方法 - Google Patents

ＨＳＶ－２－ＤＥＬＴＡ－ｇＤ ワクチンおよびそれらの生産および使用のための方法 Download PDF

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JP7671982B2
JP7671982B2 JP2021510271A JP2021510271A JP7671982B2 JP 7671982 B2 JP7671982 B2 JP 7671982B2 JP 2021510271 A JP2021510271 A JP 2021510271A JP 2021510271 A JP2021510271 A JP 2021510271A JP 7671982 B2 JP7671982 B2 JP 7671982B2
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hsv
δgd
cells
rfp
mice
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JP2021522854A (ja
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ウィリアム・ジェイコブズ
ベッツィ・ヘロルド
ジョセフ・ダーディック
ケイラ・エイ・ワイス
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Albert Einstein College of Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C—CHEMISTRY; METALLURGY
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2021510271A 2018-05-01 2019-05-01 ＨＳＶ－２－ＤＥＬＴＡ－ｇＤ ワクチンおよびそれらの生産および使用のための方法 Active JP7671982B2 (ja)

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JP2024195785A JP2025032104A (ja) 2018-05-01 2024-11-08 ＨＳＶ－２－ＤＥＬＴＡ－ｇＤ ワクチンおよびそれらの生産および使用のための方法

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US201862665050P 2018-05-01 2018-05-01
US62/665,050 2018-05-01
PCT/US2019/030259 WO2019213305A1 (en) 2018-05-01 2019-05-01 HSV-2-DELTA-gD VACCINES AND METHODS FOR THEIR PRODUCTION AND USE

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JP2024195785A Division JP2025032104A (ja) 2018-05-01 2024-11-08 ＨＳＶ－２－ＤＥＬＴＡ－ｇＤ ワクチンおよびそれらの生産および使用のための方法

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JP2021522854A JP2021522854A (ja) 2021-09-02
JP2021522854A5 JP2021522854A5 (https=) 2022-05-09
JP7671982B2 true JP7671982B2 (ja) 2025-05-07

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JP2024195785A Pending JP2025032104A (ja) 2018-05-01 2024-11-08 ＨＳＶ－２－ＤＥＬＴＡ－ｇＤ ワクチンおよびそれらの生産および使用のための方法

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US (2) US20210236625A1 (https=)
EP (1) EP3787680A4 (https=)
JP (2) JP7671982B2 (https=)
CN (1) CN112368017A (https=)
AU (1) AU2019262056B2 (https=)
CA (1) CA3098572A1 (https=)
IL (1) IL278294B2 (https=)
WO (1) WO2019213305A1 (https=)

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CN113430178B (zh) * 2021-06-21 2022-10-11 武汉大学 一种表达ii型单纯疱疹病毒蛋白的重组流感病毒株及其制备方法与应用
WO2024145863A1 (en) * 2023-01-05 2024-07-11 Virogin Biotech (Shanghai) Ltd. A NOVEL mRNA VACCINE FOR THE TREATMENT AND PREVENTION OF HPV-ASSOCIATED LESIONS AND TUMORS
CN116497049B (zh) * 2023-05-04 2024-03-22 江苏三仪生物工程有限公司 一种表达犬疱疹病毒gD糖基化蛋白的重组菌及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007511216A (ja) 2003-11-17 2007-05-10 クルセイド ラボラトリーズ リミテッド 変異ウイルス
JP2007511215A (ja) 2003-11-17 2007-05-10 クルセイド ラボラトリーズ リミテッド ウイルス変異株
JP2017510262A (ja) 2014-03-03 2017-04-13 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2375113B (en) * 2000-01-21 2004-10-20 Biovex Ltd A modified, oncolytic, non-laboratory HSV strain and its use in treating cancer
CA2587084C (en) * 2004-10-08 2019-07-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Modulation of replicative fitness by using less frequently used synonym ous codons
WO2008027394A2 (en) * 2006-08-28 2008-03-06 The Wistar Institute Of Anatomy And Biology Constructs for enhancing immune responses
TR201802741T4 (tr) * 2010-05-14 2018-03-21 Univ Oregon Health & Science Rekombinant hcmv ve rhcmv vektörleri ve bunların kullanımları.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007511216A (ja) 2003-11-17 2007-05-10 クルセイド ラボラトリーズ リミテッド 変異ウイルス
JP2007511215A (ja) 2003-11-17 2007-05-10 クルセイド ラボラトリーズ リミテッド ウイルス変異株
JP2017510262A (ja) 2014-03-03 2017-04-13 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BMC Biotechnology，2007年，Vol.7，Article No.22
Expert Review of Vaccines，2012年，Vol.11, No.2，p.189-209
The Journal of Immunology，2017年，Vol.198, Supplement，147.9

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IL278294B1 (en) 2024-09-01
US12150986B2 (en) 2024-11-26
JP2025032104A (ja) 2025-03-11
AU2019262056A1 (en) 2020-10-29
US20230293674A1 (en) 2023-09-21
IL278294A (en) 2020-12-31
AU2019262056B2 (en) 2025-10-02
EP3787680A4 (en) 2022-06-22
CA3098572A1 (en) 2019-11-07
IL278294B2 (en) 2025-01-01
WO2019213305A1 (en) 2019-11-07
US20210236625A1 (en) 2021-08-05
EP3787680A1 (en) 2021-03-10
JP2021522854A (ja) 2021-09-02
CN112368017A (zh) 2021-02-12

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