JP7651094B2 - ペプチド化合物の製造方法 - Google Patents

ペプチド化合物の製造方法 Download PDF

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JP7651094B2
JP7651094B2 JP2023574074A JP2023574074A JP7651094B2 JP 7651094 B2 JP7651094 B2 JP 7651094B2 JP 2023574074 A JP2023574074 A JP 2023574074A JP 2023574074 A JP2023574074 A JP 2023574074A JP 7651094 B2 JP7651094 B2 JP 7651094B2
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group
formula
substituents
compound
hydrocarbon group
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JPWO2023136301A5 (https=
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尚 山本
倫弘 服部
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Chubu University
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Chubu University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2023574074A 2022-01-17 2023-01-12 ペプチド化合物の製造方法 Active JP7651094B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022005195 2022-01-17
JP2022005195 2022-01-17
PCT/JP2023/000653 WO2023136301A1 (ja) 2022-01-17 2023-01-12 ペプチド化合物の製造方法

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JPWO2023136301A1 JPWO2023136301A1 (https=) 2023-07-20
JPWO2023136301A5 JPWO2023136301A5 (https=) 2024-09-12
JP7651094B2 true JP7651094B2 (ja) 2025-03-26

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JP2023574074A Active JP7651094B2 (ja) 2022-01-17 2023-01-12 ペプチド化合物の製造方法

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US (1) US20250092088A1 (https=)
EP (1) EP4446332A4 (https=)
JP (1) JP7651094B2 (https=)
WO (1) WO2023136301A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007078791A (ja) 2005-09-12 2007-03-29 Konica Minolta Holdings Inc 液晶表示素子及び液晶表示素子の製造方法
WO2019069978A1 (ja) 2017-10-03 2019-04-11 日産化学株式会社 ペプチド化合物の製造方法
WO2019198833A1 (ja) 2018-04-13 2019-10-17 Jitsubo株式会社 ペプチド合成方法
WO2020162393A1 (ja) 2019-02-04 2020-08-13 日産化学株式会社 ペプチド化合物の製造方法
WO2021039901A1 (ja) 2019-08-30 2021-03-04 日産化学株式会社 ペプチド化合物の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6744669B2 (ja) 2016-05-23 2020-08-19 学校法人中部大学 水酸基を配向基とするエステルからアミドへの変換触媒
JPWO2018199146A1 (ja) 2017-04-25 2020-02-27 学校法人中部大学 オキシム・ヒドロキシアミンを基質とするエステルからアミドへの変換触媒
CN110662736A (zh) 2017-04-25 2020-01-07 学校法人中部大学 酰胺化合物的制造方法
CN112020492B (zh) 2018-04-25 2023-05-05 学校法人中部大学 酰胺化合物的制造方法
WO2020218497A1 (ja) * 2019-04-25 2020-10-29 味の素株式会社 ペプチドの連続的製造方法
JP7244134B2 (ja) 2019-10-30 2023-03-22 学校法人中部大学 アミド反応用反応剤及びそれを用いたアミド化合物の製造方法
EP4053101A4 (en) 2019-10-30 2024-02-21 Chubu University Educational Foundation REACTANT FOR AMIDE REACTION AND METHOD FOR PRODUCING AN AMIDE COMPOUND USING THE SAME
US20230121469A1 (en) 2020-01-22 2023-04-20 Chubu University Educational Foundation Catalyst for manufacturing amide compound, and method for manufacturing amide compound
JP7063409B1 (ja) * 2021-07-02 2022-05-09 ペプチスター株式会社 Ｆｍоｃ基を除去する方法
JP7063408B1 (ja) * 2021-07-02 2022-05-09 ペプチスター株式会社 液相ペプチド製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007078791A (ja) 2005-09-12 2007-03-29 Konica Minolta Holdings Inc 液晶表示素子及び液晶表示素子の製造方法
WO2019069978A1 (ja) 2017-10-03 2019-04-11 日産化学株式会社 ペプチド化合物の製造方法
WO2019198833A1 (ja) 2018-04-13 2019-10-17 Jitsubo株式会社 ペプチド合成方法
WO2020162393A1 (ja) 2019-02-04 2020-08-13 日産化学株式会社 ペプチド化合物の製造方法
WO2021039901A1 (ja) 2019-08-30 2021-03-04 日産化学株式会社 ペプチド化合物の製造方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J. Org. Chem.，2006年，Vol.71, No.8，p.3299-3302
Journal of Organometallic Chemistry，2006年，Vol.691, No.26，p.5809-5824
Synlett，2000年，No.12，p.1753-1756
Synlett，2000年，No.3，p.400-402
ペプチド合成の新機軸，有機合成化学協会誌，2021年，Vol.79, No.5，p.382-390

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WO2023136301A1 (ja) 2023-07-20
EP4446332A1 (en) 2024-10-16
US20250092088A1 (en) 2025-03-20
EP4446332A4 (en) 2025-04-16
JPWO2023136301A1 (https=) 2023-07-20

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