JP7648026B2 - β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物を含む組成物、並びにその品質評価方法および酵素反応性の判定方法 - Google Patents

β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物を含む組成物、並びにその品質評価方法および酵素反応性の判定方法 Download PDF

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JP7648026B2
JP7648026B2 JP2022509376A JP2022509376A JP7648026B2 JP 7648026 B2 JP7648026 B2 JP 7648026B2 JP 2022509376 A JP2022509376 A JP 2022509376A JP 2022509376 A JP2022509376 A JP 2022509376A JP 7648026 B2 JP7648026 B2 JP 7648026B2
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nmn
reactivity
compound
lactate dehydrogenase
composition
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JPWO2021192683A1 (https=
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由葵子 竹谷
寛和 松川
美子 砂原
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Oriental Yeast Co Ltd
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Oriental Yeast Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022509376A 2020-03-27 2021-02-10 β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物を含む組成物、並びにその品質評価方法および酵素反応性の判定方法 Active JP7648026B2 (ja)

Applications Claiming Priority (3)

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JP2020058429 2020-03-27
JP2020058429 2020-03-27
PCT/JP2021/004912 WO2021192683A1 (ja) 2020-03-27 2021-02-10 β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物、並びにその品質評価方法および酵素反応性の判定方法

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JPWO2021192683A1 JPWO2021192683A1 (https=) 2021-09-30
JP7648026B2 true JP7648026B2 (ja) 2025-03-18

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JP (1) JP7648026B2 (https=)
CN (1) CN115427422A (https=)
WO (1) WO2021192683A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4471153A4 (en) * 2022-01-28 2026-02-18 Oriental Yeast Co Ltd METHOD AND COMPOSITION FOR STABILIZING NICOTINAMIDE ADENINE DINUCLEOTIDE

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017504616A (ja) 2015-03-16 2017-02-09 邦泰生物工程（深▲セン▼）有限公司 β−ニコチンアミドモノヌクレオチドの精製方法
WO2018047715A1 (ja) 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法
JP2018534265A (ja) 2015-10-02 2018-11-22 メトロ インターナショナル バイオテック，エルエルシー β−ニコチンアミドモノヌクレオチドの結晶形態
JP2019525760A (ja) 2016-07-30 2019-09-12 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドホスホリボシルトランスフェラーゼ突然変異体及びその応用

Family Cites Families (5)

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CN101601679B (zh) * 2009-03-17 2011-08-10 中国人民解放军第二军医大学 一种烟酰胺单核苷酸的应用
CN106659729A (zh) * 2015-12-11 2017-05-10 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的药物中的应用及其药物
WO2018023205A1 (zh) * 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种烟酰胺单核苷酸的纯化方法
CN106755209B (zh) * 2016-12-29 2021-07-23 苏州汉酶生物技术有限公司 一种酶法制备β-烟酰胺单核苷酸的方法
US11634690B2 (en) * 2017-01-31 2023-04-25 Oriental Yeast Co., Ltd. Agent for accelerating growth of pluripotent stem cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017504616A (ja) 2015-03-16 2017-02-09 邦泰生物工程（深▲セン▼）有限公司 β−ニコチンアミドモノヌクレオチドの精製方法
JP2018534265A (ja) 2015-10-02 2018-11-22 メトロ インターナショナル バイオテック，エルエルシー β−ニコチンアミドモノヌクレオチドの結晶形態
JP2019525760A (ja) 2016-07-30 2019-09-12 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドホスホリボシルトランスフェラーゼ突然変異体及びその応用
WO2018047715A1 (ja) 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MCPHERSON Alexander Jr.，Interaction of lactate dehydrogenase with its coenzyme, Nicotinamide-adenine dinucleotide，Journal of Molecular Biology，1970年，Vol.51(1)，p.39-46

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JPWO2021192683A1 (https=) 2021-09-30
WO2021192683A1 (ja) 2021-09-30
US20230348520A1 (en) 2023-11-02

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