CN115427422A - 包含β-烟酰胺单核苷酸或其药理学上所容许的盐的化合物、以及其品质评估方法及酶反应性的判定方法 - Google Patents

包含β-烟酰胺单核苷酸或其药理学上所容许的盐的化合物、以及其品质评估方法及酶反应性的判定方法 Download PDF

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CN115427422A
CN115427422A CN202180024394.2A CN202180024394A CN115427422A CN 115427422 A CN115427422 A CN 115427422A CN 202180024394 A CN202180024394 A CN 202180024394A CN 115427422 A CN115427422 A CN 115427422A
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nmn
compound
val
leu
reactivity
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竹谷由葵子
松川宽和
砂原美子
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Oriental Yeast Co Ltd
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Oriental Yeast Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202180024394.2A 2020-03-27 2021-02-10 包含β-烟酰胺单核苷酸或其药理学上所容许的盐的化合物、以及其品质评估方法及酶反应性的判定方法 Pending CN115427422A (zh)

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Application Number Priority Date Filing Date Title
JP2020-058429 2020-03-27
JP2020058429 2020-03-27
PCT/JP2021/004912 WO2021192683A1 (ja) 2020-03-27 2021-02-10 β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物、並びにその品質評価方法および酵素反応性の判定方法

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CN115427422A true CN115427422A (zh) 2022-12-02

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US (1) US20230348520A1 (https=)
JP (1) JP7648026B2 (https=)
CN (1) CN115427422A (https=)
WO (1) WO2021192683A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4471153A4 (en) * 2022-01-28 2026-02-18 Oriental Yeast Co Ltd METHOD AND COMPOSITION FOR STABILIZING NICOTINAMIDE ADENINE DINUCLEOTIDE

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101601679A (zh) * 2009-03-17 2009-12-16 中国人民解放军第二军医大学 一种烟酰胺单核苷酸的应用
CN106755209A (zh) * 2016-12-29 2017-05-31 苏州汉酶生物技术有限公司 一种酶法制备β‑烟酰胺单核苷酸的方法
US20170165282A1 (en) * 2015-12-11 2017-06-15 Bontac Bio-Engineering (Shenzhen) Co., Ltd. Use of beta-nicotinamide mononucleotide in preparation of drugs for preventing and treating arteriosclerosis and cardio-cerebrovascular diseases, and drugs containing the same
WO2018023205A1 (zh) * 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种烟酰胺单核苷酸的纯化方法
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法
CN108697722A (zh) * 2015-10-02 2018-10-23 麦德龙国际生物科技有限责任公司 β-烟酰胺单核苷酸的晶体形式
CN110446780A (zh) * 2017-01-31 2019-11-12 东方酵母工业株式会社 多能干细胞增殖促进剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104817604B (zh) * 2015-03-16 2017-08-04 邦泰生物工程(深圳)有限公司 一种β‑烟酰胺单核苷酸的纯化方法
JP6712356B2 (ja) * 2016-07-30 2020-06-17 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドホスホリボシルトランスフェラーゼ突然変異体及びその応用

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101601679A (zh) * 2009-03-17 2009-12-16 中国人民解放军第二军医大学 一种烟酰胺单核苷酸的应用
CN108697722A (zh) * 2015-10-02 2018-10-23 麦德龙国际生物科技有限责任公司 β-烟酰胺单核苷酸的晶体形式
US20170165282A1 (en) * 2015-12-11 2017-06-15 Bontac Bio-Engineering (Shenzhen) Co., Ltd. Use of beta-nicotinamide mononucleotide in preparation of drugs for preventing and treating arteriosclerosis and cardio-cerebrovascular diseases, and drugs containing the same
WO2018023205A1 (zh) * 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种烟酰胺单核苷酸的纯化方法
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法
CN106755209A (zh) * 2016-12-29 2017-05-31 苏州汉酶生物技术有限公司 一种酶法制备β‑烟酰胺单核苷酸的方法
CN110446780A (zh) * 2017-01-31 2019-11-12 东方酵母工业株式会社 多能干细胞增殖促进剂

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JP7648026B2 (ja) 2025-03-18
WO2021192683A1 (ja) 2021-09-30
US20230348520A1 (en) 2023-11-02

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