JP7646632B2 - 甲状腺ホルモン受容体ベータアゴニスト化合物 - Google Patents
甲状腺ホルモン受容体ベータアゴニスト化合物 Download PDFInfo
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- JP7646632B2 JP7646632B2 JP2022512349A JP2022512349A JP7646632B2 JP 7646632 B2 JP7646632 B2 JP 7646632B2 JP 2022512349 A JP2022512349 A JP 2022512349A JP 2022512349 A JP2022512349 A JP 2022512349A JP 7646632 B2 JP7646632 B2 JP 7646632B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025034294A JP2025106242A (ja) | 2019-08-23 | 2025-03-05 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962891078P | 2019-08-23 | 2019-08-23 | |
| US62/891,078 | 2019-08-23 | ||
| US202062967943P | 2020-01-30 | 2020-01-30 | |
| US62/967,943 | 2020-01-30 | ||
| PCT/US2020/047467 WO2021041237A1 (en) | 2019-08-23 | 2020-08-21 | Thyroid hormone receptor beta agonist compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025034294A Division JP2025106242A (ja) | 2019-08-23 | 2025-03-05 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022544714A JP2022544714A (ja) | 2022-10-20 |
| JPWO2021041237A5 JPWO2021041237A5 (enExample) | 2023-08-28 |
| JP7646632B2 true JP7646632B2 (ja) | 2025-03-17 |
Family
ID=74684314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022512349A Active JP7646632B2 (ja) | 2019-08-23 | 2020-08-21 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
| JP2025034294A Pending JP2025106242A (ja) | 2019-08-23 | 2025-03-05 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025034294A Pending JP2025106242A (ja) | 2019-08-23 | 2025-03-05 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220281849A1 (enExample) |
| EP (1) | EP4017875A4 (enExample) |
| JP (2) | JP7646632B2 (enExample) |
| CN (1) | CN114430743A (enExample) |
| AU (1) | AU2020336272A1 (enExample) |
| CA (1) | CA3154488A1 (enExample) |
| WO (1) | WO2021041237A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| FI3965884T3 (fi) | 2019-05-08 | 2025-04-02 | Aligos Therapeutics Inc | Thr-beetan modulaattoreita, joissa on diokso-1,2,4-triatsyylipääryhmä |
| US12398127B2 (en) | 2019-09-12 | 2025-08-26 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2022011120A1 (en) * | 2020-07-10 | 2022-01-13 | Aligos Therapeutics, Inc. | MODULATORS OF THR-β AND METHODS OF USE THEREOF |
| WO2022037617A1 (zh) * | 2020-08-19 | 2022-02-24 | 成都凡诺西生物医药科技有限公司 | 腈代三嗪类衍生物及其制备方法和应用 |
| EP4301357A4 (en) * | 2021-03-03 | 2025-01-22 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| CN117624073A (zh) * | 2021-03-19 | 2024-03-01 | 南京明德新药研发有限公司 | 双环苯酚类化合物及其应用 |
| WO2022242743A1 (zh) * | 2021-05-21 | 2022-11-24 | 深圳微芯生物科技股份有限公司 | 一种杂环化合物及其应用 |
| CN113979963B (zh) * | 2021-12-24 | 2022-03-11 | 凯思凯旭(上海)医药科技有限公司 | 一种作为甲状腺激素β受体激动剂的化合物及其用途 |
| CN116354934A (zh) * | 2021-12-28 | 2023-06-30 | 中国科学院上海药物研究所 | 一类喹啉类化合物及其制备方法、药物组合物和用途 |
| EP4568664A1 (en) | 2023-04-07 | 2025-06-18 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
| CN120923503A (zh) * | 2025-10-10 | 2025-11-11 | 吉斯凯(苏州)制药有限公司 | 具有杂环结构的化合物、THRβ受体激动剂及用途 |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001114768A (ja) | 1999-09-30 | 2001-04-24 | Pfizer Prod Inc | 甲状腺受容体リガンドとしての６−アザウラシル誘導体 |
| JP2004501132A (ja) | 2000-06-21 | 2004-01-15 | カロ バイオ アクチェブラーグ | 甲状腺受容体リガンド、それらを含む薬学的組成物、および甲状腺ホルモンにより影響を及ぼされる障害の治療におけるそれらの使用 |
| WO2007128492A1 (en) | 2006-05-03 | 2007-11-15 | Karo Bio Ab | Novel pharmaceutical compositions |
| WO2007134864A1 (en) | 2006-05-24 | 2007-11-29 | Karo Bio Ab | Indole derivatives and their use as thyroid receptor ligands |
| JP2009500305A (ja) | 2005-07-04 | 2009-01-08 | カロ バイオ アクチェブラーグ | 甲状腺受容体用アゴニストとしての複素環式化合物 |
| JP2009501759A (ja) | 2005-07-21 | 2009-01-22 | エフ．ホフマン−ラ ロシュ アーゲー | 甲状腺ホルモン受容体アゴニストとしてのピリダジノン誘導体 |
| WO2010122980A1 (ja) | 2009-04-20 | 2010-10-28 | 田辺三菱製薬株式会社 | 新規甲状腺ホルモンβ受容体作動薬 |
| JP2010539209A (ja) | 2007-09-20 | 2010-12-16 | エフ．ホフマン−ラ ロシュ アーゲー | 甲状腺ホルモンアナログのプロドラッグ |
| WO2018075650A1 (en) | 2016-10-18 | 2018-04-26 | Madrigal Pharmaceuticals, Inc. | Methods of treating liver disorders or lipid disorders with a thr-beta agonist |
| WO2019144835A1 (zh) | 2018-01-23 | 2019-08-01 | 深圳市塔吉瑞生物医药有限公司 | 取代的哒嗪酮化合物 |
| JP2022504706A (ja) | 2018-10-12 | 2022-01-13 | インベンティスバイオ カンパニー リミテッド | 甲状腺ホルモン受容体作動薬 |
| JP2022521341A (ja) | 2019-02-21 | 2022-04-06 | ナンジン・ルイジェ・ファーマ・カンパニー・リミテッド | 新規化合物及び甲状腺ホルモン受容体アゴニストとしてのそれらの使用 |
| JP2022532706A (ja) | 2019-05-08 | 2022-07-19 | アリゴス セラピューティクス，インコーポレーテッド | ＴＨＲ－βの調節物質およびその使用方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787652B1 (en) * | 1999-09-30 | 2004-09-07 | Pfizer, Inc. | 6-Azauracil derivatives as thyroid receptor ligands |
-
2020
- 2020-08-21 WO PCT/US2020/047467 patent/WO2021041237A1/en not_active Ceased
- 2020-08-21 CN CN202080066442.XA patent/CN114430743A/zh active Pending
- 2020-08-21 EP EP20856291.8A patent/EP4017875A4/en active Pending
- 2020-08-21 CA CA3154488A patent/CA3154488A1/en active Pending
- 2020-08-21 JP JP2022512349A patent/JP7646632B2/ja active Active
- 2020-08-21 US US17/637,426 patent/US20220281849A1/en active Pending
- 2020-08-21 AU AU2020336272A patent/AU2020336272A1/en active Pending
-
2025
- 2025-03-05 JP JP2025034294A patent/JP2025106242A/ja active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001114768A (ja) | 1999-09-30 | 2001-04-24 | Pfizer Prod Inc | 甲状腺受容体リガンドとしての６−アザウラシル誘導体 |
| JP2004501132A (ja) | 2000-06-21 | 2004-01-15 | カロ バイオ アクチェブラーグ | 甲状腺受容体リガンド、それらを含む薬学的組成物、および甲状腺ホルモンにより影響を及ぼされる障害の治療におけるそれらの使用 |
| JP2009500305A (ja) | 2005-07-04 | 2009-01-08 | カロ バイオ アクチェブラーグ | 甲状腺受容体用アゴニストとしての複素環式化合物 |
| JP2009501759A (ja) | 2005-07-21 | 2009-01-22 | エフ．ホフマン−ラ ロシュ アーゲー | 甲状腺ホルモン受容体アゴニストとしてのピリダジノン誘導体 |
| WO2007128492A1 (en) | 2006-05-03 | 2007-11-15 | Karo Bio Ab | Novel pharmaceutical compositions |
| WO2007134864A1 (en) | 2006-05-24 | 2007-11-29 | Karo Bio Ab | Indole derivatives and their use as thyroid receptor ligands |
| JP2010539209A (ja) | 2007-09-20 | 2010-12-16 | エフ．ホフマン−ラ ロシュ アーゲー | 甲状腺ホルモンアナログのプロドラッグ |
| WO2010122980A1 (ja) | 2009-04-20 | 2010-10-28 | 田辺三菱製薬株式会社 | 新規甲状腺ホルモンβ受容体作動薬 |
| WO2018075650A1 (en) | 2016-10-18 | 2018-04-26 | Madrigal Pharmaceuticals, Inc. | Methods of treating liver disorders or lipid disorders with a thr-beta agonist |
| WO2019144835A1 (zh) | 2018-01-23 | 2019-08-01 | 深圳市塔吉瑞生物医药有限公司 | 取代的哒嗪酮化合物 |
| JP2022504706A (ja) | 2018-10-12 | 2022-01-13 | インベンティスバイオ カンパニー リミテッド | 甲状腺ホルモン受容体作動薬 |
| JP2022521341A (ja) | 2019-02-21 | 2022-04-06 | ナンジン・ルイジェ・ファーマ・カンパニー・リミテッド | 新規化合物及び甲状腺ホルモン受容体アゴニストとしてのそれらの使用 |
| JP2022532706A (ja) | 2019-05-08 | 2022-07-19 | アリゴス セラピューティクス，インコーポレーテッド | ＴＨＲ－βの調節物質およびその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022544714A (ja) | 2022-10-20 |
| WO2021041237A1 (en) | 2021-03-04 |
| CA3154488A1 (en) | 2021-03-04 |
| US20220281849A1 (en) | 2022-09-08 |
| EP4017875A4 (en) | 2023-05-03 |
| JP2025106242A (ja) | 2025-07-15 |
| CN114430743A (zh) | 2022-05-03 |
| AU2020336272A1 (en) | 2022-04-14 |
| EP4017875A1 (en) | 2022-06-29 |
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