AU2020336272A1 - Thyroid hormone receptor beta agonist compounds - Google Patents
Thyroid hormone receptor beta agonist compounds Download PDFInfo
- Publication number
- AU2020336272A1 AU2020336272A1 AU2020336272A AU2020336272A AU2020336272A1 AU 2020336272 A1 AU2020336272 A1 AU 2020336272A1 AU 2020336272 A AU2020336272 A AU 2020336272A AU 2020336272 A AU2020336272 A AU 2020336272A AU 2020336272 A1 AU2020336272 A1 AU 2020336272A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- mixture
- umol
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962891078P | 2019-08-23 | 2019-08-23 | |
| US62/891,078 | 2019-08-23 | ||
| US202062967943P | 2020-01-30 | 2020-01-30 | |
| US62/967,943 | 2020-01-30 | ||
| PCT/US2020/047467 WO2021041237A1 (en) | 2019-08-23 | 2020-08-21 | Thyroid hormone receptor beta agonist compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2020336272A1 true AU2020336272A1 (en) | 2022-04-14 |
Family
ID=74684314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020336272A Pending AU2020336272A1 (en) | 2019-08-23 | 2020-08-21 | Thyroid hormone receptor beta agonist compounds |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220281849A1 (enExample) |
| EP (1) | EP4017875A4 (enExample) |
| JP (2) | JP7646632B2 (enExample) |
| CN (1) | CN114430743A (enExample) |
| AU (1) | AU2020336272A1 (enExample) |
| CA (1) | CA3154488A1 (enExample) |
| WO (1) | WO2021041237A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| KR20220017917A (ko) | 2019-05-08 | 2022-02-14 | 알리고스 테라퓨틱스 인코포레이티드 | Thr-베타의 조절제 및 이의 사용 방법 |
| WO2021050945A1 (en) | 2019-09-12 | 2021-03-18 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| AU2021306314A1 (en) * | 2020-07-10 | 2023-02-09 | Aligos Therapeutics, Inc. | Modulators of THR-β and methods of use thereof |
| CN114075173A (zh) * | 2020-08-19 | 2022-02-22 | 成都凡诺西生物医药科技有限公司 | 腈代三嗪类衍生物及其制备方法和应用 |
| US20240059682A1 (en) * | 2021-03-03 | 2024-02-22 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2022194278A1 (zh) * | 2021-03-19 | 2022-09-22 | 南京明德新药研发有限公司 | 双环苯酚类化合物及其应用 |
| WO2022242743A1 (zh) * | 2021-05-21 | 2022-11-24 | 深圳微芯生物科技股份有限公司 | 一种杂环化合物及其应用 |
| CN113979963B (zh) * | 2021-12-24 | 2022-03-11 | 凯思凯旭(上海)医药科技有限公司 | 一种作为甲状腺激素β受体激动剂的化合物及其用途 |
| CN116354934A (zh) * | 2021-12-28 | 2023-06-30 | 中国科学院上海药物研究所 | 一类喹啉类化合物及其制备方法、药物组合物和用途 |
| EP4568664A1 (en) | 2023-04-07 | 2025-06-18 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
| CN120923503A (zh) * | 2025-10-10 | 2025-11-11 | 吉斯凯(苏州)制药有限公司 | 具有杂环结构的化合物、THRβ受体激动剂及用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2240017T3 (es) | 1999-09-30 | 2005-10-16 | Pfizer Products Inc. | Derivados de 6-azauracilo como ligandos de receptores tiroideos. |
| US6787652B1 (en) * | 1999-09-30 | 2004-09-07 | Pfizer, Inc. | 6-Azauracil derivatives as thyroid receptor ligands |
| GB0015205D0 (en) | 2000-06-21 | 2000-08-09 | Karobio Ab | Bioisosteric thyroid receptor ligands and method |
| GB0513692D0 (en) * | 2005-07-04 | 2005-08-10 | Karobio Ab | Novel pharmaceutical compositions |
| JP5000649B2 (ja) * | 2005-07-21 | 2012-08-15 | エフ．ホフマン−ラ ロシュ アーゲー | 甲状腺ホルモン受容体アゴニストとしてのピリダジノン誘導体 |
| GB0608724D0 (en) | 2006-05-03 | 2006-06-14 | Karobio Ab | Novel Pharmaceutical Compositions |
| GB0610322D0 (en) | 2006-05-24 | 2006-07-05 | Karobio Ab | Novel pharmaceutical compositions |
| US8076334B2 (en) * | 2007-09-20 | 2011-12-13 | Hoffmann-La Roche Inc. | Prodrugs of thyroid hormone analogs |
| JP5487202B2 (ja) * | 2009-04-20 | 2014-05-07 | 田辺三菱製薬株式会社 | 新規甲状腺ホルモンβ受容体作動薬 |
| KR20190109387A (ko) | 2016-10-18 | 2019-09-25 | 마드리갈 파마슈티칼스, 인크. | Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법 |
| US11485729B2 (en) * | 2018-01-23 | 2022-11-01 | Shenzhen Targetrx, Inc. | Substituted pyridazinone compound |
| KR20210076932A (ko) | 2018-10-12 | 2021-06-24 | 인벤티스바이오 컴퍼니 리미티드 | 갑상선 호르몬 수용체 작용제 |
| CN113474335B (zh) | 2019-02-21 | 2024-12-03 | 南京瑞捷医药科技有限公司 | 化合物及其作为甲状腺激素受体激动剂的用途 |
| KR20220017917A (ko) | 2019-05-08 | 2022-02-14 | 알리고스 테라퓨틱스 인코포레이티드 | Thr-베타의 조절제 및 이의 사용 방법 |
-
2020
- 2020-08-21 CA CA3154488A patent/CA3154488A1/en active Pending
- 2020-08-21 EP EP20856291.8A patent/EP4017875A4/en active Pending
- 2020-08-21 CN CN202080066442.XA patent/CN114430743A/zh active Pending
- 2020-08-21 US US17/637,426 patent/US20220281849A1/en active Pending
- 2020-08-21 WO PCT/US2020/047467 patent/WO2021041237A1/en not_active Ceased
- 2020-08-21 JP JP2022512349A patent/JP7646632B2/ja active Active
- 2020-08-21 AU AU2020336272A patent/AU2020336272A1/en active Pending
-
2025
- 2025-03-05 JP JP2025034294A patent/JP2025106242A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4017875A1 (en) | 2022-06-29 |
| CN114430743A (zh) | 2022-05-03 |
| JP2025106242A (ja) | 2025-07-15 |
| WO2021041237A1 (en) | 2021-03-04 |
| JP7646632B2 (ja) | 2025-03-17 |
| EP4017875A4 (en) | 2023-05-03 |
| CA3154488A1 (en) | 2021-03-04 |
| US20220281849A1 (en) | 2022-09-08 |
| JP2022544714A (ja) | 2022-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HB | Alteration of name in register |
Owner name: TERNS PHARMACEUTICALS, INC. Free format text: FORMER NAME(S): TERNS, INC. |