JP7646213B2 - がんの処置に用いるny-eso-1含有人工アジュバントベクター細胞 - Google Patents

がんの処置に用いるny-eso-1含有人工アジュバントベクター細胞 Download PDF

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JP7646213B2
JP7646213B2 JP2021562641A JP2021562641A JP7646213B2 JP 7646213 B2 JP7646213 B2 JP 7646213B2 JP 2021562641 A JP2021562641 A JP 2021562641A JP 2021562641 A JP2021562641 A JP 2021562641A JP 7646213 B2 JP7646213 B2 JP 7646213B2
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cells
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彩佳 秋葉
達也 奥平
泰英 増原
恵介 大隅
眞一郎 藤井
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RIKEN
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JP2021562641A 2019-12-02 2020-12-01 がんの処置に用いるny-eso-1含有人工アジュバントベクター細胞 Active JP7646213B2 (ja)

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JP2019217704 2019-12-02
JP2019217704 2019-12-02
PCT/JP2020/044586 WO2021112055A1 (ja) 2019-12-02 2020-12-01 がんの処置に用いるny-eso-1含有人工アジュバントベクター細胞

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JPWO2021112055A5 JPWO2021112055A5 (https=) 2023-10-30
JP7646213B2 true JP7646213B2 (ja) 2025-03-17

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EP (1) EP4071240A4 (https=)
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KR (1) KR20220119030A (https=)
CN (1) CN114787344A (https=)
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AU (1) AU2020394993A1 (https=)
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US20130189302A1 (en) * 2006-02-22 2013-07-25 Riken Immunotherapeutic method using artificial adjuvant vector cells that co-express cd1d and target antigen
WO2025230010A1 (ja) * 2024-05-02 2025-11-06 国立研究開発法人理化学研究所 CD1d導入前にCD1dリガンドでインキュベートされた細胞

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007097370A1 (ja) 2006-02-22 2007-08-30 Riken CD1dリガンドをパルスした、標的抗原及びCD1dの共発現細胞による免疫療法
WO2010061930A1 (ja) 2008-11-28 2010-06-03 独立行政法人理化学研究所 CD1d及び標的抗原の共発現アロ細胞を用いた免疫療法
JP2018521674A (ja) 2015-07-31 2018-08-09 シンロジック オペレーティング カンパニー インコーポレイテッド プロピオネート異化を伴う障害を治療するために操作された細菌

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130189302A1 (en) * 2006-02-22 2013-07-25 Riken Immunotherapeutic method using artificial adjuvant vector cells that co-express cd1d and target antigen
JP2007261876A (ja) 2006-03-28 2007-10-11 Tdk Corp 誘電体粒子、誘電体磁器組成物およびその製造方法
WO2008057795A2 (en) * 2006-10-27 2008-05-15 Temple University - Of The Commonwealth System Of Higher Education Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera
AU2008219020B2 (en) * 2007-02-21 2013-08-22 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CDId molecules
KR101194265B1 (ko) 2008-12-01 2012-10-29 주식회사 한국인삼공사 해양심층수를 이용하여 인삼 또는 홍삼 농축액의 고미 제거방법
BR112012024375A2 (pt) 2010-03-25 2016-05-24 3M Innovative Properties Co camada compósita
EP2738253A4 (en) 2011-07-29 2015-04-22 Riken CELL FOR USE IN IMMUNOTHERAPY WITH A MODIFIED NUCLEIC ACIDIC CONSTRUCTIVE FOR WILMS TUMORGEN PRODUCT OR FRAGMENT THEREOF, METHOD FOR PRODUCING THIS CELL AND NUCLEIC ACIDIC CONCRETE SAID
US10316332B2 (en) * 2011-07-29 2019-06-11 Riken Cell for immunotherapy, including modified nucleic acid construct encoding Wilms tumor gene product
CN108064176A (zh) * 2015-04-22 2018-05-22 库瑞瓦格股份公司 用于治疗肿瘤疾病的含有rna的组合物
US20170216370A1 (en) 2015-07-31 2017-08-03 Synlogic, Inc. Bacteria engineered to treat disorders involving propionate catabolism
JP2020514370A (ja) * 2017-03-17 2020-05-21 キュアバック アーゲー 組合せ抗癌療法のためのrnaワクチン及び免疫チェックポイント阻害剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007097370A1 (ja) 2006-02-22 2007-08-30 Riken CD1dリガンドをパルスした、標的抗原及びCD1dの共発現細胞による免疫療法
WO2010061930A1 (ja) 2008-11-28 2010-06-03 独立行政法人理化学研究所 CD1d及び標的抗原の共発現アロ細胞を用いた免疫療法
JP2018521674A (ja) 2015-07-31 2018-08-09 シンロジック オペレーティング カンパニー インコーポレイテッド プロピオネート異化を伴う障害を治療するために操作された細菌

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAHIPAL, A et al.,Cancer Immunology, Immunotherapy,2019年05月08日,Vol.68,p.1211-1222
白畑實隆 他,SB-2p-3 汎用高発現動物宿主細胞・ベクター系の開発,日本農芸化学会大会講演要旨集,74巻臨時増刊号,社団法人 日本農芸化学会,2000年,p.469

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JOP20220121A1 (ar) 2022-05-23
CL2022001459A1 (es) 2023-02-24
MX2022006716A (es) 2022-09-12
EP4071240A4 (en) 2024-01-17
KR20220119030A (ko) 2022-08-26
DOP2022000108A (es) 2022-10-31
US20230330200A1 (en) 2023-10-19
WO2021112055A1 (ja) 2021-06-10
AR120648A1 (es) 2022-03-09
CA3162277A1 (en) 2021-06-10
JPWO2021112055A1 (https=) 2021-06-10
EP4071240A1 (en) 2022-10-12
US20230000965A1 (en) 2023-01-05
TW202134431A (zh) 2021-09-16
BR112022010763A2 (pt) 2022-08-23
CN114787344A (zh) 2022-07-22
ECSP22049399A (es) 2022-08-31
PE20221463A1 (es) 2022-09-21
IL293482A (en) 2022-08-01
PH12022551334A1 (en) 2023-11-20
AU2020394993A1 (en) 2022-06-09
CO2022008738A2 (es) 2022-07-19
CR20220320A (es) 2022-11-03

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