JP7614092B2 - ミトコンドリア標的化ペプチド - Google Patents

ミトコンドリア標的化ペプチド Download PDF

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Publication number
JP7614092B2
JP7614092B2 JP2021533219A JP2021533219A JP7614092B2 JP 7614092 B2 JP7614092 B2 JP 7614092B2 JP 2021533219 A JP2021533219 A JP 2021533219A JP 2021533219 A JP2021533219 A JP 2021533219A JP 7614092 B2 JP7614092 B2 JP 7614092B2
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amino
mmol
amino acid
synthesis
ischemia
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Japanese (ja)
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JP2022511939A5 (enExample
JP2022511939A (ja
Inventor
ヂォン，グオヂュー
ジェイ バンバーガー，マーク
スムクステ，イネセ
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Stealth Biotherapeutics Inc
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Stealth Biotherapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021533219A 2018-12-18 2019-11-19 ミトコンドリア標的化ペプチド Active JP7614092B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862781153P 2018-12-18 2018-12-18
US62/781,153 2018-12-18
US201962892939P 2019-08-28 2019-08-28
US62/892,939 2019-08-28
PCT/US2019/062283 WO2020131282A1 (en) 2018-12-18 2019-11-19 Mitochondria-targeting peptides

Publications (3)

Publication Number Publication Date
JP2022511939A JP2022511939A (ja) 2022-02-01
JP2022511939A5 JP2022511939A5 (enExample) 2022-11-21
JP7614092B2 true JP7614092B2 (ja) 2025-01-15

Family

ID=71101606

Family Applications (1)

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JP2021533219A Active JP7614092B2 (ja) 2018-12-18 2019-11-19 ミトコンドリア標的化ペプチド

Country Status (9)

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US (2) US12404300B2 (enExample)
EP (1) EP3898652A4 (enExample)
JP (1) JP7614092B2 (enExample)
KR (1) KR20210093957A (enExample)
CN (1) CN113544138B (enExample)
AU (1) AU2019403856B2 (enExample)
CA (1) CA3123368A1 (enExample)
IL (2) IL284006B2 (enExample)
WO (1) WO2020131282A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
IL284006B2 (en) 2018-12-18 2024-12-01 Stealth Biotherapeutics Corp Mitochondria-targeting peptides
AU2019401254B2 (en) 2018-12-18 2025-05-01 Stealth Biotherapeutics Inc. Analogs that target mitochondrial diseases
CN118955233B (zh) * 2024-07-27 2025-05-06 康龙化成手性医药技术(宁波)有限公司 一种单取代双环[1.1.1]戊烷(bcp)的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516652A (ja) 2003-02-04 2006-07-06 コーネル リサーチ ファウンデイション インコーポレイテッド ミトコンドリア透過性転移の阻止方法
JP2013522311A (ja) 2010-03-15 2013-06-13 ステルス ペプチドズ インターナショナル インコーポレイテッド シクロスポリンおよび芳香族カチオン性ペプチドを用いた併用療法
JP2013531682A (ja) 2010-07-09 2013-08-08 ステルス ペプチドズ インターナショナル インコーポレイテッド 虚血／再灌流障害に続くノーリフローの予防又は処置方法
JP2014518213A (ja) 2011-06-14 2014-07-28 ステルス ペプチドズ インターナショナル インコーポレイテッド 芳香族カチオン性ペプチド及びその使用
WO2017093897A1 (en) 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012022467A2 (en) 2010-08-16 2012-02-23 Santhera Pharmaceuticals (Schweiz) Ag Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function
US8383919B2 (en) 2010-12-14 2013-02-26 Xueyun Gao Highly fluorescent peptide-metallic nanoclusters as bio-probes and methods of synthesis thereof
EP3466439A1 (en) * 2011-12-09 2019-04-10 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
AU2013222237B2 (en) * 2012-02-23 2017-10-05 Cornell University Aromatic-cationic peptides and uses of same
WO2017180535A1 (en) * 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides
IL284006B2 (en) 2018-12-18 2024-12-01 Stealth Biotherapeutics Corp Mitochondria-targeting peptides
AU2019401254B2 (en) 2018-12-18 2025-05-01 Stealth Biotherapeutics Inc. Analogs that target mitochondrial diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516652A (ja) 2003-02-04 2006-07-06 コーネル リサーチ ファウンデイション インコーポレイテッド ミトコンドリア透過性転移の阻止方法
JP2013522311A (ja) 2010-03-15 2013-06-13 ステルス ペプチドズ インターナショナル インコーポレイテッド シクロスポリンおよび芳香族カチオン性ペプチドを用いた併用療法
JP2013531682A (ja) 2010-07-09 2013-08-08 ステルス ペプチドズ インターナショナル インコーポレイテッド 虚血／再灌流障害に続くノーリフローの予防又は処置方法
JP2014518213A (ja) 2011-06-14 2014-07-28 ステルス ペプチドズ インターナショナル インコーポレイテッド 芳香族カチオン性ペプチド及びその使用
WO2017093897A1 (en) 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cardiovascular Drugs Therapy，2016年，Vol.30, No.6，pp.559-566

Also Published As

Publication number Publication date
WO2020131282A1 (en) 2020-06-25
CA3123368A1 (en) 2020-06-25
IL314309B1 (en) 2025-05-01
IL284006B1 (en) 2024-08-01
IL284006B2 (en) 2024-12-01
AU2019403856A1 (en) 2021-06-24
US20260055136A1 (en) 2026-02-26
IL314309A (en) 2024-09-01
US20220041653A1 (en) 2022-02-10
EP3898652A1 (en) 2021-10-27
JP2022511939A (ja) 2022-02-01
IL314309B2 (en) 2025-09-01
EP3898652A4 (en) 2022-08-24
IL284006A (en) 2021-08-31
KR20210093957A (ko) 2021-07-28
AU2019403856B2 (en) 2025-05-01
CN113544138A (zh) 2021-10-22
CN113544138B (zh) 2024-10-29
US12404300B2 (en) 2025-09-02

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