IL284006B2 - Mitochondria-targeting peptides - Google Patents
Mitochondria-targeting peptidesInfo
- Publication number
- IL284006B2 IL284006B2 IL284006A IL28400621A IL284006B2 IL 284006 B2 IL284006 B2 IL 284006B2 IL 284006 A IL284006 A IL 284006A IL 28400621 A IL28400621 A IL 28400621A IL 284006 B2 IL284006 B2 IL 284006B2
- Authority
- IL
- Israel
- Prior art keywords
- compound
- amino
- mmol
- group
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862781153P | 2018-12-18 | 2018-12-18 | |
| US201962892939P | 2019-08-28 | 2019-08-28 | |
| PCT/US2019/062283 WO2020131282A1 (en) | 2018-12-18 | 2019-11-19 | Mitochondria-targeting peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL284006A IL284006A (en) | 2021-08-31 |
| IL284006B1 IL284006B1 (en) | 2024-08-01 |
| IL284006B2 true IL284006B2 (en) | 2024-12-01 |
Family
ID=71101606
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL284006A IL284006B2 (en) | 2018-12-18 | 2019-11-19 | Mitochondria-targeting peptides |
| IL314309A IL314309B2 (en) | 2018-12-18 | 2019-11-19 | Mitochondria-targeted peptides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL314309A IL314309B2 (en) | 2018-12-18 | 2019-11-19 | Mitochondria-targeted peptides |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12404300B2 (enExample) |
| EP (1) | EP3898652A4 (enExample) |
| JP (1) | JP7614092B2 (enExample) |
| KR (1) | KR20210093957A (enExample) |
| CN (1) | CN113544138B (enExample) |
| AU (1) | AU2019403856B2 (enExample) |
| CA (1) | CA3123368A1 (enExample) |
| IL (2) | IL284006B2 (enExample) |
| WO (1) | WO2020131282A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11332499B2 (en) | 2018-08-16 | 2022-05-17 | Regents Of The University Of Minnesota | Cyclic peptides and methods of use thereof |
| IL284006B2 (en) | 2018-12-18 | 2024-12-01 | Stealth Biotherapeutics Corp | Mitochondria-targeting peptides |
| AU2019401254B2 (en) | 2018-12-18 | 2025-05-01 | Stealth Biotherapeutics Inc. | Analogs that target mitochondrial diseases |
| CN118955233B (zh) * | 2024-07-27 | 2025-05-06 | 康龙化成手性医药技术(宁波)有限公司 | 一种单取代双环[1.1.1]戊烷(bcp)的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2436011T3 (es) | 2003-02-04 | 2013-12-26 | Cornell Research Foundation, Inc. | Métodos para prevenir la transición de la permeabilidad mitocondrial |
| EP2547352A4 (en) | 2010-03-15 | 2013-10-09 | Stealth Peptides Int Inc | COMBINATION THERAPIES USING CYCLOSPORINE AND AROMATIC CATIONIC PEPTIDES |
| JP6319738B2 (ja) | 2010-07-09 | 2018-05-09 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 虚血／再灌流障害に続くノーリフローの予防又は処置方法 |
| WO2012022467A2 (en) | 2010-08-16 | 2012-02-23 | Santhera Pharmaceuticals (Schweiz) Ag | Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function |
| US8383919B2 (en) | 2010-12-14 | 2013-02-26 | Xueyun Gao | Highly fluorescent peptide-metallic nanoclusters as bio-probes and methods of synthesis thereof |
| CN103764159A (zh) | 2011-06-14 | 2014-04-30 | 康肽德生物医药技术有限公司 | 芳香族阳离子肽及其用途 |
| EP3466439A1 (en) * | 2011-12-09 | 2019-04-10 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| AU2013222237B2 (en) * | 2012-02-23 | 2017-10-05 | Cornell University | Aromatic-cationic peptides and uses of same |
| WO2017093897A1 (en) | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| WO2017180535A1 (en) * | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
| IL284006B2 (en) | 2018-12-18 | 2024-12-01 | Stealth Biotherapeutics Corp | Mitochondria-targeting peptides |
| AU2019401254B2 (en) | 2018-12-18 | 2025-05-01 | Stealth Biotherapeutics Inc. | Analogs that target mitochondrial diseases |
-
2019
- 2019-11-19 IL IL284006A patent/IL284006B2/en unknown
- 2019-11-19 EP EP19898721.6A patent/EP3898652A4/en active Pending
- 2019-11-19 IL IL314309A patent/IL314309B2/en unknown
- 2019-11-19 CN CN201980083951.0A patent/CN113544138B/zh active Active
- 2019-11-19 JP JP2021533219A patent/JP7614092B2/ja active Active
- 2019-11-19 WO PCT/US2019/062283 patent/WO2020131282A1/en not_active Ceased
- 2019-11-19 AU AU2019403856A patent/AU2019403856B2/en active Active
- 2019-11-19 CA CA3123368A patent/CA3123368A1/en active Pending
- 2019-11-19 KR KR1020217018413A patent/KR20210093957A/ko not_active Ceased
- 2019-11-19 US US17/414,103 patent/US12404300B2/en active Active
-
2025
- 2025-06-12 US US19/236,079 patent/US20260055136A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020131282A1 (en) | 2020-06-25 |
| CA3123368A1 (en) | 2020-06-25 |
| JP7614092B2 (ja) | 2025-01-15 |
| IL314309B1 (en) | 2025-05-01 |
| IL284006B1 (en) | 2024-08-01 |
| AU2019403856A1 (en) | 2021-06-24 |
| US20260055136A1 (en) | 2026-02-26 |
| IL314309A (en) | 2024-09-01 |
| US20220041653A1 (en) | 2022-02-10 |
| EP3898652A1 (en) | 2021-10-27 |
| JP2022511939A (ja) | 2022-02-01 |
| IL314309B2 (en) | 2025-09-01 |
| EP3898652A4 (en) | 2022-08-24 |
| IL284006A (en) | 2021-08-31 |
| KR20210093957A (ko) | 2021-07-28 |
| AU2019403856B2 (en) | 2025-05-01 |
| CN113544138A (zh) | 2021-10-22 |
| CN113544138B (zh) | 2024-10-29 |
| US12404300B2 (en) | 2025-09-02 |
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