AU2019403856B2 - Mitochondria-targeting peptides - Google Patents

Mitochondria-targeting peptides Download PDF

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Publication number
AU2019403856B2
AU2019403856B2 AU2019403856A AU2019403856A AU2019403856B2 AU 2019403856 B2 AU2019403856 B2 AU 2019403856B2 AU 2019403856 A AU2019403856 A AU 2019403856A AU 2019403856 A AU2019403856 A AU 2019403856A AU 2019403856 B2 AU2019403856 B2 AU 2019403856B2
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AU
Australia
Prior art keywords
compound
group
amino
mmol
ischemia
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AU2019403856A
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English (en)
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AU2019403856A1 (en
Inventor
Mark J. BAMBERGER
Inese Smukste
Guozhu ZHENG
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Stealth Biotherapeutics Inc
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Stealth Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of AU2019403856A1 publication Critical patent/AU2019403856A1/en
Assigned to STEALTH BIOTHERAPEUTICS INC. reassignment STEALTH BIOTHERAPEUTICS INC. Request for Assignment Assignors: STEALTH BIOTHERAPEUTICS CORP.
Application granted granted Critical
Publication of AU2019403856B2 publication Critical patent/AU2019403856B2/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2019403856A 2018-12-18 2019-11-19 Mitochondria-targeting peptides Active AU2019403856B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862781153P 2018-12-18 2018-12-18
US62/781,153 2018-12-18
US201962892939P 2019-08-28 2019-08-28
US62/892,939 2019-08-28
PCT/US2019/062283 WO2020131282A1 (en) 2018-12-18 2019-11-19 Mitochondria-targeting peptides

Publications (2)

Publication Number Publication Date
AU2019403856A1 AU2019403856A1 (en) 2021-06-24
AU2019403856B2 true AU2019403856B2 (en) 2025-05-01

Family

ID=71101606

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019403856A Active AU2019403856B2 (en) 2018-12-18 2019-11-19 Mitochondria-targeting peptides

Country Status (9)

Country Link
US (2) US12404300B2 (enExample)
EP (1) EP3898652A4 (enExample)
JP (1) JP7614092B2 (enExample)
KR (1) KR20210093957A (enExample)
CN (1) CN113544138B (enExample)
AU (1) AU2019403856B2 (enExample)
CA (1) CA3123368A1 (enExample)
IL (2) IL284006B2 (enExample)
WO (1) WO2020131282A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
IL284006B2 (en) 2018-12-18 2024-12-01 Stealth Biotherapeutics Corp Mitochondria-targeting peptides
AU2019401254B2 (en) 2018-12-18 2025-05-01 Stealth Biotherapeutics Inc. Analogs that target mitochondrial diseases
CN118955233B (zh) * 2024-07-27 2025-05-06 康龙化成手性医药技术(宁波)有限公司 一种单取代双环[1.1.1]戊烷(bcp)的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004070054A2 (en) * 2003-02-04 2004-08-19 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
US20110118441A1 (en) * 2010-12-14 2011-05-19 Xueyun Gao Synthesis of Highly Fluorescent Peptide-Metallic Nanoclusters as Bio-probes
WO2011116007A1 (en) * 2010-03-15 2011-09-22 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
WO2017093897A1 (en) * 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
WO2017180535A1 (en) * 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6319738B2 (ja) 2010-07-09 2018-05-09 ステルス ペプチドズ インターナショナル インコーポレイテッド 虚血／再灌流障害に続くノーリフローの予防又は処置方法
WO2012022467A2 (en) 2010-08-16 2012-02-23 Santhera Pharmaceuticals (Schweiz) Ag Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function
CN103764159A (zh) 2011-06-14 2014-04-30 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
EP3466439A1 (en) * 2011-12-09 2019-04-10 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
AU2013222237B2 (en) * 2012-02-23 2017-10-05 Cornell University Aromatic-cationic peptides and uses of same
IL284006B2 (en) 2018-12-18 2024-12-01 Stealth Biotherapeutics Corp Mitochondria-targeting peptides
AU2019401254B2 (en) 2018-12-18 2025-05-01 Stealth Biotherapeutics Inc. Analogs that target mitochondrial diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004070054A2 (en) * 2003-02-04 2004-08-19 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
WO2011116007A1 (en) * 2010-03-15 2011-09-22 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
US20110118441A1 (en) * 2010-12-14 2011-05-19 Xueyun Gao Synthesis of Highly Fluorescent Peptide-Metallic Nanoclusters as Bio-probes
WO2017093897A1 (en) * 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
WO2017180535A1 (en) * 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LONGXIANG, B., et al., 2014, "[Dmt1]DALDA analogues with enhanced[mu]opioid agonist potency and with a mixed[mu]/[kappa]opioid activity", Biorganic, 22(7), pages 2333-2338 *

Also Published As

Publication number Publication date
WO2020131282A1 (en) 2020-06-25
CA3123368A1 (en) 2020-06-25
JP7614092B2 (ja) 2025-01-15
IL314309B1 (en) 2025-05-01
IL284006B1 (en) 2024-08-01
IL284006B2 (en) 2024-12-01
AU2019403856A1 (en) 2021-06-24
US20260055136A1 (en) 2026-02-26
IL314309A (en) 2024-09-01
US20220041653A1 (en) 2022-02-10
EP3898652A1 (en) 2021-10-27
JP2022511939A (ja) 2022-02-01
IL314309B2 (en) 2025-09-01
EP3898652A4 (en) 2022-08-24
IL284006A (en) 2021-08-31
KR20210093957A (ko) 2021-07-28
CN113544138A (zh) 2021-10-22
CN113544138B (zh) 2024-10-29
US12404300B2 (en) 2025-09-02

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: STEALTH BIOTHERAPEUTICS INC.

Free format text: FORMER APPLICANT(S): STEALTH BIOTHERAPEUTICS CORP.

FGA Letters patent sealed or granted (standard patent)