CN113544138B - 线粒体靶向肽 - Google Patents

线粒体靶向肽 Download PDF

Info

Publication number
CN113544138B
CN113544138B CN201980083951.0A CN201980083951A CN113544138B CN 113544138 B CN113544138 B CN 113544138B CN 201980083951 A CN201980083951 A CN 201980083951A CN 113544138 B CN113544138 B CN 113544138B
Authority
CN
China
Prior art keywords
amino
mmol
ischemia
amino acid
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980083951.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN113544138A (zh
Inventor
G·郑
M·J·巴姆伯格
I·斯穆克斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stealth Biotherapeutics Corp
Original Assignee
Stealth Biotherapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stealth Biotherapeutics Corp filed Critical Stealth Biotherapeutics Corp
Publication of CN113544138A publication Critical patent/CN113544138A/zh
Application granted granted Critical
Publication of CN113544138B publication Critical patent/CN113544138B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980083951.0A 2018-12-18 2019-11-19 线粒体靶向肽 Active CN113544138B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862781153P 2018-12-18 2018-12-18
US62/781153 2018-12-18
US201962892939P 2019-08-28 2019-08-28
US62/892939 2019-08-28
PCT/US2019/062283 WO2020131282A1 (en) 2018-12-18 2019-11-19 Mitochondria-targeting peptides

Publications (2)

Publication Number Publication Date
CN113544138A CN113544138A (zh) 2021-10-22
CN113544138B true CN113544138B (zh) 2024-10-29

Family

ID=71101606

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980083951.0A Active CN113544138B (zh) 2018-12-18 2019-11-19 线粒体靶向肽

Country Status (9)

Country Link
US (2) US12404300B2 (enExample)
EP (1) EP3898652A4 (enExample)
JP (1) JP7614092B2 (enExample)
KR (1) KR20210093957A (enExample)
CN (1) CN113544138B (enExample)
AU (1) AU2019403856B2 (enExample)
CA (1) CA3123368A1 (enExample)
IL (2) IL284006B2 (enExample)
WO (1) WO2020131282A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
IL284006B2 (en) 2018-12-18 2024-12-01 Stealth Biotherapeutics Corp Mitochondria-targeting peptides
AU2019401254B2 (en) 2018-12-18 2025-05-01 Stealth Biotherapeutics Inc. Analogs that target mitochondrial diseases
CN118955233B (zh) * 2024-07-27 2025-05-06 康龙化成手性医药技术(宁波)有限公司 一种单取代双环[1.1.1]戊烷(bcp)的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017180535A1 (en) * 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2436011T3 (es) 2003-02-04 2013-12-26 Cornell Research Foundation, Inc. Métodos para prevenir la transición de la permeabilidad mitocondrial
EP2547352A4 (en) 2010-03-15 2013-10-09 Stealth Peptides Int Inc COMBINATION THERAPIES USING CYCLOSPORINE AND AROMATIC CATIONIC PEPTIDES
JP6319738B2 (ja) 2010-07-09 2018-05-09 ステルス ペプチドズ インターナショナル インコーポレイテッド 虚血／再灌流障害に続くノーリフローの予防又は処置方法
WO2012022467A2 (en) 2010-08-16 2012-02-23 Santhera Pharmaceuticals (Schweiz) Ag Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function
US8383919B2 (en) 2010-12-14 2013-02-26 Xueyun Gao Highly fluorescent peptide-metallic nanoclusters as bio-probes and methods of synthesis thereof
CN103764159A (zh) 2011-06-14 2014-04-30 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
EP3466439A1 (en) * 2011-12-09 2019-04-10 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
AU2013222237B2 (en) * 2012-02-23 2017-10-05 Cornell University Aromatic-cationic peptides and uses of same
WO2017093897A1 (en) 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
IL284006B2 (en) 2018-12-18 2024-12-01 Stealth Biotherapeutics Corp Mitochondria-targeting peptides
AU2019401254B2 (en) 2018-12-18 2025-05-01 Stealth Biotherapeutics Inc. Analogs that target mitochondrial diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017180535A1 (en) * 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides

Also Published As

Publication number Publication date
WO2020131282A1 (en) 2020-06-25
CA3123368A1 (en) 2020-06-25
JP7614092B2 (ja) 2025-01-15
IL314309B1 (en) 2025-05-01
IL284006B1 (en) 2024-08-01
IL284006B2 (en) 2024-12-01
AU2019403856A1 (en) 2021-06-24
US20260055136A1 (en) 2026-02-26
IL314309A (en) 2024-09-01
US20220041653A1 (en) 2022-02-10
EP3898652A1 (en) 2021-10-27
JP2022511939A (ja) 2022-02-01
IL314309B2 (en) 2025-09-01
EP3898652A4 (en) 2022-08-24
IL284006A (en) 2021-08-31
KR20210093957A (ko) 2021-07-28
AU2019403856B2 (en) 2025-05-01
CN113544138A (zh) 2021-10-22
US12404300B2 (en) 2025-09-02

Similar Documents

Publication Publication Date Title
JP7576670B2 (ja) ミトコンドリア標的化ペプチド
US20260055136A1 (en) Mitochondria-targeting peptides
JP7606966B2 (ja) ミトコンドリア病を標的とするアナログ
US20240092832A1 (en) Deuterated tetrapeptides that target mitochondria
AU2020260489A1 (en) Chiral peptides
WO2021262710A1 (en) Prodrugs of mitochodria-targeting oligopeptides
WO2021262708A1 (en) Prodrugs of mitochodria-targeting oligopeptides
HK40039982B (zh) 线粒体靶向肽
HK40116853A (zh) 线粒体靶向肽
HK40107199A (zh) 线粒体靶向肽
HK40039982A (en) Mitochondria-targeting peptides

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20220128

Address after: Massachusetts

Applicant after: STEALTH BIOTHERAPEUTICS

Address before: Monaco city of Monaco

Applicant before: STEALTH BIOTHERAPEUTICS

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant