JP7610515B2 - ヒト化抗Ｎ短縮型アミロイドβモノクローナル抗体 - Google Patents

ヒト化抗Ｎ短縮型アミロイドβモノクローナル抗体 Download PDF

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JP7610515B2
JP7610515B2 JP2021543565A JP2021543565A JP7610515B2 JP 7610515 B2 JP7610515 B2 JP 7610515B2 JP 2021543565 A JP2021543565 A JP 2021543565A JP 2021543565 A JP2021543565 A JP 2021543565A JP 7610515 B2 JP7610515 B2 JP 7610515B2
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antibody
seq
nt4x
antibodies
humanized
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JP2022513331A5 (enExample
JP2022513331A (ja
Inventor
トーマス バイエル
プリーティ バクラニア
サラ デイビス
アレックス ブラウン
チド ムパムハンガ
デビッド マシューズ
マーク カー
ガレス ホール
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LifeArc
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LifeArc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2021543565A 2018-10-04 2019-10-02 ヒト化抗Ｎ短縮型アミロイドβモノクローナル抗体 Active JP7610515B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201816210 2018-10-04
GB1816210.7 2018-10-04
PCT/EP2019/076772 WO2020070225A1 (en) 2018-10-04 2019-10-02 Humanised anti-n-truncated amyloid beta monoclonal antibody

Publications (3)

Publication Number Publication Date
JP2022513331A JP2022513331A (ja) 2022-02-07
JP2022513331A5 JP2022513331A5 (enExample) 2022-10-06
JP7610515B2 true JP7610515B2 (ja) 2025-01-08

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JP2021543565A Active JP7610515B2 (ja) 2018-10-04 2019-10-02 ヒト化抗Ｎ短縮型アミロイドβモノクローナル抗体

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Country Link
US (1) US12297261B2 (enExample)
EP (1) EP3861023A1 (enExample)
JP (1) JP7610515B2 (enExample)
KR (1) KR102862077B1 (enExample)
CN (1) CN113056480B (enExample)
BR (1) BR112021006153A2 (enExample)
EA (1) EA202190954A1 (enExample)
IL (1) IL281979B2 (enExample)
MX (1) MX2021003867A (enExample)
SG (1) SG11202102765RA (enExample)
WO (1) WO2020070225A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3658172A4 (en) 2017-07-25 2021-05-05 TrueBinding, Inc. TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND
CN113711036B (zh) 2019-01-30 2025-03-18 真和制药有限公司 抗gal3抗体及其用途
US20230151069A1 (en) 2020-03-10 2023-05-18 Lifearc Cyclic Peptides
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
EP4638494A1 (en) 2022-12-22 2025-10-29 BioArctic AB Antibody which binds to abetape3
TW202607032A (zh) 2024-06-20 2026-02-16 瑞典商生物極公司 雙特異性結合分子

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013167681A1 (en) 2012-05-10 2013-11-14 Georg-August-Universität Göttingen CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST Αβ OLIGOMERS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US474900A (en) 1892-05-17 William byrnes
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
PT2099826E (pt) 2007-01-05 2014-01-09 Univ Zuerich Anticorpo anti-beta-amilóide e suas utilizações
CA2703825A1 (en) 2007-10-29 2009-05-07 Innogenetics Nv New antibodies specific of the .beta.-amyloid peptides and their uses as diagnostic agents or drugs
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
WO2015173133A1 (en) * 2014-05-12 2015-11-19 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
CA2992386A1 (en) 2015-07-16 2017-01-19 Probiodrug Ag Humanized antibodies
CN111518206B (zh) * 2019-02-01 2022-03-29 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
US20230151069A1 (en) * 2020-03-10 2023-05-18 Lifearc Cyclic Peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013167681A1 (en) 2012-05-10 2013-11-14 Georg-August-Universität Göttingen CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST Αβ OLIGOMERS

Also Published As

Publication number Publication date
KR20210080400A (ko) 2021-06-30
AU2019354714A1 (en) 2021-04-29
EP3861023A1 (en) 2021-08-11
US12297261B2 (en) 2025-05-13
MX2021003867A (es) 2021-09-08
SG11202102765RA (en) 2021-04-29
US20210347867A1 (en) 2021-11-11
JP2022513331A (ja) 2022-02-07
CA3114669A1 (en) 2020-04-09
IL281979A (en) 2021-05-31
WO2020070225A1 (en) 2020-04-09
EA202190954A1 (ru) 2021-06-29
IL281979B2 (en) 2025-09-01
US20230203140A9 (en) 2023-06-29
IL281979B1 (en) 2025-05-01
BR112021006153A2 (pt) 2021-06-29
KR102862077B1 (ko) 2025-09-18
CN113056480A (zh) 2021-06-29
CN113056480B (zh) 2025-06-13

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