AU2019354714B9 - Humanised anti-N-truncated amyloid beta monoclonal antibody - Google Patents
Humanised anti-N-truncated amyloid beta monoclonal antibodyInfo
- Publication number
- AU2019354714B9 AU2019354714B9 AU2019354714A AU2019354714A AU2019354714B9 AU 2019354714 B9 AU2019354714 B9 AU 2019354714B9 AU 2019354714 A AU2019354714 A AU 2019354714A AU 2019354714 A AU2019354714 A AU 2019354714A AU 2019354714 B9 AU2019354714 B9 AU 2019354714B9
- Authority
- AU
- Australia
- Prior art keywords
- nt4x
- seq
- antibody
- binding
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201816210 | 2018-10-04 | ||
| GB1816210.7 | 2018-10-04 | ||
| PCT/EP2019/076772 WO2020070225A1 (en) | 2018-10-04 | 2019-10-02 | Humanised anti-n-truncated amyloid beta monoclonal antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2019354714A1 AU2019354714A1 (en) | 2021-04-29 |
| AU2019354714B2 AU2019354714B2 (en) | 2026-05-21 |
| AU2019354714B9 true AU2019354714B9 (en) | 2026-07-02 |
Family
ID=68136417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019354714A Active AU2019354714B9 (en) | 2018-10-04 | 2019-10-02 | Humanised anti-N-truncated amyloid beta monoclonal antibody |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12297261B2 (enExample) |
| EP (1) | EP3861023A1 (enExample) |
| JP (1) | JP7610515B2 (enExample) |
| KR (1) | KR102862077B1 (enExample) |
| CN (1) | CN113056480B (enExample) |
| AU (1) | AU2019354714B9 (enExample) |
| BR (1) | BR112021006153A2 (enExample) |
| EA (1) | EA202190954A1 (enExample) |
| IL (1) | IL281979B2 (enExample) |
| MX (1) | MX2021003867A (enExample) |
| SG (1) | SG11202102765RA (enExample) |
| WO (1) | WO2020070225A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| KR20210124308A (ko) | 2019-01-30 | 2021-10-14 | 트루바인딩 아이엔씨. | 항-gal3 항체 및 이의 용도 |
| CN115698060A (zh) | 2020-03-10 | 2023-02-03 | 生命爱科 | 环肽 |
| MX2022014786A (es) | 2020-05-26 | 2023-01-16 | Truebinding Inc | Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3. |
| WO2024133925A1 (en) | 2022-12-22 | 2024-06-27 | Bioarctic Ab | Antibody which binds to abetape3 |
| WO2025262228A1 (en) | 2024-06-20 | 2025-12-26 | Bioarctic Ab | Bispecific binding molecule |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013167681A1 (en) * | 2012-05-10 | 2013-11-14 | Georg-August-Universität Göttingen | CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST Αβ OLIGOMERS |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US474900A (en) | 1892-05-17 | William byrnes | ||
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| EP0279582A3 (en) | 1987-02-17 | 1989-10-18 | Pharming B.V. | Dna sequences to target proteins to the mammary gland for efficient secretion |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| HUE033325T2 (en) * | 2007-01-05 | 2017-11-28 | Univ Zuerich | Anti-beta-amyloid binder antibodies and their use |
| CN101883792B (zh) | 2007-10-29 | 2014-08-27 | 基因创新有限公司 | 特异于β-淀粉状蛋白肽的新抗体以及其用作诊断剂或药物的用途 |
| US8795664B2 (en) | 2010-06-04 | 2014-08-05 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Monoclonal antibodies targeting amyloid beta oligomers |
| WO2015173133A1 (en) | 2014-05-12 | 2015-11-19 | Chiesi Farmaceutici S.P.A. | Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy |
| NZ739181A (en) * | 2015-07-16 | 2023-05-26 | Vivoryon Therapeutics N V | Anti-pyroglutamated amyloid beta humanized antibodies |
| CN111518206B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| CN115698060A (zh) * | 2020-03-10 | 2023-02-03 | 生命爱科 | 环肽 |
-
2019
- 2019-10-02 KR KR1020217012796A patent/KR102862077B1/ko active Active
- 2019-10-02 SG SG11202102765RA patent/SG11202102765RA/en unknown
- 2019-10-02 JP JP2021543565A patent/JP7610515B2/ja active Active
- 2019-10-02 MX MX2021003867A patent/MX2021003867A/es unknown
- 2019-10-02 AU AU2019354714A patent/AU2019354714B9/en active Active
- 2019-10-02 EA EA202190954A patent/EA202190954A1/ru unknown
- 2019-10-02 WO PCT/EP2019/076772 patent/WO2020070225A1/en not_active Ceased
- 2019-10-02 IL IL281979A patent/IL281979B2/en unknown
- 2019-10-02 US US17/282,592 patent/US12297261B2/en active Active
- 2019-10-02 CN CN201980065883.5A patent/CN113056480B/zh active Active
- 2019-10-02 BR BR112021006153-3A patent/BR112021006153A2/pt unknown
- 2019-10-02 EP EP19782593.8A patent/EP3861023A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013167681A1 (en) * | 2012-05-10 | 2013-11-14 | Georg-August-Universität Göttingen | CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST Αβ OLIGOMERS |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113056480B (zh) | 2025-06-13 |
| CA3114669A1 (en) | 2020-04-09 |
| KR102862077B1 (ko) | 2025-09-18 |
| WO2020070225A1 (en) | 2020-04-09 |
| EA202190954A1 (ru) | 2021-06-29 |
| AU2019354714B2 (en) | 2026-05-21 |
| JP2022513331A (ja) | 2022-02-07 |
| MX2021003867A (es) | 2021-09-08 |
| AU2019354714A1 (en) | 2021-04-29 |
| CN113056480A (zh) | 2021-06-29 |
| IL281979B1 (en) | 2025-05-01 |
| IL281979B2 (en) | 2025-09-01 |
| US20230203140A9 (en) | 2023-06-29 |
| US12297261B2 (en) | 2025-05-13 |
| KR20210080400A (ko) | 2021-06-30 |
| EP3861023A1 (en) | 2021-08-11 |
| SG11202102765RA (en) | 2021-04-29 |
| JP7610515B2 (ja) | 2025-01-08 |
| IL281979A (en) | 2021-05-31 |
| US20210347867A1 (en) | 2021-11-11 |
| BR112021006153A2 (pt) | 2021-06-29 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SREP | Specification republished |