CN113056480B - 人源化抗N截短淀粉样β单克隆抗体 - Google Patents

人源化抗N截短淀粉样β单克隆抗体 Download PDF

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Publication number
CN113056480B
CN113056480B CN201980065883.5A CN201980065883A CN113056480B CN 113056480 B CN113056480 B CN 113056480B CN 201980065883 A CN201980065883 A CN 201980065883A CN 113056480 B CN113056480 B CN 113056480B
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leu
val
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CN201980065883.5A
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Chinese (zh)
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CN113056480A (zh
Inventor
T·拜耳
P·巴克拉尼亚
S·戴维斯
A·布朗
C·姆帕曼加
D·马修斯
M·卡尔
G·霍尔
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Life Agco
George Auguste Gottingen University Public Law University Medical Foundation
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Life Agco
George Auguste Gottingen University Public Law University Medical Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980065883.5A 2018-10-04 2019-10-02 人源化抗N截短淀粉样β单克隆抗体 Active CN113056480B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201816210 2018-10-04
GB1816210.7 2018-10-04
PCT/EP2019/076772 WO2020070225A1 (en) 2018-10-04 2019-10-02 Humanised anti-n-truncated amyloid beta monoclonal antibody

Publications (2)

Publication Number Publication Date
CN113056480A CN113056480A (zh) 2021-06-29
CN113056480B true CN113056480B (zh) 2025-06-13

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CN201980065883.5A Active CN113056480B (zh) 2018-10-04 2019-10-02 人源化抗N截短淀粉样β单克隆抗体

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Country Link
US (1) US12297261B2 (enExample)
EP (1) EP3861023A1 (enExample)
JP (1) JP7610515B2 (enExample)
KR (1) KR102862077B1 (enExample)
CN (1) CN113056480B (enExample)
AU (1) AU2019354714B9 (enExample)
BR (1) BR112021006153A2 (enExample)
EA (1) EA202190954A1 (enExample)
IL (1) IL281979B2 (enExample)
MX (1) MX2021003867A (enExample)
SG (1) SG11202102765RA (enExample)
WO (1) WO2020070225A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
CN115698060A (zh) 2020-03-10 2023-02-03 生命爱科 环肽
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
WO2024133925A1 (en) 2022-12-22 2024-06-27 Bioarctic Ab Antibody which binds to abetape3
WO2025262228A1 (en) 2024-06-20 2025-12-26 Bioarctic Ab Bispecific binding molecule

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111518206A (zh) * 2019-02-01 2020-08-11 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
CN115698060A (zh) * 2020-03-10 2023-02-03 生命爱科 环肽

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US474900A (en) 1892-05-17 William byrnes
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
HUE033325T2 (en) * 2007-01-05 2017-11-28 Univ Zuerich Anti-beta-amyloid binder antibodies and their use
CN101883792B (zh) 2007-10-29 2014-08-27 基因创新有限公司 特异于β-淀粉状蛋白肽的新抗体以及其用作诊断剂或药物的用途
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
DK3269736T3 (da) * 2012-05-10 2020-01-13 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Konformationsspecifikke antistoffer mod oligomerer af amyloid beta
WO2015173133A1 (en) 2014-05-12 2015-11-19 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
NZ739181A (en) * 2015-07-16 2023-05-26 Vivoryon Therapeutics N V Anti-pyroglutamated amyloid beta humanized antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111518206A (zh) * 2019-02-01 2020-08-11 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
CN115698060A (zh) * 2020-03-10 2023-02-03 生命爱科 环肽

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Discovery of a novel pseudoβ-hairpin structure of N-truncated amyloid-βfor use as a vaccine against Alzheimer’s disease;Preeti Bakrania 等;《Molecular Psychiatry》;20211115;840-848 *

Also Published As

Publication number Publication date
CA3114669A1 (en) 2020-04-09
KR102862077B1 (ko) 2025-09-18
WO2020070225A1 (en) 2020-04-09
EA202190954A1 (ru) 2021-06-29
AU2019354714B2 (en) 2026-05-21
JP2022513331A (ja) 2022-02-07
MX2021003867A (es) 2021-09-08
AU2019354714A1 (en) 2021-04-29
CN113056480A (zh) 2021-06-29
IL281979B1 (en) 2025-05-01
IL281979B2 (en) 2025-09-01
US20230203140A9 (en) 2023-06-29
US12297261B2 (en) 2025-05-13
KR20210080400A (ko) 2021-06-30
AU2019354714B9 (en) 2026-07-02
EP3861023A1 (en) 2021-08-11
SG11202102765RA (en) 2021-04-29
JP7610515B2 (ja) 2025-01-08
IL281979A (en) 2021-05-31
US20210347867A1 (en) 2021-11-11
BR112021006153A2 (pt) 2021-06-29

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