JP7609790B2 - イミダゾピリジニル化合物及び神経変性障害の処置のためのその使用 - Google Patents

イミダゾピリジニル化合物及び神経変性障害の処置のためのその使用 Download PDF

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Publication number
JP7609790B2
JP7609790B2 JP2021549327A JP2021549327A JP7609790B2 JP 7609790 B2 JP7609790 B2 JP 7609790B2 JP 2021549327 A JP2021549327 A JP 2021549327A JP 2021549327 A JP2021549327 A JP 2021549327A JP 7609790 B2 JP7609790 B2 JP 7609790B2
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fluoro
pyridin
imidazo
carboxamide
methylphenyl
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JP2022521536A (ja
JP2022521536A5 (https=
Inventor
イ，ジンファ
チョ，スヨン
イム，キョンスン
パク，アヨン
キム，ジェウン
キム，ミスン
イム，スンムク
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1St Biotherapeutics Inc
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1St Biotherapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2021549327A 2019-02-22 2020-02-21 イミダゾピリジニル化合物及び神経変性障害の処置のためのその使用 Active JP7609790B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962809230P 2019-02-22 2019-02-22
US62/809,230 2019-02-22
PCT/IB2020/051469 WO2020170205A1 (en) 2019-02-22 2020-02-21 Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders

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JP2022521536A JP2022521536A (ja) 2022-04-08
JP2022521536A5 JP2022521536A5 (https=) 2023-03-01
JP7609790B2 true JP7609790B2 (ja) 2025-01-07

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JP2021549328A Pending JP2022521537A (ja) 2019-02-22 2020-02-21 イミダゾピリジニル化合物及び増殖性障害の処置のためのその使用

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US (4) US20220242861A1 (https=)
EP (2) EP3927706A4 (https=)
JP (2) JP7609790B2 (https=)
KR (2) KR102892275B1 (https=)
CN (2) CN113454081B (https=)
AU (1) AU2020224401A1 (https=)
CA (1) CA3131059A1 (https=)
IL (1) IL285708B2 (https=)
MX (1) MX2021010122A (https=)
WO (2) WO2020170205A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023539197A (ja) * 2020-08-21 2023-09-13 ファースト・バイオセラピューティクス・インコーポレイテッド Ｐｅｔ放射性トレーサとしての［１８ｆ］標識イミダゾピリジン誘導体

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AU2020224401A1 (en) 2019-02-22 2021-10-14 1ST Biotherapeutics, Inc. Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
US12398156B2 (en) 2020-08-21 2025-08-26 1ST Biotherapeutics, Inc. Compounds for prevention or treatment of neurodegenerative disorders
WO2022064459A1 (en) * 2020-09-28 2022-03-31 1ST Biotherapeutics, Inc. Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same
EP4236950A4 (en) * 2020-10-29 2024-10-23 Merck Sharp & Dohme LLC N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
WO2022165529A1 (en) * 2021-02-01 2022-08-04 Janssen Biotech, Inc. Small molecule inhibitors of salt inducible kinases
CN115724839A (zh) * 2021-08-26 2023-03-03 科辉智药生物科技(深圳)有限公司 Sarm1酶活性抑制剂及其应用
EP4499643A4 (en) * 2022-03-25 2026-01-28 1St Biotherapeutics Inc INDAZOLES USED AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND THEIR METHODS OF USE
CN116354959B (zh) * 2023-03-10 2024-04-19 石河子大学 一种N-N桥连噻唑单元的β-咔啉衍生物及其制备方法、应用
CN121941688A (zh) * 2023-10-09 2026-04-28 浙江海正药业股份有限公司 多取代芳基类衍生物及其制备方法和用途

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JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2010536796A (ja) 2007-08-17 2010-12-02 アイカジェン， インコーポレイテッド カリウムチャネル調節物質としての複素環
JP2012530071A (ja) 2009-06-12 2012-11-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 縮合複素環式化合物およびそれらの使用
JP2013502423A (ja) 2009-08-17 2013-01-24 インテリカイン， エルエルシー 複素環式化合物およびそれらの使用
JP2014502601A (ja) 2010-12-17 2014-02-03 エフ．ホフマン−ラ ロシュ アーゲー 置換６，６−縮合窒素複素環化合物及びその使用
WO2015134171A1 (en) 2014-03-06 2015-09-11 Takeda Pharmaceutical Company Limited Heteroarylamide inhibitors of tbk1
WO2018017435A1 (en) 2016-07-22 2018-01-25 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of necrosis, composition and application thereof
WO2018237370A1 (en) 2017-06-23 2018-12-27 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of necrosis, composition and method using the same
JP2022521537A (ja) 2019-02-22 2022-04-08 ファースト・バイオセラピューティクス・インコーポレイテッド イミダゾピリジニル化合物及び増殖性障害の処置のためのその使用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023539197A (ja) * 2020-08-21 2023-09-13 ファースト・バイオセラピューティクス・インコーポレイテッド Ｐｅｔ放射性トレーサとしての［１８ｆ］標識イミダゾピリジン誘導体
JP7773233B2 (ja) 2020-08-21 2025-11-19 ファースト・バイオセラピューティクス・インコーポレイテッド Ｐｅｔ放射性トレーサとしての［１８ｆ］標識イミダゾピリジン誘導体

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US20210347774A1 (en) 2021-11-11
WO2020170205A1 (en) 2020-08-27
MX2021010122A (es) 2021-09-23
IL285708A (en) 2021-10-31
CN113454081A (zh) 2021-09-28
CN113454082A (zh) 2021-09-28
IL285708B2 (en) 2025-02-01
US20200270246A1 (en) 2020-08-27
AU2020224401A1 (en) 2021-10-14
US11098044B2 (en) 2021-08-24
EP3927706A4 (en) 2022-12-14
US12534461B2 (en) 2026-01-27
CA3131059A1 (en) 2020-08-27
KR20210122862A (ko) 2021-10-12
CN113454082B (zh) 2024-07-02
US11802126B2 (en) 2023-10-31
EP3927705A1 (en) 2021-12-29
KR102892275B1 (ko) 2025-11-27
KR20210122861A (ko) 2021-10-12
US20220242861A1 (en) 2022-08-04
JP2022521536A (ja) 2022-04-08
JP2022521537A (ja) 2022-04-08
CN113454081B (zh) 2024-08-09
US20230365557A1 (en) 2023-11-16
WO2020170206A1 (en) 2020-08-27
IL285708B1 (en) 2024-10-01
EP3927706A1 (en) 2021-12-29
EP3927705A4 (en) 2022-12-07

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