JP7595648B2 - デジタルマイクロ流体デバイスの温度制御 - Google Patents
デジタルマイクロ流体デバイスの温度制御 Download PDFInfo
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- JP7595648B2 JP7595648B2 JP2022513568A JP2022513568A JP7595648B2 JP 7595648 B2 JP7595648 B2 JP 7595648B2 JP 2022513568 A JP2022513568 A JP 2022513568A JP 2022513568 A JP2022513568 A JP 2022513568A JP 7595648 B2 JP7595648 B2 JP 7595648B2
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K1/00—Details of thermometers not specially adapted for particular types of thermometer
- G01K1/02—Means for indicating or recording specially adapted for thermometers
- G01K1/026—Means for indicating or recording specially adapted for thermometers arrangements for monitoring a plurality of temperatures, e.g. by multiplexing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B2203/00—Integrated processes for the production of hydrogen or synthesis gas
- C01B2203/16—Controlling the process
- C01B2203/1614—Controlling the temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K2217/00—Temperature measurement using electric or magnetic components already present in the system to be measured
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962893091P | 2019-08-28 | 2019-08-28 | |
| US62/893,091 | 2019-08-28 | ||
| PCT/CN2020/111570 WO2021037094A1 (en) | 2019-08-28 | 2020-08-27 | Temperature control on digital microfluidics device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022547439A JP2022547439A (ja) | 2022-11-14 |
| JP2022547439A5 JP2022547439A5 (https=) | 2023-08-30 |
| JP7595648B2 true JP7595648B2 (ja) | 2024-12-06 |
Family
ID=74684614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513568A Active JP7595648B2 (ja) | 2019-08-28 | 2020-08-27 | デジタルマイクロ流体デバイスの温度制御 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11660602B2 (https=) |
| EP (1) | EP4022031A4 (https=) |
| JP (1) | JP7595648B2 (https=) |
| CN (1) | CN114364785A (https=) |
| WO (1) | WO2021037094A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114364785A (zh) | 2019-08-28 | 2022-04-15 | 深圳华大基因科技有限公司 | 对数字微流控设备的温度控制 |
| CN112791753B (zh) * | 2019-11-13 | 2022-05-24 | 京东方科技集团股份有限公司 | 微流控芯片及其制造方法、微流控器件 |
| CN113751089A (zh) * | 2021-09-02 | 2021-12-07 | 厦门大学 | 一种集成有加热模块的数字微流控芯片 |
| CN114100716B (zh) * | 2021-12-01 | 2023-04-21 | 上海天马微电子有限公司 | 微流控装置及其驱动方法 |
| TWI810990B (zh) * | 2022-06-27 | 2023-08-01 | 友達光電股份有限公司 | 微流體晶片及其使用方法 |
| CN116731841A (zh) * | 2022-11-10 | 2023-09-12 | 南方科技大学 | 微针加热扩增结构、快速核酸检测芯片、装置与方法 |
| CN117742410B (zh) * | 2023-12-26 | 2024-11-15 | 首都医科大学附属北京儿童医院 | 一种温控系统及微流控芯片检测系统 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110048951A1 (en) | 2007-06-27 | 2011-03-03 | Digital Biosystems | Digital microfluidics based apparatus for heat-exchanging chemical processes |
| JP2016539343A (ja) | 2013-08-30 | 2016-12-15 | イルミナ インコーポレイテッド | 親水性または斑状親水性表面上の液滴の操作 |
| JP2018512884A (ja) | 2015-04-24 | 2018-05-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デジタルマイクロ流体技術を用いたデジタルｐｃｒシステム及び方法 |
| US20180178217A1 (en) | 2015-06-05 | 2018-06-28 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| US20180264427A1 (en) | 2009-11-25 | 2018-09-20 | Gen9, Inc. | Microfluidic devices and methods for gene synthesis |
| WO2018200872A1 (en) | 2017-04-26 | 2018-11-01 | Berkeley Lights, Inc. | Biological process systems and methods using microfluidic apparatus having an optimized electrowetting surface |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6494616B1 (en) * | 2000-08-04 | 2002-12-17 | Regents Of The University Of Minnesota | Multiplexed sensor array |
| US8735103B2 (en) * | 2006-12-05 | 2014-05-27 | Electronics And Telecommunications Research Institute | Natural convection-driven PCR apparatus and method using disposable polymer chip |
| US8940147B1 (en) * | 2011-04-25 | 2015-01-27 | Sandia Corporation | Microfluidic hubs, systems, and methods for interface fluidic modules |
| US9797007B2 (en) * | 2012-11-30 | 2017-10-24 | Suzhou Institute Of Nano-Tech And Nano-Bionics Of Chinese Academy Of Science | Micro-liquid phase reaction method based on substrate with hydrophilic-hydrophobic patterned surface |
| CN104248997B (zh) * | 2013-06-27 | 2016-07-27 | 李木 | 一种数字式微流控芯片及其控制方法 |
| CA2846963A1 (en) * | 2014-03-14 | 2015-09-14 | Karan Kaler | Droplet-based microfluidic device and methods for producing and using the same |
| US11915795B2 (en) * | 2016-12-23 | 2024-02-27 | The Regents Of The University Of California | Method and device for digital high resolution melt |
| WO2018138993A1 (ja) * | 2017-01-30 | 2018-08-02 | 株式会社村田製作所 | 温度センサ |
| US10695761B2 (en) * | 2017-05-30 | 2020-06-30 | Sharp Life Science (Eu) Limited | Microfluidic device with multiple temperature zones and enhanced temperature control |
| WO2020026200A1 (en) | 2018-08-02 | 2020-02-06 | Mgi Tech Co., Ltd. | Apparatus and method for forming droplets having predetermined volume by electrowetting |
| CN109536384B (zh) | 2018-12-24 | 2022-02-18 | 中国科学院上海微系统与信息技术研究所 | 一种用于核酸快速绝对定量的数字pcr系统及其应用 |
| CN114364785A (zh) | 2019-08-28 | 2022-04-15 | 深圳华大基因科技有限公司 | 对数字微流控设备的温度控制 |
-
2020
- 2020-08-27 CN CN202080061054.2A patent/CN114364785A/zh active Pending
- 2020-08-27 JP JP2022513568A patent/JP7595648B2/ja active Active
- 2020-08-27 EP EP20858617.2A patent/EP4022031A4/en active Pending
- 2020-08-27 WO PCT/CN2020/111570 patent/WO2021037094A1/en not_active Ceased
- 2020-08-27 US US17/004,614 patent/US11660602B2/en active Active
-
2023
- 2023-04-18 US US18/302,183 patent/US11980885B2/en active Active
-
2024
- 2024-04-12 US US18/633,852 patent/US12269038B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110048951A1 (en) | 2007-06-27 | 2011-03-03 | Digital Biosystems | Digital microfluidics based apparatus for heat-exchanging chemical processes |
| US20180264427A1 (en) | 2009-11-25 | 2018-09-20 | Gen9, Inc. | Microfluidic devices and methods for gene synthesis |
| JP2016539343A (ja) | 2013-08-30 | 2016-12-15 | イルミナ インコーポレイテッド | 親水性または斑状親水性表面上の液滴の操作 |
| JP2018512884A (ja) | 2015-04-24 | 2018-05-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デジタルマイクロ流体技術を用いたデジタルｐｃｒシステム及び方法 |
| US20180178217A1 (en) | 2015-06-05 | 2018-06-28 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| WO2018200872A1 (en) | 2017-04-26 | 2018-11-01 | Berkeley Lights, Inc. | Biological process systems and methods using microfluidic apparatus having an optimized electrowetting surface |
Also Published As
| Publication number | Publication date |
|---|---|
| US20230249186A1 (en) | 2023-08-10 |
| US11980885B2 (en) | 2024-05-14 |
| EP4022031A1 (en) | 2022-07-06 |
| US11660602B2 (en) | 2023-05-30 |
| CN114364785A (zh) | 2022-04-15 |
| EP4022031A4 (en) | 2023-09-27 |
| US20240253046A1 (en) | 2024-08-01 |
| WO2021037094A1 (en) | 2021-03-04 |
| JP2022547439A (ja) | 2022-11-14 |
| US20210114034A1 (en) | 2021-04-22 |
| US12269038B2 (en) | 2025-04-08 |
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