JP7593646B2 - Ｂａｆｆ－ｒ／ｃｄ１９を標的としたキメラ抗原受容体修飾ｔ細胞とその使用 - Google Patents

Ｂａｆｆ－ｒ／ｃｄ１９を標的としたキメラ抗原受容体修飾ｔ細胞とその使用 Download PDF

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JP7593646B2
JP7593646B2 JP2021548701A JP2021548701A JP7593646B2 JP 7593646 B2 JP7593646 B2 JP 7593646B2 JP 2021548701 A JP2021548701 A JP 2021548701A JP 2021548701 A JP2021548701 A JP 2021548701A JP 7593646 B2 JP7593646 B2 JP 7593646B2
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baff
scfv
chain variable
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JP2022521240A (ja
JP2022521240A5 (cg-RX-API-DMAC10.html
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チン，ホン
ワン，シウリ
ウォンシン クワック，ラリー
ジェイ． フォーマン，スティーブン
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City of Hope
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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JP2021548701A 2019-02-20 2020-02-20 Ｂａｆｆ－ｒ／ｃｄ１９を標的としたキメラ抗原受容体修飾ｔ細胞とその使用 Active JP7593646B2 (ja)

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Application Number Priority Date Filing Date Title
US201962808222P 2019-02-20 2019-02-20
US62/808,222 2019-02-20
PCT/US2020/019082 WO2020172440A1 (en) 2019-02-20 2020-02-20 Baff-r/cd19 targeted chimeric antigen receptor-modified t cells and use thereof

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JP2022521240A JP2022521240A (ja) 2022-04-06
JP2022521240A5 JP2022521240A5 (cg-RX-API-DMAC10.html) 2023-02-13
JP7593646B2 true JP7593646B2 (ja) 2024-12-03

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US (1) US12545714B2 (cg-RX-API-DMAC10.html)
EP (1) EP3927738A1 (cg-RX-API-DMAC10.html)
JP (1) JP7593646B2 (cg-RX-API-DMAC10.html)
KR (1) KR20210129125A (cg-RX-API-DMAC10.html)
CN (1) CN113874391B (cg-RX-API-DMAC10.html)
WO (1) WO2020172440A1 (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022515152A (ja) * 2018-12-19 2022-02-17 シティ・オブ・ホープ Ｂａｆｆ－ｒ二重特異性ｔ細胞エンゲージャー抗体
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
WO2021163989A1 (en) * 2020-02-21 2021-08-26 Yinnuolai Biotech Ltd. Anti-baff receptor antibodies and uses thereof
CA3203531A1 (en) 2020-12-30 2022-07-07 Simon Olivares Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
CA3257911A1 (en) * 2022-06-01 2023-12-07 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Recombinant receptors binding to the B-cell activating factor receptor and their uses
US20260207667A1 (en) * 2022-12-13 2026-07-23 Juno Therapeutics, Inc. Chimeric antigen receptors specific for baff-r and cd19 and methods and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149578A1 (en) 2015-03-19 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dual specific anti-cd22-anti-cd19 chimeric antigen receptors
WO2017214170A2 (en) 2016-06-06 2017-12-14 City Of Hope Baff-r antibodies and uses thereof
WO2017214167A1 (en) 2016-06-06 2017-12-14 City Of Hope Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof
CN108728459A (zh) 2017-04-24 2018-11-02 上海恒润达生生物科技有限公司 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途
WO2018213337A1 (en) 2017-05-15 2018-11-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors and their uses
WO2018237022A1 (en) 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
DE102014105472B4 (de) 2014-04-16 2016-03-17 Sartorius Stedim Biotech Gmbh Misch- und Auftauvorrichtung
US20170158749A1 (en) 2014-04-23 2017-06-08 Board Of Regents, The University Of Texas System Chimeric antigen receptors (car) and methods for making and using the same
TWI751102B (zh) 2014-08-28 2022-01-01 美商奇諾治療有限公司 對ｃｄ１９具專一性之抗體及嵌合抗原受體
MX2018001568A (es) 2015-08-07 2019-04-25 Seattle Children´S Hospital Dba Seattle Children´S Res Institute Celulas t biespecificas de receptor quimerico de antigeno (car) para focalizacion a tumores solidos.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149578A1 (en) 2015-03-19 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dual specific anti-cd22-anti-cd19 chimeric antigen receptors
WO2017214170A2 (en) 2016-06-06 2017-12-14 City Of Hope Baff-r antibodies and uses thereof
WO2017214167A1 (en) 2016-06-06 2017-12-14 City Of Hope Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof
CN108728459A (zh) 2017-04-24 2018-11-02 上海恒润达生生物科技有限公司 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途
WO2018213337A1 (en) 2017-05-15 2018-11-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors and their uses
WO2018237022A1 (en) 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
British Journal of Haematology，2018年，Vol.182，pp.939-943

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JP2022521240A (ja) 2022-04-06
CN113874391A (zh) 2021-12-31
CN113874391B (zh) 2025-10-28
WO2020172440A1 (en) 2020-08-27
US12545714B2 (en) 2026-02-10
EP3927738A1 (en) 2021-12-29
KR20210129125A (ko) 2021-10-27
US20220125840A1 (en) 2022-04-28

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