JP7578704B2 - Ｋｖ１．３カリウムシェーカーチャネル遮断薬としてのアリールメチレン複素環式化合物 - Google Patents

Ｋｖ１．３カリウムシェーカーチャネル遮断薬としてのアリールメチレン複素環式化合物 Download PDF

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JP7578704B2
JP7578704B2 JP2022546589A JP2022546589A JP7578704B2 JP 7578704 B2 JP7578704 B2 JP 7578704B2 JP 2022546589 A JP2022546589 A JP 2022546589A JP 2022546589 A JP2022546589 A JP 2022546589A JP 7578704 B2 JP7578704 B2 JP 7578704B2
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ジョルダネット，ファブリツィオ
エステルガールド イェンセン，モルテン
ジョギーニ，ビシュワナス
ジョン スノウ，ロジャー
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ディー．イー．ショウ リサーチ，エルエルシー
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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MX2023003841A (es) 2020-10-06 2023-06-23 De Shaw Res Llc Compuestos lactámicos como bloqueadores del canal agitador de potasio kv1.3.
EP4351569A4 (en) 2021-05-28 2025-04-16 D.E. Shaw Research, LLC Spiroindolinone compounds as kv1.3 potassium shaker channel blockers
WO2023122325A2 (en) * 2021-12-23 2023-06-29 Regents Of The University Of Michigan Meta anilide compounds and methods for use of the same to treat diseases and disorders
WO2024088343A1 (zh) * 2022-10-28 2024-05-02 上海深势唯思科技有限责任公司 一种芳基杂环类Kv1.3抑制剂及其制备方法和用途
WO2025017105A1 (en) * 2023-07-18 2025-01-23 Muna Therapeutics Aps Kv1.3 potassium channel antagonists
AR133292A1 (es) * 2023-07-18 2025-09-17 Muna Therapeutics Aps Antagonistas del canal de potasio kv1.3
TW202521512A (zh) 2023-07-31 2025-06-01 美商美國禮來大藥廠 Kv1.3鉀shaker通道阻斷劑之固體形式及其使用方法
CN117105996B (zh) * 2023-10-24 2024-02-06 北京瑞博奥医药科技有限公司 一种脱氧核糖衍生物的制备的方法

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