JP7551610B2 - Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用 - Google Patents

Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用 Download PDF

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JP7551610B2
JP7551610B2 JP2021527829A JP2021527829A JP7551610B2 JP 7551610 B2 JP7551610 B2 JP 7551610B2 JP 2021527829 A JP2021527829 A JP 2021527829A JP 2021527829 A JP2021527829 A JP 2021527829A JP 7551610 B2 JP7551610 B2 JP 7551610B2
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Japan
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optionally substituted
alkyl
group
alkylene
compound
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Japanese (ja)
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JP2022507776A (ja
JP2022507776A5 (https=
Inventor
ロジャー ビー． クラーク，
リチャード アルム，
ウェスリー フランシス オースティン，
フィリップ ホーガン，
アイヴァン ジェウェット，
サスミタ ディー． ラヒリ，
ジョナサン エフ． ローレンス，
シベン リー，
シュハオ シ，
ウェンイン ワン，
幸孝 市川
アンドリュー ジー． マイアーズ，
ジヤン ジャン，
ピーター ニールス カールセン，
アンドレ サンチェス，
ガナパシー ダンダパニ，
スリムルトゥル ニーティパリ，
エムディー． アタウル ラーマン，
トーマス ルピトル，
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Harvard University
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Harvard University
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Publication of JP2022507776A publication Critical patent/JP2022507776A/ja
Publication of JP2022507776A5 publication Critical patent/JP2022507776A5/ja
Priority to JP2024152316A priority Critical patent/JP2025000636A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2021527829A 2018-11-19 2019-11-18 Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用 Active JP7551610B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024152316A JP2025000636A (ja) 2018-11-19 2024-09-04 Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769383P 2018-11-19 2018-11-19
US62/769,383 2018-11-19
PCT/US2019/062030 WO2020106627A1 (en) 2018-11-19 2019-11-18 C10-alkylene substituted 13-membered macrolides and uses thereof

Related Child Applications (1)

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JP2024152316A Division JP2025000636A (ja) 2018-11-19 2024-09-04 Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用

Publications (3)

Publication Number Publication Date
JP2022507776A JP2022507776A (ja) 2022-01-18
JP2022507776A5 JP2022507776A5 (https=) 2022-11-29
JP7551610B2 true JP7551610B2 (ja) 2024-09-17

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ID=68916562

Family Applications (2)

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JP2021527829A Active JP7551610B2 (ja) 2018-11-19 2019-11-18 Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用
JP2024152316A Pending JP2025000636A (ja) 2018-11-19 2024-09-04 Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用

Family Applications After (1)

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JP2024152316A Pending JP2025000636A (ja) 2018-11-19 2024-09-04 Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用

Country Status (19)

Country Link
US (1) US12552825B2 (https=)
EP (2) EP4737470A2 (https=)
JP (2) JP7551610B2 (https=)
KR (1) KR102929869B1 (https=)
CN (1) CN113573779A (https=)
AU (1) AU2019385333B2 (https=)
BR (1) BR112021009624A2 (https=)
CA (1) CA3120148A1 (https=)
DK (1) DK3883647T3 (https=)
ES (1) ES3063764T3 (https=)
FI (1) FI3883647T3 (https=)
IL (1) IL283194B2 (https=)
LT (1) LT3883647T (https=)
MX (1) MX2021005423A (https=)
PT (1) PT3883647T (https=)
SG (1) SG11202105227QA (https=)
SI (1) SI3883647T1 (https=)
SM (1) SMT202600094T1 (https=)
WO (1) WO2020106627A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313065A (zh) * 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023250513A1 (en) * 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
CN120152721A (zh) 2022-09-01 2025-06-13 齐卡尼治疗股份有限公司 使用13元大环内酯治疗家族性腺瘤性息肉病

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031097A1 (en) 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents
WO2003014136A1 (en) 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
WO2007091393A1 (ja) 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. １０ａ－アザライド化合物
WO2012001089A1 (en) 2010-07-01 2012-01-05 Novartis Ag Antibiotic compositions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
NZ526120A (en) * 1999-11-09 2005-02-25 Pfizer Prod Inc 13-membered azalides and their use as antibiotic agents
BR0110382A (pt) * 2000-04-27 2003-06-24 Pfizer Prod Inc Utilização de composições antibióticas azalida para o tratamento ou prevenção de uma infecção causada por bactérias ou protozoários em mamìferos
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
RU2008106915A (ru) * 2005-07-26 2009-09-10 Меркле Гмбх (De) Макролидные конъюгаты пирролиновых и индолизиновых соединений
WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN106998685A (zh) 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
EP3273969A4 (en) * 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
WO2016154533A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Synthesis of desosamines
US20180273573A1 (en) * 2015-10-01 2018-09-27 Memorial Sloan-Kettering Cancer Center Inhibitors of menaquinone biosynthesis
WO2018201076A2 (en) 2017-04-28 2018-11-01 Macrolide Pharmaceuticals Inc. Macrolides with modified desosamine sugars and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031097A1 (en) 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents
WO2003014136A1 (en) 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
WO2007091393A1 (ja) 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. １０ａ－アザライド化合物
WO2012001089A1 (en) 2010-07-01 2012-01-05 Novartis Ag Antibiotic compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahedron，53，1997年，16923-16944

Also Published As

Publication number Publication date
SG11202105227QA (en) 2021-06-29
DK3883647T3 (da) 2026-03-23
SI3883647T1 (sl) 2026-04-30
MX2021005423A (es) 2021-09-08
ES3063764T3 (en) 2026-04-20
IL283194A (en) 2021-06-30
IL283194B1 (en) 2024-11-01
PT3883647T (pt) 2026-02-26
EP3883647B1 (en) 2026-02-11
KR20210133950A (ko) 2021-11-08
JP2022507776A (ja) 2022-01-18
EP3883647A1 (en) 2021-09-29
IL283194B2 (en) 2025-03-01
SMT202600094T1 (it) 2026-03-09
US20230093692A1 (en) 2023-03-23
AU2019385333A1 (en) 2021-07-01
CN113573779A (zh) 2021-10-29
US12552825B2 (en) 2026-02-17
KR102929869B1 (ko) 2026-02-23
CA3120148A1 (en) 2020-05-28
AU2019385333B2 (en) 2025-04-17
LT3883647T (lt) 2026-03-25
EP4737470A2 (en) 2026-05-06
JP2025000636A (ja) 2025-01-07
FI3883647T3 (fi) 2026-03-25
BR112021009624A2 (pt) 2021-08-10
WO2020106627A1 (en) 2020-05-28

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