JP7546582B2 - 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 - Google Patents

治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 Download PDF

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JP7546582B2
JP7546582B2 JP2021549565A JP2021549565A JP7546582B2 JP 7546582 B2 JP7546582 B2 JP 7546582B2 JP 2021549565 A JP2021549565 A JP 2021549565A JP 2021549565 A JP2021549565 A JP 2021549565A JP 7546582 B2 JP7546582 B2 JP 7546582B2
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トニー ペレド
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ガミダ セル リミテッド
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JP2021549565A 2019-02-24 2020-02-24 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 Active JP7546582B2 (ja)

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US201962809671P 2019-02-24 2019-02-24
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PCT/IL2020/050206 WO2020170260A1 (en) 2019-02-24 2020-02-24 Method of homing and retention of gammadelta t cells for generating cell compositions for use in therapy

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JP2024060371A Pending JP2024088717A (ja) 2019-02-24 2024-04-03 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024088717A (ja) * 2019-02-24 2024-07-02 ガミダ セル リミテッド 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023069322A1 (en) * 2021-10-20 2023-04-27 University Of Pittsburgh – Of The Commonwealth System Of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
AU2024210701A1 (en) * 2023-01-17 2025-07-31 Ansun Biopharma, Inc. Methods of producing gamma delta t cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013515497A (ja) 2009-12-29 2013-05-09 ガミダ セル リミテッド ナチュラルキラー細胞の増殖および活性の強化方法
JP2016539929A (ja) 2013-10-25 2016-12-22 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 免疫療法のためのポリクローナルγδT細胞

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846393B2 (en) * 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
CN102154205A (zh) * 2011-01-31 2011-08-17 郑骏年 高纯度、高细胞毒活性的γδT细胞的制备方法
RU2756247C2 (ru) * 2014-11-17 2021-09-28 Эдисет Био, Инк. Генетически модифицированные гамма дельта т-клетки
KR102929174B1 (ko) * 2015-10-30 2026-02-20 더 리전츠 오브 더 유니버시티 오브 캘리포니아 줄기세포로부터 t-세포를 생산하는 방법 및 상기 t-세포를 이용한 면역치료 방법
JP7212615B2 (ja) * 2016-10-05 2023-01-25 フジフィルム セルラー ダイナミクス,インコーポレイテッド 多能性幹細胞からhlaホモ接合免疫細胞への指向分化方法
US10731128B2 (en) * 2016-11-22 2020-08-04 Alloplex Biotherapeutics, Inc. Compositions and methods for in vitro activation and expansion of serial killer T cell populations and passive immunization of a cancer patient with tumor cell killing cells
US12440578B2 (en) * 2017-02-22 2025-10-14 Io Biosciences, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
CN107164322A (zh) * 2017-07-05 2017-09-15 泰山医学院附属医院 一种用于人γδT细胞扩增的培养基及其制备方法
CN108949685B (zh) * 2018-08-02 2022-03-29 吉林大学第一医院 一种体外诱导扩增高杀伤活性γδT细胞的方法
EP3927353A4 (en) * 2019-02-24 2022-11-23 Gamida-Cell Ltd. METHOD OF ECOTAXY AND RETENTION OF GAMMADELTA T LYMPHOCYTES, OPTIONALLY WITH NATURAL KILLER CELLS, ALLOWING THE GENERATION OF CELLULAR COMPOSITIONS FOR USE IN THERAPY

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013515497A (ja) 2009-12-29 2013-05-09 ガミダ セル リミテッド ナチュラルキラー細胞の増殖および活性の強化方法
JP2016539929A (ja) 2013-10-25 2016-12-22 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 免疫療法のためのポリクローナルγδT細胞

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EBioMedicine,2018年12月07日,Vol.39,pp.44-58
Experimental Hematology,2012年,Vol.40,pp.342-355
Microbes and Infection,2005年,Vol.7,pp.510-517

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024088717A (ja) * 2019-02-24 2024-07-02 ガミダ セル リミテッド 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法

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AU2020225597A1 (en) 2021-10-07
KR20210133996A (ko) 2021-11-08
IL285806A (en) 2021-10-31
SG11202109055UA (en) 2021-09-29
EP3927353A1 (en) 2021-12-29
IL285806B1 (en) 2025-01-01
EP3927353A4 (en) 2022-11-23
CA3130442A1 (en) 2020-08-27
CN113710257A (zh) 2021-11-26
BR112021016698A2 (pt) 2021-10-13
JP2024088717A (ja) 2024-07-02

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