JP7518765B2 - Ｄ－セリンの重水素化類似体およびその使用 - Google Patents

Ｄ－セリンの重水素化類似体およびその使用 Download PDF

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Publication number
JP7518765B2
JP7518765B2 JP2020528027A JP2020528027A JP7518765B2 JP 7518765 B2 JP7518765 B2 JP 7518765B2 JP 2020528027 A JP2020528027 A JP 2020528027A JP 2020528027 A JP2020528027 A JP 2020528027A JP 7518765 B2 JP7518765 B2 JP 7518765B2
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compound
pharmaceutical composition
deuterium
formula
disease
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JP2021504326A (ja
JP2021504326A5 (https=
Inventor
ドラー，ダリオ
エル． ブランメル，クリストファー
エフ． リウ，ジュリー
ディー． タン，ロジャー
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コンサート ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020528027A 2017-11-22 2018-11-21 Ｄ－セリンの重水素化類似体およびその使用 Active JP7518765B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023091296A JP7733058B2 (ja) 2017-11-22 2023-06-02 Ｄ－セリンの重水素化類似体およびその使用
JP2025106389A JP2025138735A (ja) 2017-11-22 2025-06-24 Ｄ－セリンの重水素化類似体およびその使用

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762590109P 2017-11-22 2017-11-22
US62/590,109 2017-11-22
US201862636081P 2018-02-27 2018-02-27
US62/636,081 2018-02-27
US201862636427P 2018-02-28 2018-02-28
US62/636,427 2018-02-28
US201862755157P 2018-11-02 2018-11-02
US62/755,157 2018-11-02
PCT/US2018/062263 WO2019104179A1 (en) 2017-11-22 2018-11-21 Deuterated analogs of d-serine and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023091296A Division JP7733058B2 (ja) 2017-11-22 2023-06-02 Ｄ－セリンの重水素化類似体およびその使用

Publications (3)

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JP2021504326A JP2021504326A (ja) 2021-02-15
JP2021504326A5 JP2021504326A5 (https=) 2021-12-23
JP7518765B2 true JP7518765B2 (ja) 2024-07-18

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JP2020528027A Active JP7518765B2 (ja) 2017-11-22 2018-11-21 Ｄ－セリンの重水素化類似体およびその使用
JP2023091296A Active JP7733058B2 (ja) 2017-11-22 2023-06-02 Ｄ－セリンの重水素化類似体およびその使用
JP2025106389A Pending JP2025138735A (ja) 2017-11-22 2025-06-24 Ｄ－セリンの重水素化類似体およびその使用

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JP2023091296A Active JP7733058B2 (ja) 2017-11-22 2023-06-02 Ｄ－セリンの重水素化類似体およびその使用
JP2025106389A Pending JP2025138735A (ja) 2017-11-22 2025-06-24 Ｄ－セリンの重水素化類似体およびその使用

Country Status (13)

Country Link
US (4) US20200368193A1 (https=)
EP (2) EP4560024A3 (https=)
JP (3) JP7518765B2 (https=)
KR (1) KR102916897B1 (https=)
CN (1) CN111491629A (https=)
AU (2) AU2018371784B2 (https=)
BR (1) BR112020010156A2 (https=)
CA (1) CA3082834A1 (https=)
IL (2) IL274585B2 (https=)
MX (1) MX2020005336A (https=)
PL (1) PL3713557T3 (https=)
TW (1) TWI886093B (https=)
WO (1) WO2019104179A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023123476A (ja) * 2017-11-22 2023-09-05 コンサート ファーマシューティカルズ インコーポレイテッド Ｄ－セリンの重水素化類似体およびその使用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2738873C2 (ru) * 2018-12-29 2020-12-17 Общество С Ограниченной Ответственностью "Сольвекс" (Ооо "Сольвекс") Препарат для магнитно-резонансной томографии, содержащий дейтерированный саркозин, и способ диагностики с использованием этого препарата
WO2020206367A1 (en) * 2019-04-03 2020-10-08 Concert Pharmaceuticals, Inc. Processes for the preparation of deuterated d-serine
WO2020243638A1 (en) * 2019-05-30 2020-12-03 Concert Pharmaceuticals, Inc. Methods of treatment with deuterated analogs of d-serine
WO2021127572A1 (en) * 2019-12-19 2021-06-24 Intra-Cellular Therapies, Inc. Methods of schizophrenia treatment
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002511409A (ja) 1998-04-14 2002-04-16 ザ ジュネラル ホスピタル コーポレーション 神経精神疾患の治療法
US20140187597A1 (en) 2003-02-06 2014-07-03 Sarah Herzog Memorial Hospital Ezrath Nashim Association Pharmaceutical compositions for the treatment of movement disorders
US20170326137A1 (en) 2013-05-28 2017-11-16 Sarah Herzog Memorial Hospital-Ezrath Nashim Autoimmune-Induced Glutamatergic Receptor Dysfunction Methods and Treatments

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582931A (en) 1984-12-24 1986-04-15 Merck & Co., Inc. Preparation of 2-Deutero-D-serine
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US6221335B1 (en) 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
PT871440E (pt) 1995-12-07 2006-07-31 Daniel C Javitt Tratamento de sintomas negativos e cognitivos de esquizofrenia com antagonistas da captacao de glicina
US6361957B1 (en) 1999-08-03 2002-03-26 Glytech, Inc. Assay for D-serine transport antagonist and use for treating psychosis
US5845286A (en) 1996-12-24 1998-12-01 Colizza; Vincent Date value reduction system
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6258605B1 (en) 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
PT1104760E (pt) 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
CN1255185C (zh) 2001-05-03 2006-05-10 弗·哈夫曼-拉罗切有限公司 无定形甲磺酸奈非那韦的药物剂型
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
MX2007003731A (es) 2004-09-29 2007-08-14 Johnson & Johnson Formas de dosis farmaceuticas de compuestos similares a rapamicina amorfos estables.
JP5266042B2 (ja) 2005-04-11 2013-08-21 エール ユニヴァーシティ 統合失調症前駆症の治療方法
EP1934201A1 (en) 2005-10-06 2008-06-25 Auspex Pharmaceuticals Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
US7750168B2 (en) 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
JO2630B1 (en) 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080103122A1 (en) 2006-09-05 2008-05-01 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
IL188681A0 (en) 2008-01-09 2008-12-29 Amino Acid Solutions Inc Pharmaceutical compositions and methods utilizing a d-amino acid
WO2012019106A2 (en) 2010-08-06 2012-02-09 Board Of Regents Of The University Of Nebraska Positive and negative modulators of nmda receptors
US9040581B1 (en) 2013-02-21 2015-05-26 The Florida State University Research Foundation, Inc. Methods of treatment using D-serine
WO2014205074A2 (en) 2013-06-18 2014-12-24 The Trustees Of Columbia University In The City Of New York Devices, compositions and methods for imaging with raman scattering
WO2015160470A2 (en) * 2014-03-20 2015-10-22 The Trustees Of Princeton University Nadph production by the 10-formyl-thf pathway, and its use in the diagnosis and treatment of disease
GB201521903D0 (en) 2015-12-11 2016-01-27 Electrophoretics Ltd Isorbaric mass labels
WO2017210097A1 (en) 2016-06-02 2017-12-07 Metabolon, Inc. Mass spectrometry method for detection and quantitation of metabolites
JP7518765B2 (ja) * 2017-11-22 2024-07-18 コンサート ファーマシューティカルズ インコーポレイテッド Ｄ－セリンの重水素化類似体およびその使用
WO2020243650A1 (en) 2019-05-29 2020-12-03 Concert Pharmaceuticals, Inc. Deuterated analogs of d-serine and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002511409A (ja) 1998-04-14 2002-04-16 ザ ジュネラル ホスピタル コーポレーション 神経精神疾患の治療法
US20140187597A1 (en) 2003-02-06 2014-07-03 Sarah Herzog Memorial Hospital Ezrath Nashim Association Pharmaceutical compositions for the treatment of movement disorders
US20170326137A1 (en) 2013-05-28 2017-11-16 Sarah Herzog Memorial Hospital-Ezrath Nashim Autoimmune-Induced Glutamatergic Receptor Dysfunction Methods and Treatments

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Advances in Drug Research，1985年，Vol.14，p.1-40
Analytical Biochemistry，2013年，Vol.432，No.2，p.124-130
MEDCHEM NEWS，2014年，No.2，p.8-22
Schizophrenia Research，2010年，Vol.121，No.1-3，p.125-130
The FEBS Journal，2012年，Vol.279，No.4，p.612-624

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023123476A (ja) * 2017-11-22 2023-09-05 コンサート ファーマシューティカルズ インコーポレイテッド Ｄ－セリンの重水素化類似体およびその使用
JP7733058B2 (ja) 2017-11-22 2025-09-02 コンサート ファーマシューティカルズ インコーポレイテッド Ｄ－セリンの重水素化類似体およびその使用

Also Published As

Publication number Publication date
WO2019104179A1 (en) 2019-05-31
MX2020005336A (es) 2020-08-13
JP2023123476A (ja) 2023-09-05
BR112020010156A2 (pt) 2020-11-10
TW201924668A (zh) 2019-07-01
EP3713557B1 (en) 2025-03-12
TWI886093B (zh) 2025-06-11
KR102916897B1 (ko) 2026-01-26
KR20200103662A (ko) 2020-09-02
IL274585B1 (en) 2025-09-01
AU2025200345A1 (en) 2025-02-13
CA3082834A1 (en) 2019-05-31
JP2021504326A (ja) 2021-02-15
US20200368193A1 (en) 2020-11-26
US10668036B2 (en) 2020-06-02
US20250000830A1 (en) 2025-01-02
EP4560024A3 (en) 2025-08-20
IL274585A (en) 2020-06-30
IL274585B2 (en) 2026-01-01
EP4560024A2 (en) 2025-05-28
US20200390732A1 (en) 2020-12-17
AU2018371784A1 (en) 2020-05-28
CN111491629A (zh) 2020-08-04
PL3713557T3 (pl) 2025-09-22
IL322463A (en) 2025-09-01
WO2019104179A4 (en) 2019-08-01
JP7733058B2 (ja) 2025-09-02
JP2025138735A (ja) 2025-09-25
EP3713557A1 (en) 2020-09-30
AU2018371784B2 (en) 2024-10-17
US12029712B2 (en) 2024-07-09
US20190328692A1 (en) 2019-10-31

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