PL3713557T3 - Deuterowane analogi d-seryny i ich zastosowania - Google Patents
Deuterowane analogi d-seryny i ich zastosowaniaInfo
- Publication number
- PL3713557T3 PL3713557T3 PL18825828.9T PL18825828T PL3713557T3 PL 3713557 T3 PL3713557 T3 PL 3713557T3 PL 18825828 T PL18825828 T PL 18825828T PL 3713557 T3 PL3713557 T3 PL 3713557T3
- Authority
- PL
- Poland
- Prior art keywords
- deuterated
- applications
- analogues
- serine
- serine analogues
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762590109P | 2017-11-22 | 2017-11-22 | |
| US201862636081P | 2018-02-27 | 2018-02-27 | |
| US201862636427P | 2018-02-28 | 2018-02-28 | |
| US201862755157P | 2018-11-02 | 2018-11-02 | |
| PCT/US2018/062263 WO2019104179A1 (en) | 2017-11-22 | 2018-11-21 | Deuterated analogs of d-serine and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3713557T3 true PL3713557T3 (pl) | 2025-09-22 |
Family
ID=64755715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18825828.9T PL3713557T3 (pl) | 2017-11-22 | 2018-11-21 | Deuterowane analogi d-seryny i ich zastosowania |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20200368193A1 (pl) |
| EP (2) | EP4560024A3 (pl) |
| JP (3) | JP7518765B2 (pl) |
| KR (1) | KR20200103662A (pl) |
| CN (1) | CN111491629A (pl) |
| AU (2) | AU2018371784B2 (pl) |
| BR (1) | BR112020010156A2 (pl) |
| CA (1) | CA3082834A1 (pl) |
| IL (2) | IL322463A (pl) |
| MX (1) | MX2020005336A (pl) |
| PL (1) | PL3713557T3 (pl) |
| TW (1) | TWI886093B (pl) |
| WO (1) | WO2019104179A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL322463A (en) * | 2017-11-22 | 2025-09-01 | Sun Pharmaceutical Ind Inc | Deuterated d-serine analogs and their uses |
| RU2738873C2 (ru) * | 2018-12-29 | 2020-12-17 | Общество С Ограниченной Ответственностью "Сольвекс" (Ооо "Сольвекс") | Препарат для магнитно-резонансной томографии, содержащий дейтерированный саркозин, и способ диагностики с использованием этого препарата |
| US12065395B2 (en) | 2019-04-03 | 2024-08-20 | Sun Pharmaceutical Industries, Inc. | Processes for the preparation of deuterated D-serine |
| US20220218641A1 (en) * | 2019-05-30 | 2022-07-14 | Concert Pharmaceuticals, Inc. | Methods of treatment with deuterated analogs of d-serine |
| WO2021127572A1 (en) * | 2019-12-19 | 2021-06-24 | Intra-Cellular Therapies, Inc. | Methods of schizophrenia treatment |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582931A (en) * | 1984-12-24 | 1986-04-15 | Merck & Co., Inc. | Preparation of 2-Deutero-D-serine |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| AU707748B2 (en) | 1994-03-25 | 1999-07-22 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| ATE320804T1 (de) | 1995-12-07 | 2006-04-15 | Daniel C Javitt | Behandlung negativer und kognitiver symptome der schizophrenie mit antagonisten der glycinaufnahme |
| US6361957B1 (en) | 1999-08-03 | 2002-03-26 | Glytech, Inc. | Assay for D-serine transport antagonist and use for treating psychosis |
| US5845286A (en) | 1996-12-24 | 1998-12-01 | Colizza; Vincent | Date value reduction system |
| PT1073432E (pt) * | 1998-04-14 | 2007-10-22 | Gen Hospital Corp | Utilização da d-alanina ou da d-serina para o tratamento da esquizofrenia |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| US6258605B1 (en) | 1999-03-26 | 2001-07-10 | Neo Gen Screening, Inc. | Clinical method for the genetic screening of newborns using tandem mass spectrometry |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| ES2193921T3 (es) | 1999-12-03 | 2003-11-16 | Pfizer Prod Inc | Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos. |
| HRP20030873B1 (en) | 2001-05-03 | 2006-04-30 | F. Hoffmann - La Roche Ag | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| IL154318A (en) * | 2003-02-06 | 2010-05-31 | Sarah Herzog Memorial Hospital | Pharmaceutical compositions for the treatment of movement disorders |
| JP2008514706A (ja) | 2004-09-29 | 2008-05-08 | コーディス・コーポレイション | 安定非晶質ラパマイシン様化合物の薬学的投与形態 |
| CA2602626A1 (en) | 2005-04-11 | 2006-10-19 | Yale University | Method of treating schizophrenia prodrome |
| US7598273B2 (en) | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| EP2059241A1 (en) | 2006-09-05 | 2009-05-20 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| IL188681A0 (en) | 2008-01-09 | 2008-12-29 | Amino Acid Solutions Inc | Pharmaceutical compositions and methods utilizing a d-amino acid |
| WO2012019106A2 (en) | 2010-08-06 | 2012-02-09 | Board Of Regents Of The University Of Nebraska | Positive and negative modulators of nmda receptors |
| US9040581B1 (en) | 2013-02-21 | 2015-05-26 | The Florida State University Research Foundation, Inc. | Methods of treatment using D-serine |
| US9687460B2 (en) | 2013-05-28 | 2017-06-27 | Sarah Herzog Memorial Hospital-Ezrath Nashim | Autoimmune-induced glutamatergic receptor dysfunction methods and treatments |
| WO2014205074A2 (en) | 2013-06-18 | 2014-12-24 | The Trustees Of Columbia University In The City Of New York | Devices, compositions and methods for imaging with raman scattering |
| WO2015160470A2 (en) * | 2014-03-20 | 2015-10-22 | The Trustees Of Princeton University | Nadph production by the 10-formyl-thf pathway, and its use in the diagnosis and treatment of disease |
| GB201521903D0 (en) | 2015-12-11 | 2016-01-27 | Electrophoretics Ltd | Isorbaric mass labels |
| US11181530B2 (en) | 2016-06-02 | 2021-11-23 | Metabolon, Inc. | Mass spectrometry method for detection and quantitation of metabolites |
| IL322463A (en) | 2017-11-22 | 2025-09-01 | Sun Pharmaceutical Ind Inc | Deuterated d-serine analogs and their uses |
| US20220313640A1 (en) | 2019-05-29 | 2022-10-06 | Dario Doller | Deuterated analogs of d-serine and uses thereof |
-
2018
- 2018-11-21 IL IL322463A patent/IL322463A/en unknown
- 2018-11-21 EP EP25156008.2A patent/EP4560024A3/en active Pending
- 2018-11-21 IL IL274585A patent/IL274585B1/en unknown
- 2018-11-21 AU AU2018371784A patent/AU2018371784B2/en active Active
- 2018-11-21 WO PCT/US2018/062263 patent/WO2019104179A1/en not_active Ceased
- 2018-11-21 MX MX2020005336A patent/MX2020005336A/es unknown
- 2018-11-21 KR KR1020207017407A patent/KR20200103662A/ko active Pending
- 2018-11-21 BR BR112020010156-7A patent/BR112020010156A2/pt unknown
- 2018-11-21 CN CN201880081985.1A patent/CN111491629A/zh active Pending
- 2018-11-21 EP EP18825828.9A patent/EP3713557B1/en active Active
- 2018-11-21 US US16/766,194 patent/US20200368193A1/en not_active Abandoned
- 2018-11-21 JP JP2020528027A patent/JP7518765B2/ja active Active
- 2018-11-21 CA CA3082834A patent/CA3082834A1/en active Pending
- 2018-11-21 PL PL18825828.9T patent/PL3713557T3/pl unknown
- 2018-11-22 TW TW107141705A patent/TWI886093B/zh active
-
2019
- 2019-07-02 US US16/459,916 patent/US10668036B2/en active Active
-
2020
- 2020-05-27 US US16/884,652 patent/US12029712B2/en active Active
-
2023
- 2023-06-02 JP JP2023091296A patent/JP7733058B2/ja active Active
-
2024
- 2024-06-03 US US18/731,580 patent/US20250000830A1/en active Pending
-
2025
- 2025-01-17 AU AU2025200345A patent/AU2025200345A1/en active Pending
- 2025-06-24 JP JP2025106389A patent/JP2025138735A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4560024A3 (en) | 2025-08-20 |
| MX2020005336A (es) | 2020-08-13 |
| JP7733058B2 (ja) | 2025-09-02 |
| IL274585B1 (en) | 2025-09-01 |
| US20200368193A1 (en) | 2020-11-26 |
| US20250000830A1 (en) | 2025-01-02 |
| EP3713557B1 (en) | 2025-03-12 |
| KR20200103662A (ko) | 2020-09-02 |
| AU2025200345A1 (en) | 2025-02-13 |
| CA3082834A1 (en) | 2019-05-31 |
| US20200390732A1 (en) | 2020-12-17 |
| JP7518765B2 (ja) | 2024-07-18 |
| BR112020010156A2 (pt) | 2020-11-10 |
| US20190328692A1 (en) | 2019-10-31 |
| WO2019104179A1 (en) | 2019-05-31 |
| JP2023123476A (ja) | 2023-09-05 |
| US12029712B2 (en) | 2024-07-09 |
| AU2018371784A1 (en) | 2020-05-28 |
| TWI886093B (zh) | 2025-06-11 |
| CN111491629A (zh) | 2020-08-04 |
| WO2019104179A4 (en) | 2019-08-01 |
| US10668036B2 (en) | 2020-06-02 |
| EP4560024A2 (en) | 2025-05-28 |
| JP2021504326A (ja) | 2021-02-15 |
| IL322463A (en) | 2025-09-01 |
| TW201924668A (zh) | 2019-07-01 |
| EP3713557A1 (en) | 2020-09-30 |
| AU2018371784B2 (en) | 2024-10-17 |
| JP2025138735A (ja) | 2025-09-25 |
| IL274585A (en) | 2020-06-30 |
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