JP7495138B2 - ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 - Google Patents

ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 Download PDF

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JP7495138B2
JP7495138B2 JP2021510959A JP2021510959A JP7495138B2 JP 7495138 B2 JP7495138 B2 JP 7495138B2 JP 2021510959 A JP2021510959 A JP 2021510959A JP 2021510959 A JP2021510959 A JP 2021510959A JP 7495138 B2 JP7495138 B2 JP 7495138B2
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substituted
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myocardial infarction
composition
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JP2021534221A (ja
JP2021534221A5 (enExample
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バート ダブリュー． オマリー，
デイビッド マイケル ロナルド，
ヨンチェン ソン，
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Baylor College of Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
JP2021510959A 2018-08-29 2019-08-29 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 Active JP7495138B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024080082A JP7777263B2 (ja) 2018-08-29 2024-05-16 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法
JP2025153392A JP2025183370A (ja) 2018-08-29 2025-09-16 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法

Applications Claiming Priority (5)

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US201862724281P 2018-08-29 2018-08-29
US62/724,281 2018-08-29
US201962825358P 2019-03-28 2019-03-28
US62/825,358 2019-03-28
PCT/US2019/048703 WO2020047186A1 (en) 2018-08-29 2019-08-29 Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

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JP2021534221A JP2021534221A (ja) 2021-12-09
JP2021534221A5 JP2021534221A5 (enExample) 2022-09-02
JP7495138B2 true JP7495138B2 (ja) 2024-06-04

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JP2021510959A Active JP7495138B2 (ja) 2018-08-29 2019-08-29 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法
JP2024080082A Active JP7777263B2 (ja) 2018-08-29 2024-05-16 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法
JP2025153392A Pending JP2025183370A (ja) 2018-08-29 2025-09-16 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法

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JP2025153392A Pending JP2025183370A (ja) 2018-08-29 2025-09-16 ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法

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US (4) US10875841B2 (enExample)
EP (1) EP3843843A1 (enExample)
JP (3) JP7495138B2 (enExample)
CN (2) CN120136844A (enExample)
AU (2) AU2019333119B2 (enExample)
CA (1) CA3110839A1 (enExample)
WO (1) WO2020047186A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3110839A1 (en) * 2018-08-29 2020-03-05 Baylor College Of Medicine Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents
AU2021372270A1 (en) 2020-10-28 2023-06-22 Baylor College Of Medicine Targeting of src-3 in immune cells as an immunomodulatory therapeutic for the treatment of cancer
WO2025240566A1 (en) * 2024-05-17 2025-11-20 Baylor College Of Medicine Small molecule steroid receptor coactivator stimulators for use in repairing tissue

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CN103181922A (zh) 2013-04-02 2013-07-03 温州医学院 一类含哌啶酮的单羰基姜黄素类化合物在制备抗炎药物中的应用
WO2016109470A1 (en) 2014-12-30 2016-07-07 Baylor College Of Medicine Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer
CN106083704A (zh) 2016-06-06 2016-11-09 福建医科大学 3,5‑(E)‑ 二芳亚甲基‑N‑环丙基哌啶‑4‑酮类化合物作为Hsp90抑制剂的应用
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CN102153508A (zh) 2010-10-08 2011-08-17 福建医科大学 3,5-(e)-二亚苄基-n-环丙基哌啶-4-酮及其在制备治疗抗肿瘤药物中的应用
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JP2021534221A (ja) 2021-12-09
US20200071300A1 (en) 2020-03-05
JP2024102352A (ja) 2024-07-30
CN112955217A (zh) 2021-06-11
US20230357200A1 (en) 2023-11-09
WO2020047186A1 (en) 2020-03-05
US20250282755A1 (en) 2025-09-11
US20210115017A1 (en) 2021-04-22
CN112955217B (zh) 2025-04-08
JP7777263B2 (ja) 2025-11-28
AU2025226726A1 (en) 2025-09-25
CA3110839A1 (en) 2020-03-05
CN120136844A (zh) 2025-06-13
AU2019333119B2 (en) 2025-06-05
AU2019333119A1 (en) 2021-03-18
JP2025183370A (ja) 2025-12-16
US12338229B2 (en) 2025-06-24
US11708350B2 (en) 2023-07-25
US10875841B2 (en) 2020-12-29
EP3843843A1 (en) 2021-07-07

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