JP7481263B2 - チオフェン誘導体の結晶形 - Google Patents

チオフェン誘導体の結晶形 Download PDF

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JP7481263B2
JP7481263B2 JP2020561687A JP2020561687A JP7481263B2 JP 7481263 B2 JP7481263 B2 JP 7481263B2 JP 2020561687 A JP2020561687 A JP 2020561687A JP 2020561687 A JP2020561687 A JP 2020561687A JP 7481263 B2 JP7481263 B2 JP 7481263B2
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crystalline form
pyrrol
thieno
dihydro
dioxo
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JP2021523891A (ja
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張冬雷
王立宇
李幸▲ウェン▼
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Tianjin Hemay Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
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  • Dermatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
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JP2020561687A 2018-05-02 2019-04-30 チオフェン誘導体の結晶形 Active JP7481263B2 (ja)

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JP2023204100A JP2024026251A (ja) 2018-05-02 2023-12-01 チオフェン誘導体の結晶形

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CN201810407741 2018-05-02
CN201810407741.X 2018-05-02
PCT/CN2019/085360 WO2019210869A1 (zh) 2018-05-02 2019-04-30 噻吩衍生物的晶型

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JP2020561687A Active JP7481263B2 (ja) 2018-05-02 2019-04-30 チオフェン誘導体の結晶形
JP2021510510A Pending JP2021523935A (ja) 2018-05-02 2019-04-30 チオフェン誘導体の固体形態
JP2021510509A Active JP7542523B2 (ja) 2018-05-02 2019-04-30 チオフェン誘導体の結晶形
JP2020561683A Active JP7477459B2 (ja) 2018-05-02 2019-04-30 チオフェン誘導体の結晶形
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JP2021510509A Active JP7542523B2 (ja) 2018-05-02 2019-04-30 チオフェン誘導体の結晶形
JP2020561683A Active JP7477459B2 (ja) 2018-05-02 2019-04-30 チオフェン誘導体の結晶形
JP2023204100A Withdrawn JP2024026251A (ja) 2018-05-02 2023-12-01 チオフェン誘導体の結晶形

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Publication number Priority date Publication date Assignee Title
PL3789389T3 (pl) * 2018-05-02 2026-03-16 Tianjin Hemay Pharmaceutical Co., Ltd. Postać krystaliczna (s)-n-[5-[1-(3-etoksy-4-metoksyfenylo)-2-(metylosulfonylo)etylo]-4,6-diokso-5,6-dihydro-4h-tieno[3,4-c]pirol-1-ilo]acetamidu
WO2025103428A1 (zh) * 2023-11-14 2025-05-22 赣州和美药业股份有限公司 中重度斑块型银屑病的治疗

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JP2012526731A (ja) 2009-05-14 2012-11-01 天津和美生物技術有限公司 チオフェン誘導体
JP2020523295A (ja) 2017-06-13 2020-08-06 バイオセリックス, インコーポレイテッド 二環式化合物および使用方法
JP2021522348A (ja) 2018-05-02 2021-08-30 ティエンジン・フーメイ・ファーマシューティカル・カンパニー・リミテッドTianjin Hemay Pharmaceutical Co., Ltd. チオフェン誘導体の結晶形

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JP2021522348A (ja) 2018-05-02 2021-08-30 ティエンジン・フーメイ・ファーマシューティカル・カンパニー・リミテッドTianjin Hemay Pharmaceutical Co., Ltd. チオフェン誘導体の結晶形
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JP2024026251A (ja) 2024-02-28
FI3789389T3 (fi) 2025-11-19
JP2021523935A (ja) 2021-09-09
JP2021523891A (ja) 2021-09-09
KR20210025001A (ko) 2021-03-08
EP3789388B1 (en) 2024-01-24
JP7542523B2 (ja) 2024-08-30
AU2019262282A1 (en) 2020-11-12
EP3800190A4 (en) 2022-01-26
KR20210022557A (ko) 2021-03-03
CA3098927C (en) 2023-10-03
PT3789389T (pt) 2025-12-17
CA3099072A1 (en) 2019-11-07
KR102701245B1 (ko) 2024-08-30
EP3789387B1 (en) 2024-02-28
WO2019210864A1 (zh) 2019-11-07
ES3047059T3 (en) 2025-12-03
JP2021523890A (ja) 2021-09-09
BR112020022190A2 (pt) 2021-02-02
EP3789389A4 (en) 2022-01-26
EP3800190A1 (en) 2021-04-07
CN110437251B (zh) 2023-07-21
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PL3789389T3 (pl) 2026-03-16
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CN110437251A (zh) 2019-11-12
AU2019262282B2 (en) 2022-04-28
AU2019262284A1 (en) 2020-12-24
CA3098927A1 (en) 2019-11-07
KR102839924B1 (ko) 2025-07-29
EP3789387A1 (en) 2021-03-10
CN110437250A (zh) 2019-11-12
CA3213055A1 (en) 2019-11-07
CN110437249A (zh) 2019-11-12
KR102686835B1 (ko) 2024-07-22
BR112020022186A2 (pt) 2021-02-02
AU2019262286A1 (en) 2020-11-12

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