JP7476422B2 - Ｌｐａ発現を阻害するための組成物及び方法 - Google Patents

Ｌｐａ発現を阻害するための組成物及び方法 Download PDF

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JP7476422B2
JP7476422B2 JP2023507767A JP2023507767A JP7476422B2 JP 7476422 B2 JP7476422 B2 JP 7476422B2 JP 2023507767 A JP2023507767 A JP 2023507767A JP 2023507767 A JP2023507767 A JP 2023507767A JP 7476422 B2 JP7476422 B2 JP 7476422B2
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lpa
oligonucleotide
seq
nucleotides
antisense strand
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JP2023536974A5 (enExample
JP2023536974A (ja
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ボブ デール ブラウン
ヘンリク ティー ドゥデク
マーク エイブラムス
ウェン ハン
アントン トゥラノフ
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Dicerna Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2023507767A 2020-08-05 2021-08-05 Ｌｐａ発現を阻害するための組成物及び方法 Active JP7476422B2 (ja)

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JP2024034617A JP7805386B2 (ja) 2020-08-05 2024-03-07 Ｌｐａ発現を阻害するための組成物及び方法
JP2026003542A JP2026077639A (ja) 2020-08-05 2026-01-13 Ｌｐａ発現を阻害するための組成物及び方法

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US202063061676P 2020-08-05 2020-08-05
US63/061,676 2020-08-05
US202063074779P 2020-09-04 2020-09-04
US63/074,779 2020-09-04
PCT/US2021/071109 WO2022032288A1 (en) 2020-08-05 2021-08-05 Compositions and methods for inhibiting lpa expression

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US (3) US12435336B2 (enExample)
EP (1) EP4192954A1 (enExample)
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KR (2) KR20250077604A (enExample)
CN (1) CN116323943A (enExample)
AU (2) AU2021320550B2 (enExample)
BR (1) BR112023001957A2 (enExample)
CA (1) CA3185348A1 (enExample)
IL (1) IL300338A (enExample)
MX (1) MX2023001538A (enExample)
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KR20250077604A (ko) 2020-08-05 2025-05-30 다이서나 파마수이티컬, 인크. Lpa 발현을 저해하기 위한 조성물 및 방법
WO2023041079A1 (zh) * 2021-09-18 2023-03-23 上海金中锘美生物医药科技有限公司 Lpa抑制剂及其用途
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WO2024197065A2 (en) * 2023-03-20 2024-09-26 Verve Therapeutics, Inc. In vivo nickase-based editing of the lpa gene for treatment of cardiovascular disease
CN118685405A (zh) * 2023-06-20 2024-09-24 施能康医药科技(苏州)有限公司 靶向脂蛋白a的核酸及其用途
UY40897A (es) 2023-09-21 2025-03-31 Ionis Pharmaceuticals Inc Compuestos y métodos para inhibir lpa
WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
CN120344664A (zh) * 2023-10-27 2025-07-18 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途
CN120020252A (zh) * 2023-11-17 2025-05-20 纳肽得(青岛)生物医药有限公司 抑制LPA表达的siRNA及其用途
CN122514601A (zh) * 2023-11-29 2026-08-04 美国圣因生物股份有限公司 靶向Lp(a)的小干扰RNA及其用途
CN120098993A (zh) * 2023-12-05 2025-06-06 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
TW202546233A (zh) * 2024-02-05 2025-12-01 美商靖因藥業（上海）有限公司 用於抑制ｌｐ（ａ）或ａｐｏｃ３之表現的多核酸分子、醫藥組合物及其用途
WO2026026890A1 (zh) * 2024-07-31 2026-02-05 前沿生物药业(南京)股份有限公司 用于抑制LPA基因表达的siRNA及其修饰物与应用
WO2026057051A1 (zh) * 2024-09-14 2026-03-19 深圳信立泰药业股份有限公司 一种用于抑制细胞中LPA基因表达的RNAi剂、其制备方法及用途
WO2026092650A1 (zh) * 2024-11-01 2026-05-07 迈威(上海)生物科技股份有限公司 一种抑制LPA基因表达的RNAi制剂及其应用
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