CN116323943A - 用于抑制lpa表达的组合物和方法 - Google Patents

用于抑制lpa表达的组合物和方法 Download PDF

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CN116323943A
CN116323943A CN202180058046.7A CN202180058046A CN116323943A CN 116323943 A CN116323943 A CN 116323943A CN 202180058046 A CN202180058046 A CN 202180058046A CN 116323943 A CN116323943 A CN 116323943A
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seq
antisense strand
nucleotides
sense strand
nucleotide sequence
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B·D·布朗
H·T·杜德克
M·艾布拉姆斯
W·韩
A·图拉诺夫
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Dicerna Pharmaceuticals Inc
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CN202180058046.7A 2020-08-05 2021-08-05 用于抑制lpa表达的组合物和方法 Pending CN116323943A (zh)

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US202063061676P 2020-08-05 2020-08-05
US63/061676 2020-08-05
US202063074779P 2020-09-04 2020-09-04
US63/074779 2020-09-04
PCT/US2021/071109 WO2022032288A1 (en) 2020-08-05 2021-08-05 Compositions and methods for inhibiting lpa expression

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EP (1) EP4192954A1 (enExample)
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AU (2) AU2021320550B2 (enExample)
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WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
WO2025087442A1 (zh) * 2023-10-27 2025-05-01 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途
WO2025103457A1 (zh) * 2023-11-17 2025-05-22 纳肽得(青岛)生物医药有限公司 抑制LPA表达的siRNA及其用途
WO2025119212A1 (zh) * 2023-12-05 2025-06-12 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途

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KR20250130686A (ko) 2023-01-13 2025-09-02 일라이 릴리 앤드 캄파니 치료 올리고뉴클레오티드-함유 제약 조성물 및 그를 사용한 투여 요법
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
WO2025087442A1 (zh) * 2023-10-27 2025-05-01 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途
CN120344664A (zh) * 2023-10-27 2025-07-18 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途
WO2025103457A1 (zh) * 2023-11-17 2025-05-22 纳肽得(青岛)生物医药有限公司 抑制LPA表达的siRNA及其用途
WO2025119212A1 (zh) * 2023-12-05 2025-06-12 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途

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