JP7471479B2 - 閉塞性睡眠時無呼吸を治療する刺激 - Google Patents
閉塞性睡眠時無呼吸を治療する刺激 Download PDFInfo
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Description
個々の呼吸サイクル(例えば、654A)の吸気フェズ162の持続時間(I)よりかなり短いため、複数の異なる刺激期間は1つの吸気フェズ162に渡って発生する。したがって、この配置を利用すると、いくつかの刺激サイクルは1つの基準呼吸サイクルにおいて繰り返される。
呼吸サイクルの特徴から独立している(すなわち、呼吸サイクルの特徴に対して同期的でない)と思われる。むしろ、刺激プロトコル650の非同期の本質は、刺激期間652C-652Fが呼吸サイクル654Aの呼気フェズ170に渡って発生することを介して表現され、それは、同様な刺激サイクルは刺激期間が基準呼吸サイクルの異なる部分に対してどこに位置するかに関わらず繰り返されるからである。
Claims (20)
- 閉塞性睡眠時無呼吸を治療する装置であって、
埋め込み刺激電極を備え、
前記埋め込み刺激電極は、刺激パルスを受信し、一連の連続する刺激サイクルを含む第1刺激プロトコルに基づいて、上気道の呼吸の通り道に関連する筋肉へ刺激可能で上気道開存性の保持又は回復に関連した上気道開存性関連神経へ刺激し、各刺激サイクルが刺激期間と非刺激期間とを含み、前記第1刺激プロトコルにおいて、刺激期間のタイミングが患者の呼吸に対して非同期的であり、各刺激期間の持続時間が各非刺激期間の持続時間より長い、装置。 - 前記埋め込み刺激電極と通信可能であり、前記埋め込み刺激電極に前記刺激パルスを送信し、患者の身体の外部にある外部部品を含むパルス発生器をさらに含む、請求項1に記載の装置。
- 患者の呼吸に対して前記刺激の前記非同期的なタイミングは、前記第1刺激プロトコルの適用中において積極的に検出された呼吸に基づかないタイミングを含む、請求項1に記載の装置。
- 各刺激期間の持続時間が基準呼吸関連パラメータに基づくものであり、
前記基準呼吸関連パラメータは、基準呼吸サイクルの持続時間、または、前記基準呼吸サイクルの吸気フェズの持続時間を含む、
請求項1に記載の装置。 - 前記基準呼吸関連パラメータは基準呼吸サイクルの持続時間を含み、前記刺激サイクルの各刺激期間の持続時間は前記基準呼吸サイクルの吸気フェズの持続時間より長い、請求項4に記載の装置。
- 前記基準呼吸関連パラメータは安定な呼吸に基づくものである、請求項4に記載の装置。
- 前記基準呼吸関連パラメータは基準呼吸サイクルの持続時間を含み、対応する1つの刺激期間と対応する1つの非刺激期間との組み合わせは刺激サイクルを含み、前記刺激サイクルの持続時間は前記基準呼吸サイクルの持続時間より短い、請求項4に記載の装置。
- 前記基準呼吸関連パラメータは基準呼吸サイクルの持続時間を含み、前記各呼吸刺激サイクルの持続時間は基準呼吸サイクルの持続時間の30%より短い、請求項4に記載の装置。
- 対応する1つの刺激期間と対応する1つの非刺激期間は少なくとも1.5対1の比となる、請求項1に記載の装置。
- 対応する1つの刺激期間の持続時間は対応する1つの非刺激期間の持続時間の3倍を超える、請求項9に記載の装置。
- 対応する1つの刺激期間の持続時間は各刺激サイクルの持続時間の少なくとも80%を含む、請求項1に記載の装置。
- プロセッサと、
指令を記憶するための不揮発性コンピュータ可読媒体と、を含み、
前記指令は、前記第1刺激プロトコルを実現するためにプロセッサによって実行可能である請求項1に記載の装置。 - 前記基準呼吸関連パラメータは基準呼吸サイクルの持続時間を含み、前記第1刺激プロトコルは前記基準呼吸サイクルの持続時間において複数の刺激期間を送るためのものである、請求項4に記載の装置。
- 各非刺激期間の持続時間は少なくとも各刺激期間の持続時間の半分より短い、請求項13に記載の装置。
- 前記基準呼吸サイクルは、患者特有の履歴的な基準呼吸サイクル、および、複数の患者の基準呼吸サイクルの少なくとも1つを含む、請求項13に記載の装置。
- 前記刺激プロトコルは、前記基準呼吸サイクルの吸気フェズの持続時間において前記複数の刺激期間の少なくともいくつかを送るためのものである、請求項13に記載の装置。
- 前記各呼吸刺激サイクルの持続時間は少なくとも基準呼吸サイクルの持続時間の30%より短い、請求項13に記載の装置。
- 対応する1つの刺激期間と対応する1つの非刺激期間との組み合わせは刺激サイクルを含み、前記第1刺激プロトコルは前記基準呼吸サイクルの持続時間において1つ以上の刺激期間を送るためのものである、請求項13に記載の装置。
- 前記基準呼吸関連パラメータは基準呼吸サイクルの持続時間を含み、対応する1つの刺激期間と対応する1つの非刺激期間とは刺激サイクルを含み、前記刺激サイクルの持続時間は前記基準呼吸サイクルの持続時間より長い、請求項4に記載の装置。
- 対応する1つの刺激期間の持続時間は前記基準呼吸サイクルの持続時間より長い、請求項19に記載の装置。
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US201562135305P | 2015-03-19 | 2015-03-19 | |
US62/135,305 | 2015-03-19 | ||
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EP (2) | EP3271008A1 (ja) |
JP (3) | JP6759227B2 (ja) |
CN (2) | CN107864617B (ja) |
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JP2014525280A (ja) | 2011-08-11 | 2014-09-29 | インスパイア・メディカル・システムズ・インコーポレイテッド | 呼吸努力の検知結果に基づいて刺激プロトコルを選択するためのシステム |
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JP2020203110A (ja) | 2020-12-24 |
CN107864617B (zh) | 2021-08-20 |
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AU2020210249A1 (en) | 2020-08-20 |
AU2016233377A1 (en) | 2017-11-09 |
CN113908438A (zh) | 2022-01-11 |
CN107864617A (zh) | 2018-03-30 |
AU2021232791B2 (en) | 2023-04-20 |
WO2016149344A1 (en) | 2016-09-22 |
AU2016233377B2 (en) | 2020-04-30 |
JP2023058662A (ja) | 2023-04-25 |
EP3881892A1 (en) | 2021-09-22 |
JP6759227B2 (ja) | 2020-09-23 |
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AU2021232791A1 (en) | 2021-10-14 |
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