JP7471084B2 - 幹細胞由来星状細胞、作製方法および使用方法 - Google Patents

幹細胞由来星状細胞、作製方法および使用方法 Download PDF

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JP7471084B2
JP7471084B2 JP2019551936A JP2019551936A JP7471084B2 JP 7471084 B2 JP7471084 B2 JP 7471084B2 JP 2019551936 A JP2019551936 A JP 2019551936A JP 2019551936 A JP2019551936 A JP 2019551936A JP 7471084 B2 JP7471084 B2 JP 7471084B2
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JP2020513823A (ja
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ローレンツ ステューダー，
ジェイソン チエウ，
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メモリアル スローン ケタリング キャンサー センター
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JP2019551936A 2017-03-21 2018-03-21 幹細胞由来星状細胞、作製方法および使用方法 Active JP7471084B2 (ja)

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EP3787613B1 (en) 2018-04-30 2026-03-11 Cedars-Sinai Medical Center Pkc activation for use in treating early onset sporadic parkinson's disease
AU2020370288B2 (en) * 2019-10-22 2026-02-12 Cedars-Sinai Medical Center Cortical neural progenitor cells from iPSCs
EP4206320A4 (en) * 2020-08-21 2025-02-12 JSR Corporation METHOD FOR CULTIVATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS, CULTURE OF HUMAN INDUCED PLURIPOTENT STEM CELLS AND METHOD FOR THE PRODUCTION OF CEREBRAL ORGANOIDS
CN116406303B (zh) * 2020-09-04 2025-07-29 孔二艳 将gfap氨基酸位点作为神经退行性疾病治疗靶标的应用
EP4212615A4 (en) * 2020-09-10 2024-11-27 JSR Corporation METHOD FOR THE PRODUCTION OF ASTROCYTE-LIKE CELLS
CN111961650B (zh) * 2020-10-20 2023-06-13 士泽生物医药（苏州）有限公司 一种体外获得神经胶质细胞的方法及其应用
WO2022251254A1 (en) * 2021-05-24 2022-12-01 The Johns Hopkins University Pharmacological intervention of the arachidonic acid pathway to cure amyotrophic lateral sclerosis
CN116478923B (zh) * 2022-04-26 2024-01-02 浙江霍德生物工程有限公司 一种星形胶质细胞的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003533224A (ja) 2000-05-17 2003-11-11 ジェロン コーポレイション 神経前駆細胞の集団
JP2009513269A (ja) 2005-10-27 2009-04-02 アルフォース， ジャン−エリック ダブリュー． 無細胞血液産物をインキュベートすることによって生成される無細胞、生体吸収性の組織再生マトリックス
JP2016535248A (ja) 2013-10-01 2016-11-10 カディマステム リミテッド 薬物スクリーニング及び筋萎縮性側索硬化症（ａｌｓ）の処置における使用のための、ヒト多能性幹細胞からのアストロサイトの指向性分化
WO2017057523A1 (ja) 2015-09-29 2017-04-06 学校法人慶應義塾 アストロサイト様細胞及びその調製方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001654A (en) * 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
US20120207744A1 (en) * 2009-03-19 2012-08-16 Mendlein John D Reprogramming compositions and methods of using the same
US9453198B2 (en) * 2010-05-25 2016-09-27 Memorial Sloan Kettering Cancer Center Method of nociceptor differentiation of human embryonic stem cells and uses thereof
PT2773748T (pt) * 2011-11-04 2020-03-26 Memorial Sloan Kettering Cancer Center Neurónios dopaminérgicos (da) do mesencéfalo para enxerto
WO2016103269A1 (en) * 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003533224A (ja) 2000-05-17 2003-11-11 ジェロン コーポレイション 神経前駆細胞の集団
JP2009513269A (ja) 2005-10-27 2009-04-02 アルフォース， ジャン−エリック ダブリュー． 無細胞血液産物をインキュベートすることによって生成される無細胞、生体吸収性の組織再生マトリックス
JP2016535248A (ja) 2013-10-01 2016-11-10 カディマステム リミテッド 薬物スクリーニング及び筋萎縮性側索硬化症（ａｌｓ）の処置における使用のための、ヒト多能性幹細胞からのアストロサイトの指向性分化
WO2017057523A1 (ja) 2015-09-29 2017-04-06 学校法人慶應義塾 アストロサイト様細胞及びその調製方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Benjamin Deneen et al.，The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord，Neuron，2006年，Vol.52，pp.953-968
Ho, Chi Kent，Who Am I: Blurring the Lines of Cellular Identity，UCLA Electronic Theses and Dissertations [online]，2013年，インターネット<https://escholarship.org/uc/item/5k61n96j>［検索日2022年3月31日］
Peng Kang et al.，Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis，Neuron，2012年，Vol.74，pp.79-94

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JP2020513823A (ja) 2020-05-21
US20200024574A1 (en) 2020-01-23
AU2018239426A1 (en) 2019-10-03
EP3600360A4 (en) 2021-04-21
CA3057104A1 (en) 2018-09-27
WO2018175574A1 (en) 2018-09-27
JP2022180634A (ja) 2022-12-06
AU2024203389A1 (en) 2024-06-06

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