JP7465368B2 - 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体 - Google Patents

血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体 Download PDF

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JP7465368B2
JP7465368B2 JP2022562298A JP2022562298A JP7465368B2 JP 7465368 B2 JP7465368 B2 JP 7465368B2 JP 2022562298 A JP2022562298 A JP 2022562298A JP 2022562298 A JP2022562298 A JP 2022562298A JP 7465368 B2 JP7465368 B2 JP 7465368B2
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JP2023521200A (ja
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マティアス エクハルト
マリナ クリスティナ ヴィルヴァハー
ユルゲン プレストル
フェレンツ コンテス
レオ トーマス
クリストファー ジークフリート タウターマン
ディーター ヴィーデンマイアー
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2022562298A 2020-11-16 2021-11-12 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体 Active JP7465368B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024055696A JP7810743B2 (ja) 2020-11-16 2024-03-29 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20207719 2020-11-16
EP20207719.4 2020-11-16
PCT/EP2021/081459 WO2022101377A1 (en) 2020-11-16 2021-11-12 Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists

Related Child Applications (1)

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JP2024055696A Division JP7810743B2 (ja) 2020-11-16 2024-03-29 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体

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JP2023521200A JP2023521200A (ja) 2023-05-23
JP7465368B2 true JP7465368B2 (ja) 2024-04-10

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JP2022562298A Active JP7465368B2 (ja) 2020-11-16 2021-11-12 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体
JP2024055696A Active JP7810743B2 (ja) 2020-11-16 2024-03-29 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体

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US (2) US11766443B2 (https=)
EP (1) EP4244229A1 (https=)
JP (2) JP7465368B2 (https=)
KR (1) KR20230109692A (https=)
CN (2) CN116745300A (https=)
AR (1) AR124070A1 (https=)
AU (1) AU2021379248A1 (https=)
CA (1) CA3200710A1 (https=)
CL (2) CL2023001361A1 (https=)
CO (1) CO2023005894A2 (https=)
CR (1) CR20230211A (https=)
DO (1) DOP2023000090A (https=)
EC (1) ECSP23036210A (https=)
IL (1) IL302769A (https=)
JO (1) JOP20230107A1 (https=)
MX (1) MX2023005678A (https=)
PE (1) PE20231855A1 (https=)
SA (1) SA523440809B1 (https=)
WO (1) WO2022101377A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119842821A (zh) * 2025-01-06 2025-04-18 华中科技大学 稳定表达血小板活化因子受体的细胞株、构建方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502392A1 (de) 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
IE870123L (en) * 1986-01-21 1987-07-21 Boehringer Ingelheim Int Thieno-1,4-diazepines
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
DE3909012A1 (de) 1989-03-18 1990-09-20 Boehringer Ingelheim Kg Verbessertes verfahren zur herstellung von enantiomerenreinen hetrazepinen
DE4010528A1 (de) 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
DE4132763A1 (de) 1991-10-02 1993-04-08 Boehringer Ingelheim Kg Verbessertes verfahren zur herstellung von enantiomerenreinen saeureamiden hetrazepinoider struktur
FR2779652B1 (fr) 1998-06-15 2001-06-08 Sod Conseils Rech Applic Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
US20050032713A1 (en) * 2002-03-27 2005-02-10 Wurtman Richard J. Platelet-activating factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents
CA2670031A1 (en) 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CID 147780900，DATABASE pubchem [online]，2020年08月20日

Also Published As

Publication number Publication date
CN117624188A (zh) 2024-03-01
CR20230211A (es) 2023-07-13
CN116745300A (zh) 2023-09-12
US20220160725A1 (en) 2022-05-26
WO2022101377A1 (en) 2022-05-19
US20230355638A1 (en) 2023-11-09
CO2023005894A2 (es) 2023-05-29
ECSP23036210A (es) 2023-06-30
AR124070A1 (es) 2023-02-08
JP2024099528A (ja) 2024-07-25
KR20230109692A (ko) 2023-07-20
TW202237620A (zh) 2022-10-01
MX2023005678A (es) 2023-05-26
US11766443B2 (en) 2023-09-26
JP7810743B2 (ja) 2026-02-03
CA3200710A1 (en) 2022-05-19
AU2021379248A9 (en) 2024-10-10
CL2024000317A1 (es) 2024-07-12
DOP2023000090A (es) 2023-06-15
JOP20230107A1 (ar) 2023-05-16
AU2021379248A1 (en) 2023-06-22
IL302769A (en) 2023-07-01
CL2023001361A1 (es) 2023-11-03
SA523440809B1 (ar) 2024-10-08
JP2023521200A (ja) 2023-05-23
PE20231855A1 (es) 2023-11-21
EP4244229A1 (en) 2023-09-20

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