JP7462950B2 - ガンマポリグルタミン酸化メトトレキセートおよびその使用 - Google Patents

ガンマポリグルタミン酸化メトトレキセートおよびその使用 Download PDF

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JP7462950B2
JP7462950B2 JP2020543388A JP2020543388A JP7462950B2 JP 7462950 B2 JP7462950 B2 JP 7462950B2 JP 2020543388 A JP2020543388 A JP 2020543388A JP 2020543388 A JP2020543388 A JP 2020543388A JP 7462950 B2 JP7462950 B2 JP 7462950B2
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gamma
methotrexate
γpmtx
cancer
liposome
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JP2021514357A5 (enExample
JP2021514357A (ja
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ニイキザ，クレト
モヨ，ヴィクター，マンドラ
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LEAF Holdings Group LLC
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LEAF Holdings Group LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Mycology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020543388A 2018-02-14 2019-02-07 ガンマポリグルタミン酸化メトトレキセートおよびその使用 Active JP7462950B2 (ja)

Priority Applications (2)

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JP2024043740A JP7679113B2 (ja) 2018-02-14 2024-03-19 ガンマポリグルタミン酸化メトトレキセートおよびその使用
JP2025073080A JP2025118708A (ja) 2018-02-14 2025-04-25 ガンマポリグルタミン酸化メトトレキセートおよびその使用

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Application Number Priority Date Filing Date Title
US201862630713P 2018-02-14 2018-02-14
US62/630,713 2018-02-14
US201862662372P 2018-04-25 2018-04-25
US62/662,372 2018-04-25
US201862702774P 2018-07-24 2018-07-24
US62/702,774 2018-07-24
US201862764945P 2018-08-17 2018-08-17
US62/764,945 2018-08-17
PCT/US2019/016960 WO2019160733A1 (en) 2018-02-14 2019-02-07 Gamma polyglutamated methotrexate and uses thereof

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JP2024043740A Active JP7679113B2 (ja) 2018-02-14 2024-03-19 ガンマポリグルタミン酸化メトトレキセートおよびその使用
JP2025073080A Pending JP2025118708A (ja) 2018-02-14 2025-04-25 ガンマポリグルタミン酸化メトトレキセートおよびその使用

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EP (1) EP3752155A4 (enExample)
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CN (1) CN111936145A (enExample)
CA (1) CA3090989A1 (enExample)
WO (1) WO2019160733A1 (enExample)

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CN121177507A (zh) 2016-08-12 2025-12-23 L.E.A.F.控股集团公司 α和γ-D聚谷氨酸化抗叶酸剂及其用途
WO2018031968A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
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