JP7448219B2 - Ａｄａｍ１０の生物学的活性を阻害するための方法および組成物 - Google Patents

Ａｄａｍ１０の生物学的活性を阻害するための方法および組成物 Download PDF

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JP7448219B2
JP7448219B2 JP2020520057A JP2020520057A JP7448219B2 JP 7448219 B2 JP7448219 B2 JP 7448219B2 JP 2020520057 A JP2020520057 A JP 2020520057A JP 2020520057 A JP2020520057 A JP 2020520057A JP 7448219 B2 JP7448219 B2 JP 7448219B2
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amino acid
adam10
seq
regulatory peptide
positions
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JP2021500321A (ja
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エル モス マルシア
ラスムッセン ロバート
プリンス クリス
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VERRA THERAPEUTICS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24081—ADAM10 endopeptidase (3.4.24.81)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2020520057A 2017-10-02 2018-10-02 Ａｄａｍ１０の生物学的活性を阻害するための方法および組成物 Active JP7448219B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023187803A JP2024012470A (ja) 2017-10-02 2023-11-01 Ａｄａｍ１０の生物学的活性を阻害するための方法および組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762566580P 2017-10-02 2017-10-02
US62/566,580 2017-10-02
US201762589842P 2017-11-22 2017-11-22
US62/589,842 2017-11-22
PCT/US2018/053938 WO2019070685A1 (en) 2017-10-02 2018-10-02 METHODS AND COMPOSITIONS FOR INHIBITING BIOLOGICAL ACTIVITIES OF ADAM10

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JP2023187803A Division JP2024012470A (ja) 2017-10-02 2023-11-01 Ａｄａｍ１０の生物学的活性を阻害するための方法および組成物

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JP2021500321A JP2021500321A (ja) 2021-01-07
JP7448219B2 true JP7448219B2 (ja) 2024-03-12

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JP2023187803A Pending JP2024012470A (ja) 2017-10-02 2023-11-01 Ａｄａｍ１０の生物学的活性を阻害するための方法および組成物

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US (3) US20190345473A1 (enExample)
EP (1) EP3691671A4 (enExample)
JP (2) JP7448219B2 (enExample)
AU (1) AU2018345601B2 (enExample)
CA (1) CA3077694A1 (enExample)
IL (1) IL273725A (enExample)
MX (1) MX2020004218A (enExample)
WO (1) WO2019070685A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12247232B2 (en) 2018-01-31 2025-03-11 Verra Therapeutics, Inc. Methods and compositions for inhibiting ADAM 9 biological activities
WO2020227714A1 (en) * 2019-05-09 2020-11-12 Verra Therapeutics, Llc Methods and compositions for inhibiting adam8 biological activities
US20250177333A1 (en) * 2022-03-08 2025-06-05 Nova Southeastern University Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012064865A1 (en) 2010-11-09 2012-05-18 The University Of Chicago Role of adam10 and its relevance to disease and therapeutics
US20130059788A1 (en) 2006-08-28 2013-03-07 Duke University Prodomain modulators of adam 10

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270625A1 (en) 2002-09-11 2004-04-30 Justus-Liebig-Universität Giessen Inhibition or activation of adam9 and adam15 for treatment of vascularization-related disease and wound healing
CA2525574C (en) * 2003-05-15 2015-06-30 Trustees Of Tufts College Stable analogs of peptide and polypeptide therapeutics
KR101317358B1 (ko) 2005-02-02 2013-10-15 레이븐 바이오테크놀로지스, 인코퍼레이티드 Ａｄａｍ-9 조절자
CA2604883A1 (en) 2005-04-07 2006-10-19 Albert Lai Adam10 in cancer diagnosis, detection and treatment
US20090285840A1 (en) 2008-04-29 2009-11-19 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Methods for treating pathological neovascularization
US8079782B1 (en) 2008-05-16 2011-12-20 Hilfiker William K Semi-extensible steel soil reinforcements for mechanically stabilized embankments
WO2012088105A2 (en) * 2010-12-20 2012-06-28 Biozyme Inc. Methods and compositions for predicting disease status in cancer
WO2015117199A1 (en) 2014-02-04 2015-08-13 Monash University Anti-metalloprotease antibody for diagnosis and treatment of cancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130059788A1 (en) 2006-08-28 2013-03-07 Duke University Prodomain modulators of adam 10
WO2012064865A1 (en) 2010-11-09 2012-05-18 The University Of Chicago Role of adam10 and its relevance to disease and therapeutics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Furin is an endogenous regulator of α-secretase associated APP processing，Biochemical and Biophysical Research Communications，2006年，Vol. 349，p. 654-659
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10，Cellular and Molecular Life Sciences，2013年，Vol. 70，p. 309-333

Also Published As

Publication number Publication date
US20190345473A1 (en) 2019-11-14
US12297469B2 (en) 2025-05-13
MX2020004218A (es) 2020-11-11
US20230203468A1 (en) 2023-06-29
EP3691671A4 (en) 2022-01-19
JP2024012470A (ja) 2024-01-30
AU2018345601A1 (en) 2020-05-21
IL273725A (en) 2020-05-31
AU2018345601B2 (en) 2025-05-15
CA3077694A1 (en) 2019-04-11
WO2019070685A1 (en) 2019-04-11
US20250207119A1 (en) 2025-06-26
JP2021500321A (ja) 2021-01-07
EP3691671A1 (en) 2020-08-12

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