CA3077694A1 - Methods and compositions for inhibiting adam10 biological activities - Google Patents
Methods and compositions for inhibiting adam10 biological activities Download PDFInfo
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- CA3077694A1 CA3077694A1 CA3077694A CA3077694A CA3077694A1 CA 3077694 A1 CA3077694 A1 CA 3077694A1 CA 3077694 A CA3077694 A CA 3077694A CA 3077694 A CA3077694 A CA 3077694A CA 3077694 A1 CA3077694 A1 CA 3077694A1
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- amino acid
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- adam10
- modulating peptide
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
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- A61K38/46—Hydrolases (3)
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
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- A—HUMAN NECESSITIES
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566580P | 2017-10-02 | 2017-10-02 | |
| US62/566,580 | 2017-10-02 | ||
| US201762589842P | 2017-11-22 | 2017-11-22 | |
| US62/589,842 | 2017-11-22 | ||
| PCT/US2018/053938 WO2019070685A1 (en) | 2017-10-02 | 2018-10-02 | METHODS AND COMPOSITIONS FOR INHIBITING BIOLOGICAL ACTIVITIES OF ADAM10 |
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|---|---|
| CA3077694A1 true CA3077694A1 (en) | 2019-04-11 |
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| US12247232B2 (en) | 2018-01-31 | 2025-03-11 | Verra Therapeutics, Inc. | Methods and compositions for inhibiting ADAM 9 biological activities |
| WO2020227714A1 (en) * | 2019-05-09 | 2020-11-12 | Verra Therapeutics, Llc | Methods and compositions for inhibiting adam8 biological activities |
| US20250177333A1 (en) * | 2022-03-08 | 2025-06-05 | Nova Southeastern University | Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10) |
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| AU2003270625A1 (en) | 2002-09-11 | 2004-04-30 | Justus-Liebig-Universität Giessen | Inhibition or activation of adam9 and adam15 for treatment of vascularization-related disease and wound healing |
| CA2525574C (en) * | 2003-05-15 | 2015-06-30 | Trustees Of Tufts College | Stable analogs of peptide and polypeptide therapeutics |
| KR101317358B1 (ko) | 2005-02-02 | 2013-10-15 | 레이븐 바이오테크놀로지스, 인코퍼레이티드 | Ａｄａｍ-9 조절자 |
| CA2604883A1 (en) | 2005-04-07 | 2006-10-19 | Albert Lai | Adam10 in cancer diagnosis, detection and treatment |
| US7638301B2 (en) * | 2006-08-28 | 2009-12-29 | Biozyme, Inc. | Prodomain modulators of ADAM 10 |
| US20090285840A1 (en) | 2008-04-29 | 2009-11-19 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Methods for treating pathological neovascularization |
| US8079782B1 (en) | 2008-05-16 | 2011-12-20 | Hilfiker William K | Semi-extensible steel soil reinforcements for mechanically stabilized embankments |
| EP2637679A4 (en) * | 2010-11-09 | 2015-09-23 | Univ Chicago | ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASES AND THERAPEUTICS |
| WO2012088105A2 (en) * | 2010-12-20 | 2012-06-28 | Biozyme Inc. | Methods and compositions for predicting disease status in cancer |
| WO2015117199A1 (en) | 2014-02-04 | 2015-08-13 | Monash University | Anti-metalloprotease antibody for diagnosis and treatment of cancers |
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| EP3691671A1 (en) | 2020-08-12 |
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