JP7442443B2 - 多重特異性抗体 - Google Patents
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- JP7442443B2 JP7442443B2 JP2020519761A JP2020519761A JP7442443B2 JP 7442443 B2 JP7442443 B2 JP 7442443B2 JP 2020519761 A JP2020519761 A JP 2020519761A JP 2020519761 A JP2020519761 A JP 2020519761A JP 7442443 B2 JP7442443 B2 JP 7442443B2
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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| EP18150465.5 | 2018-01-05 | ||
| EP18150465 | 2018-01-05 | ||
| EP18167093.6 | 2018-04-12 | ||
| EP18167093 | 2018-04-12 | ||
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| EP18180814.8 | 2018-06-29 | ||
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| US11459394B2 (en) | 2017-02-24 | 2022-10-04 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
| US11365240B2 (en) * | 2017-06-05 | 2022-06-21 | Numab Therapeutics AG | Anti-HSA antibodies |
| EP3694880A1 (en) * | 2017-10-10 | 2020-08-19 | Numab Therapeutics AG | Antibodies targeting cd137 and methods of use thereof |
| JP2021502810A (ja) * | 2017-11-13 | 2021-02-04 | クレッシェンド、バイオロジックス、リミテッドＣｒｅｓｃｅｎｄｏ Ｂｉｏｌｏｇｉｃｓ Ｌｉｍｉｔｅｄ | Ｃｄ１３７およびｐｓｍａに結合する分子 |
| TWI839395B (zh) * | 2018-10-09 | 2024-04-21 | 瑞士商Ｎｕｍａｂ治療公司 | 靶向cd137的抗體及其使用方法 |
| WO2021013142A1 (zh) * | 2019-07-22 | 2021-01-28 | 江苏恒瑞医药股份有限公司 | 抗4-1bb抗体、其抗原结合片段及双特异性抗体 |
| EP4041772A4 (en) | 2019-10-11 | 2024-04-24 | Nanjing Leads Biolabs Co., Ltd. | 4-1BB-BINDING ANTIBODIES AND USES THEREOF |
| EP3816185A1 (en) * | 2019-11-04 | 2021-05-05 | Numab Therapeutics AG | Multispecific antibody directed against pd-l1 and a tumor-associated antigen |
| KR20220107251A (ko) * | 2020-01-09 | 2022-08-02 | 에프. 호프만-라 로슈 아게 | 새로운 4-1bbl 삼량체-함유 항원 결합 분자 |
| EP4153316A1 (en) | 2020-05-19 | 2023-03-29 | Boehringer Ingelheim International GmbH | Binding molecules for the treatment of cancer |
| EP4157352A1 (en) * | 2020-05-29 | 2023-04-05 | Numab Therapeutics AG | Multispecific antibody |
| CN114195900B (zh) * | 2020-09-17 | 2024-02-23 | 普米斯生物技术(珠海)有限公司 | 一种抗4-1bb/pd-l1双特异性抗体及其用途 |
| EP3988568A1 (en) | 2020-10-21 | 2022-04-27 | Numab Therapeutics AG | Combination treatment |
| WO2022136693A1 (en) | 2020-12-23 | 2022-06-30 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
| WO2023001987A2 (en) | 2021-07-22 | 2023-01-26 | University Of Dundee | Therapeutic muteins |
| EP4273162A1 (en) | 2022-05-06 | 2023-11-08 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
| WO2023214047A1 (en) | 2022-05-06 | 2023-11-09 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
| WO2024240690A2 (en) | 2023-05-19 | 2024-11-28 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
| WO2025133391A1 (en) | 2023-12-22 | 2025-06-26 | Numab Therapeutics AG | Multispecific antibodies having specificity for cd47 and pdl1 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017123650A2 (en) | 2016-01-11 | 2017-07-20 | Inhibrx Lp | Multivalent and multispecific 41bb-binding fusion proteins |
| JP2020537520A (ja) | 2017-10-10 | 2020-12-24 | ヌマブ セラピューティクス アクチェンゲゼルシャフト | Ｃｄ１３７を標的とする抗体とその利用方法 |
| JP2021501569A (ja) | 2017-10-10 | 2021-01-21 | ヌマブ セラピューティックス アーゲー | Ｐｄｌ１を標的とする抗体及びそれを用いる方法 |
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| MX2020003562A (es) | 2020-10-01 |
| WO2019072868A1 (en) | 2019-04-18 |
| JP2021501744A (ja) | 2021-01-21 |
| MA50352A (fr) | 2020-08-19 |
| ZA202001294B (en) | 2024-08-28 |
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