JP7442443B2 - 多重特異性抗体 - Google Patents

多重特異性抗体 Download PDF

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JP7442443B2
JP7442443B2 JP2020519761A JP2020519761A JP7442443B2 JP 7442443 B2 JP7442443 B2 JP 7442443B2 JP 2020519761 A JP2020519761 A JP 2020519761A JP 2020519761 A JP2020519761 A JP 2020519761A JP 7442443 B2 JP7442443 B2 JP 7442443B2
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seq
sequences
pdl1
amino acid
sequence
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JP2021501744A5 (enExample
JP2021501744A (ja
Inventor
ウレッヒ ダービド
グンデ テア
マイアー ゼバスチャン
ブロック マティーアス
ヘス クリスティアン
シモナン アレクサンドル
バルムート シュテファン
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ヌマブ セラピューティクス アクチェンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020519761A 2017-10-10 2018-10-09 多重特異性抗体 Active JP7442443B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP17195779.8A EP3470426A1 (en) 2017-10-10 2017-10-10 Multispecific antibody
EP17195779.8 2017-10-10
EP18150465 2018-01-05
EP18150465.5 2018-01-05
EP18167093 2018-04-12
EP18167093.6 2018-04-12
EP18180814 2018-06-29
EP18180814.8 2018-06-29
PCT/EP2018/077509 WO2019072868A1 (en) 2017-10-10 2018-10-09 MULTISPECIFIC ANTIBODIES

Publications (3)

Publication Number Publication Date
JP2021501744A JP2021501744A (ja) 2021-01-21
JP2021501744A5 JP2021501744A5 (enExample) 2021-11-18
JP7442443B2 true JP7442443B2 (ja) 2024-03-04

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JP2020519761A Active JP7442443B2 (ja) 2017-10-10 2018-10-09 多重特異性抗体

Country Status (17)

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US (2) US12202911B2 (enExample)
EP (1) EP3694873A1 (enExample)
JP (1) JP7442443B2 (enExample)
KR (1) KR102907331B1 (enExample)
CN (1) CN111194323B (enExample)
AU (1) AU2018348429B2 (enExample)
BR (1) BR112020006999A2 (enExample)
CA (1) CA3075969A1 (enExample)
CL (2) CL2020000937A1 (enExample)
CO (1) CO2020003882A2 (enExample)
IL (1) IL273576B2 (enExample)
MA (1) MA50352A (enExample)
MX (1) MX2020003562A (enExample)
PE (1) PE20200849A1 (enExample)
SG (1) SG11202002982YA (enExample)
WO (1) WO2019072868A1 (enExample)
ZA (1) ZA202001294B (enExample)

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BR112019017628A2 (pt) 2017-02-24 2020-07-07 Macrogenics, Inc. molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição
CN110709418B (zh) * 2017-06-05 2023-09-26 努玛治疗有限公司 新型抗hsa抗体
CN111183159B (zh) * 2017-10-10 2024-09-03 努玛治疗有限公司 靶向cd137的抗体及其使用方法
CA3082297A1 (en) * 2017-11-13 2019-05-16 Crescendo Biologics Limited Molecules that bind to cd137 and psma
TWI839395B (zh) * 2018-10-09 2024-04-21 瑞士商Ｎｕｍａｂ治療公司 靶向cd137的抗體及其使用方法
WO2021013142A1 (zh) * 2019-07-22 2021-01-28 江苏恒瑞医药股份有限公司 抗4-1bb抗体、其抗原结合片段及双特异性抗体
JP7634001B2 (ja) 2019-10-11 2025-02-20 ナンチン リーズ バイオラブス カンパニー，リミティド ４－１ｂｂに結合する抗体およびその用途
EP3816185A1 (en) * 2019-11-04 2021-05-05 Numab Therapeutics AG Multispecific antibody directed against pd-l1 and a tumor-associated antigen
JP7675083B2 (ja) * 2020-01-09 2025-05-12 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 新規４－１ｂｂｌ三量体含有抗原結合分子
JP2023504675A (ja) 2020-05-19 2023-02-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ガンの処置のための結合分子
MX2022014768A (es) * 2020-05-29 2023-01-11 Numab Therapeutics AG Anticuerpo multiespecifico.
CN114195900B (zh) * 2020-09-17 2024-02-23 普米斯生物技术(珠海)有限公司 一种抗4-1bb/pd-l1双特异性抗体及其用途
EP3988568A1 (en) 2020-10-21 2022-04-27 Numab Therapeutics AG Combination treatment
WO2022136693A1 (en) 2020-12-23 2022-06-30 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
EP4373848A2 (en) 2021-07-22 2024-05-29 University of Dundee Therapeutic muteins
EP4273162A1 (en) 2022-05-06 2023-11-08 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
CN119487062A (zh) 2022-05-06 2025-02-18 努玛治疗有限公司 具有降低的免疫原性的抗体可变结构域和抗体
PE20260551A1 (es) 2023-05-19 2026-03-04 Numab Therapeutics AG Dominios variables de anticuerpos y anticuerpos con inmunogenicidad disminuida
IL328540A (en) 2023-12-22 2026-07-01 Numab Therapeutics AG Antibody binding complexes specific for LILRB2

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JP2021501569A (ja) 2017-10-10 2021-01-21 ヌマブ セラピューティックス アーゲー Ｐｄｌ１を標的とする抗体及びそれを用いる方法

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WO2017123650A2 (en) 2016-01-11 2017-07-20 Inhibrx Lp Multivalent and multispecific 41bb-binding fusion proteins
JP2020537520A (ja) 2017-10-10 2020-12-24 ヌマブ セラピューティクス アクチェンゲゼルシャフト Ｃｄ１３７を標的とする抗体とその利用方法
JP2021501569A (ja) 2017-10-10 2021-01-21 ヌマブ セラピューティックス アーゲー Ｐｄｌ１を標的とする抗体及びそれを用いる方法

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EP3694873A1 (en) 2020-08-19
IL273576A (en) 2020-05-31
AU2018348429A1 (en) 2020-03-12
MX2020003562A (es) 2020-10-01
SG11202002982YA (en) 2020-04-29
CL2021000028A1 (es) 2021-05-28
CA3075969A1 (en) 2019-04-18
KR20200063155A (ko) 2020-06-04
WO2019072868A1 (en) 2019-04-18
US20230192897A1 (en) 2023-06-22
US12202911B2 (en) 2025-01-21
CL2020000937A1 (es) 2020-09-25
US20260201070A1 (en) 2026-07-16
MA50352A (fr) 2020-08-19
JP2021501744A (ja) 2021-01-21
CN111194323B (zh) 2024-07-09
PE20200849A1 (es) 2020-08-20
AU2018348429B2 (en) 2025-08-28
CN111194323A (zh) 2020-05-22
KR102907331B1 (ko) 2025-12-31
CO2020003882A2 (es) 2020-05-29
BR112020006999A2 (pt) 2020-10-06
IL273576B1 (en) 2026-02-01
ZA202001294B (en) 2024-08-28
IL273576B2 (en) 2026-06-01

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