JP7434328B2 - シトルリン化されたヒストン２ａ及び／又は４に結合する抗体 - Google Patents

シトルリン化されたヒストン２ａ及び／又は４に結合する抗体 Download PDF

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JP7434328B2
JP7434328B2 JP2021534820A JP2021534820A JP7434328B2 JP 7434328 B2 JP7434328 B2 JP 7434328B2 JP 2021534820 A JP2021534820 A JP 2021534820A JP 2021534820 A JP2021534820 A JP 2021534820A JP 7434328 B2 JP7434328 B2 JP 7434328B2
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antibody
seq
binding fragment
amino acid
antibodies
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JP2021535211A5 (enExample
JP2021535211A (ja
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マリア ヘンドリック ラーツ、ジョセフ
ジェラルドゥス シルヴァノ シリヴィ、レナート
ロスマレン、ヨハネス ウィルヘルムス ジェラルドゥス ヴァン
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シトリル ビー．ヴィ．
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Priority claimed from GBGB1900983.6A external-priority patent/GB201900983D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2021534820A 2018-08-21 2019-08-20 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体 Active JP7434328B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024016700A JP7835788B2 (ja) 2018-08-21 2024-02-06 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1813597.0 2018-08-21
GBGB1813597.0A GB201813597D0 (en) 2018-08-21 2018-08-21 Antibody
GBGB1900983.6A GB201900983D0 (en) 2019-01-24 2019-01-24 Antibody
GB1900983.6 2019-01-24
PCT/EP2019/072302 WO2020038963A1 (en) 2018-08-21 2019-08-20 Antibodies binding to citrullinated histone 2a and/or 4

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JP2024016700A Division JP7835788B2 (ja) 2018-08-21 2024-02-06 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体

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JP2021535211A JP2021535211A (ja) 2021-12-16
JP2021535211A5 JP2021535211A5 (enExample) 2022-08-29
JP7434328B2 true JP7434328B2 (ja) 2024-02-20

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JP2021534820A Active JP7434328B2 (ja) 2018-08-21 2019-08-20 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体
JP2024016700A Active JP7835788B2 (ja) 2018-08-21 2024-02-06 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体

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US (4) US20210395350A1 (enExample)
EP (2) EP4659807A3 (enExample)
JP (2) JP7434328B2 (enExample)
KR (2) KR20250148711A (enExample)
CN (2) CN112930356B (enExample)
AU (3) AU2019326740B2 (enExample)
CA (1) CA3110013A1 (enExample)
DK (1) DK3841120T3 (enExample)
ES (1) ES3048210T3 (enExample)
FI (1) FI3841120T3 (enExample)
HR (1) HRP20251346T1 (enExample)
IL (2) IL322482A (enExample)
LT (1) LT3841120T (enExample)
MX (3) MX2025007881A (enExample)
PT (1) PT3841120T (enExample)
RS (1) RS67385B1 (enExample)
SG (1) SG11202101652PA (enExample)
SI (1) SI3841120T1 (enExample)
SM (1) SMT202500388T1 (enExample)
WO (1) WO2020038963A1 (enExample)
ZA (1) ZA202101051B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
US10940204B2 (en) 2015-07-31 2021-03-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
LT3841120T (lt) 2018-08-21 2025-11-10 Antikūnai, surišantys citrulinuotą histoną 2a ir (arba) 4
JP2022504139A (ja) 2018-10-05 2022-01-13 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムの除去のためのｈｍｇｂ１タンパク質誘導体
WO2021209465A1 (en) * 2020-04-14 2021-10-21 Universiteit Maastricht Peptide for the treatment of net-associated diseases
US20230272054A1 (en) * 2020-07-07 2023-08-31 Research Institute At Nationwide Children's Hospital Combination therapies for the treatment and prevention of biofilms
GB202012326D0 (en) 2020-08-07 2020-09-23 Citryll B V Diagnostic
EP4085973A1 (en) 2021-05-04 2022-11-09 Citryll B.V. Inhibition of eosinophil extracellular traps
IL308223A (en) * 2021-05-04 2024-01-01 Citryll B V Inhibition of eosinophilic traps
EP4442705A1 (en) 2023-04-03 2024-10-09 Citryll B.V. Dosage
GB202318703D0 (en) 2023-12-07 2024-01-24 Citryll B V Diagnostic agent

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2013513374A (ja) 2009-12-10 2013-04-22 モディクエスト べー． フェー． シトルリン化エピトープに対する抗炎症剤
JP2018502903A (ja) 2014-12-11 2018-02-01 モディクエスト べー．フェー．Ｍｏｄｉｑｕｅｓｔ Ｂ．Ｖ． 特発性肺線維症の治療方法
JP2018523827A (ja) 2015-08-06 2018-08-23 ノビミューン エスアー Ｔｌｒ４依存性障害の診断および処置のための患者集団を特定するための方法および組成物

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KR20140053410A (ko) 2005-08-19 2014-05-07 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
EP2535350B1 (en) 2007-09-26 2018-01-24 UCB Biopharma SPRL Dual specificity antibody fusions
EP2294086B1 (en) * 2008-06-04 2017-09-13 ModiQuest B.V. Anti-inflammatory agents
US10407513B2 (en) 2008-09-26 2019-09-10 Ucb Biopharma Sprl Biological products
WO2011030107A1 (en) 2009-09-10 2011-03-17 Ucb Pharma S.A. Multivalent antibodies
GB201410520D0 (en) * 2014-06-12 2014-07-30 Univ London Queen Mary Antibody
LT3841120T (lt) 2018-08-21 2025-11-10 Antikūnai, surišantys citrulinuotą histoną 2a ir (arba) 4
IL308223A (en) 2021-05-04 2024-01-01 Citryll B V Inhibition of eosinophilic traps
CN117396221A (zh) * 2021-05-04 2024-01-12 奇特里尔私人有限公司 嗜酸性粒细胞陷阱的抑制

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2013513374A (ja) 2009-12-10 2013-04-22 モディクエスト べー． フェー． シトルリン化エピトープに対する抗炎症剤
JP2018502903A (ja) 2014-12-11 2018-02-01 モディクエスト べー．フェー．Ｍｏｄｉｑｕｅｓｔ Ｂ．Ｖ． 特発性肺線維症の治療方法
JP2018523827A (ja) 2015-08-06 2018-08-23 ノビミューン エスアー Ｔｌｒ４依存性障害の診断および処置のための患者集団を特定するための方法および組成物

Non-Patent Citations (1)

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Title
PATEL, C.N., et al.，"N+1 engineering of an aspartate isomerization hotspot in the complementarity-determing region of a monoclonal antibody."，JOURNAL OF PHARM. SCI.，2016年，Vol.105，pp.512-518，DOI: 10.1016/S0022-3549(15)00185-9

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SMT202500388T1 (it) 2025-11-10
KR102871821B1 (ko) 2025-10-16
US20210403543A1 (en) 2021-12-30
RS67385B1 (sr) 2025-11-28
EP3841120B1 (en) 2025-09-24
SG11202101652PA (en) 2021-03-30
EP3841120A1 (en) 2021-06-30
LT3841120T (lt) 2025-11-10
AU2026201303A1 (en) 2026-03-12
ZA202101051B (en) 2022-08-31
MX2021001902A (es) 2021-05-27
US11345750B2 (en) 2022-05-31
DK3841120T3 (da) 2025-10-20
JP2021535211A (ja) 2021-12-16
US20260176342A1 (en) 2026-06-25
US12590143B2 (en) 2026-03-31
CA3110013A1 (en) 2020-02-27
PT3841120T (pt) 2025-10-20
CN112930356A (zh) 2021-06-08
SI3841120T1 (sl) 2025-12-31
EP4659807A3 (en) 2026-03-18
WO2020038963A1 (en) 2020-02-27
IL280995A (en) 2021-04-29
HRP20251346T1 (hr) 2025-12-19
AU2026201302A1 (en) 2026-03-12
AU2019326740B2 (en) 2025-11-27
AU2019326740A1 (en) 2021-03-18
FI3841120T3 (fi) 2025-11-03
ES3048210T3 (en) 2025-12-09
CN120058926A (zh) 2025-05-30
EP4659807A2 (en) 2025-12-10
US20230183327A1 (en) 2023-06-15
IL280995B1 (en) 2025-09-01
US20210395350A1 (en) 2021-12-23
KR20210056355A (ko) 2021-05-18
JP7835788B2 (ja) 2026-03-25
CN112930356B (zh) 2025-03-21
IL280995B2 (en) 2026-01-01
MX2025007881A (es) 2025-08-01
KR20250148711A (ko) 2025-10-14
IL322482A (en) 2025-09-01
JP2024059670A (ja) 2024-05-01
MX2025007882A (es) 2025-08-01

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