CN112930356B - 与瓜氨酸化的组蛋白2a和/或4结合的抗体 - Google Patents

与瓜氨酸化的组蛋白2a和/或4结合的抗体 Download PDF

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Publication number
CN112930356B
CN112930356B CN201980070130.3A CN201980070130A CN112930356B CN 112930356 B CN112930356 B CN 112930356B CN 201980070130 A CN201980070130 A CN 201980070130A CN 112930356 B CN112930356 B CN 112930356B
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antibody
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ser
binding fragment
gly
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CN112930356A (zh
Inventor
约瑟夫·玛丽亚·亨德里克·拉茨
雷纳托·赫拉尔杜斯·西尔瓦诺·奇里维
约翰内斯·威廉姆斯·赫拉尔杜斯·范罗斯马伦
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Chitrell Private Ltd
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Chitrell Private Ltd
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Priority claimed from GBGB1813597.0A external-priority patent/GB201813597D0/en
Priority claimed from GBGB1900983.6A external-priority patent/GB201900983D0/en
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Priority to CN202510240710.XA priority Critical patent/CN120058926A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN201980070130.3A 2018-08-21 2019-08-20 与瓜氨酸化的组蛋白2a和/或4结合的抗体 Active CN112930356B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510240710.XA CN120058926A (zh) 2018-08-21 2019-08-20 与瓜氨酸化的组蛋白2a和/或4结合的抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1813597.0A GB201813597D0 (en) 2018-08-21 2018-08-21 Antibody
GB1813597.0 2018-08-21
GB1900983.6 2019-01-24
GBGB1900983.6A GB201900983D0 (en) 2019-01-24 2019-01-24 Antibody
PCT/EP2019/072302 WO2020038963A1 (en) 2018-08-21 2019-08-20 Antibodies binding to citrullinated histone 2a and/or 4

Related Child Applications (1)

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CN202510240710.XA Division CN120058926A (zh) 2018-08-21 2019-08-20 与瓜氨酸化的组蛋白2a和/或4结合的抗体

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CN112930356A CN112930356A (zh) 2021-06-08
CN112930356B true CN112930356B (zh) 2025-03-21

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CN201980070130.3A Active CN112930356B (zh) 2018-08-21 2019-08-20 与瓜氨酸化的组蛋白2a和/或4结合的抗体
CN202510240710.XA Pending CN120058926A (zh) 2018-08-21 2019-08-20 与瓜氨酸化的组蛋白2a和/或4结合的抗体

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US (3) US20210395350A1 (enExample)
EP (2) EP4659807A3 (enExample)
JP (2) JP7434328B2 (enExample)
KR (2) KR20250148711A (enExample)
CN (2) CN112930356B (enExample)
AU (3) AU2019326740B2 (enExample)
CA (1) CA3110013A1 (enExample)
DK (1) DK3841120T3 (enExample)
ES (1) ES3048210T3 (enExample)
FI (1) FI3841120T3 (enExample)
HR (1) HRP20251346T1 (enExample)
IL (2) IL322482A (enExample)
LT (1) LT3841120T (enExample)
MX (3) MX2025007881A (enExample)
PT (1) PT3841120T (enExample)
RS (1) RS67385B1 (enExample)
SG (1) SG11202101652PA (enExample)
SI (1) SI3841120T1 (enExample)
SM (1) SMT202500388T1 (enExample)
WO (1) WO2020038963A1 (enExample)
ZA (1) ZA202101051B (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
CA2993009A1 (en) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
CN112930356B (zh) 2018-08-21 2025-03-21 奇特里尔私人有限公司 与瓜氨酸化的组蛋白2a和/或4结合的抗体
WO2020072993A1 (en) 2018-10-05 2020-04-09 Research Institute At Nationwide Children's Hospital Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application
WO2021209465A1 (en) * 2020-04-14 2021-10-21 Universiteit Maastricht Peptide for the treatment of net-associated diseases
JP2023533504A (ja) * 2020-07-07 2023-08-03 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムの処置および予防のための併用療法
GB202012326D0 (en) 2020-08-07 2020-09-23 Citryll B V Diagnostic
EP4085973A1 (en) 2021-05-04 2022-11-09 Citryll B.V. Inhibition of eosinophil extracellular traps
WO2022233931A1 (en) 2021-05-04 2022-11-10 Citryll B.V. Inhibition of eosinophilic traps
EP4442705A1 (en) 2023-04-03 2024-10-09 Citryll B.V. Dosage
GB202318703D0 (en) 2023-12-07 2024-01-24 Citryll B V Diagnostic agent

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CN117396221A (zh) * 2021-05-04 2024-01-12 奇特里尔私人有限公司 嗜酸性粒细胞陷阱的抑制

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JP5364870B2 (ja) 2005-08-19 2013-12-11 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリン及びその使用
US8629246B2 (en) 2007-09-26 2014-01-14 Ucb Pharma S.A. Dual specificity antibody fusions
CN102056944A (zh) 2008-06-04 2011-05-11 莫蒂克斯特私人有限公司 抗炎症药剂
WO2010035012A1 (en) 2008-09-26 2010-04-01 Ucb Pharma S.A. Biological products
ES2667258T3 (es) 2009-09-10 2018-05-10 Ucb Biopharma Sprl Anticuerpos multivalentes
EP2332987A1 (en) 2009-12-10 2011-06-15 ModiQuest B.V. Anti-inflammatory agents directed against citrullinated epitopes
GB201410520D0 (en) * 2014-06-12 2014-07-30 Univ London Queen Mary Antibody
JP7037940B2 (ja) 2014-12-11 2022-03-17 シトリル べー．フェー． 特発性肺線維症の治療方法
WO2017021552A1 (en) 2015-08-06 2017-02-09 Novimmune Sa Methods and compositions for identifying patient populations for diagnosis and treatment of tlr4-dependent disorders
CN112930356B (zh) 2018-08-21 2025-03-21 奇特里尔私人有限公司 与瓜氨酸化的组蛋白2a和/或4结合的抗体
WO2022233931A1 (en) 2021-05-04 2022-11-10 Citryll B.V. Inhibition of eosinophilic traps

Patent Citations (1)

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Publication number Publication date
JP2021535211A (ja) 2021-12-16
RS67385B1 (sr) 2025-11-28
US20230183327A1 (en) 2023-06-15
AU2019326740A1 (en) 2021-03-18
KR20210056355A (ko) 2021-05-18
JP2024059670A (ja) 2024-05-01
MX2025007882A (es) 2025-08-01
CN120058926A (zh) 2025-05-30
ES3048210T3 (en) 2025-12-09
EP4659807A3 (en) 2026-03-18
KR20250148711A (ko) 2025-10-14
EP4659807A2 (en) 2025-12-10
US12590143B2 (en) 2026-03-31
SMT202500388T1 (it) 2025-11-10
LT3841120T (lt) 2025-11-10
US20210395350A1 (en) 2021-12-23
IL280995B2 (en) 2026-01-01
IL322482A (en) 2025-09-01
EP3841120A1 (en) 2021-06-30
IL280995A (en) 2021-04-29
ZA202101051B (en) 2022-08-31
AU2026201303A1 (en) 2026-03-12
IL280995B1 (en) 2025-09-01
HRP20251346T1 (hr) 2025-12-19
FI3841120T3 (fi) 2025-11-03
CA3110013A1 (en) 2020-02-27
KR102871821B1 (ko) 2025-10-16
DK3841120T3 (da) 2025-10-20
AU2026201302A1 (en) 2026-03-12
MX2025007881A (es) 2025-08-01
SI3841120T1 (sl) 2025-12-31
MX2021001902A (es) 2021-05-27
US11345750B2 (en) 2022-05-31
JP7835788B2 (ja) 2026-03-25
JP7434328B2 (ja) 2024-02-20
WO2020038963A1 (en) 2020-02-27
PT3841120T (pt) 2025-10-20
EP3841120B1 (en) 2025-09-24
CN112930356A (zh) 2021-06-08
SG11202101652PA (en) 2021-03-30
AU2019326740B2 (en) 2025-11-27
US20210403543A1 (en) 2021-12-30

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