JP7397123B2 - 高体積分率粒子精密濾過のための外壁集束のための装置及びその製造方法 - Google Patents
高体積分率粒子精密濾過のための外壁集束のための装置及びその製造方法 Download PDFInfo
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Description
本出願は、2016年7月21日出願のシンガポール特許出願第10201606028T号明細書からの優先権を主張する。
Claims (19)
- 精密濾過のための装置であって、
それぞれが、複数の螺旋部を含み、かつ矩形である、螺旋状矩形マイクロ流体チャネルを含む、複数の慣性マイクロ流体デバイスを含み、
前記複数の慣性マイクロ流体デバイスは、少なくとも2つの慣性マイクロ流体デバイスの1つ又は複数のグループを含み、
各グループは、
第1の慣性マイクロ流体デバイスであって、粒子の高体積分率を有する流体が前記第1の慣性マイクロ流体デバイスに入ると、粒子の精密濾過のために外壁集束を利用するように構成され、前記第1の慣性マイクロ流体デバイスが、1つの入口を2つの出口に接続する第1の螺旋状矩形マイクロ流体チャネルの第1の所定数の螺旋部を有する、第1の慣性マイクロ流体デバイスと、
第2の慣性マイクロ流体デバイスであって、粒子の精密濾過のために内壁集束を利用するように構成され、1つの入口を2つの出口に接続する第2の螺旋状矩形マイクロ流体チャネルの第2の所定数の螺旋部を有し、前記第2の螺旋状矩形マイクロ流体チャネルの前記2つの出口は、内壁集束出口及び外壁集束出口を備える、第2の慣性マイクロ流体デバイスとを備え、
前記第1の慣性マイクロ流体デバイスの前記入口は、粒子を有する未濾過の培地の入力を受け取るように構成されており、
前記第2の慣性マイクロ流体デバイスの前記入口は、前記第1の慣性マイクロ流体デバイスの前記内壁集束出口から濾過された培地の入力を受け取るように構成されており、
前記第2の慣性マイクロ流体デバイスの前記外壁集束出口からの前記濾過された培地の出力は、前記慣性マイクロ流体デバイスのグループからの出力として提供される、装置。 - 前記第1の慣性マイクロ流体デバイスの前記2つの出口のうちの第1の出口は、外壁集束出口であり、
前記2つの出口のうちの、内壁集束出口である、第2の出口の幅より大きい幅を有する、請求項1に記載の装置。 - 前記第1の慣性マイクロ流体デバイスの前記第2の出口は、前記第1の螺旋状矩形マイクロチャネルの幅の10分の1から前記第1の螺旋状矩形マイクロチャネルの幅の2分の1の幅を有する、請求項2に記載の装置。
- 前記第1の慣性マイクロ流体デバイスの前記第1の出口の幅は、前記第1の慣性マイクロ流体デバイスの螺旋状矩形マイクロ流体チャネルの幅の3分の2であり、
前記第1の慣性マイクロ流体デバイスの前記第2の出口の幅は、前記第1の螺旋状矩形マイクロ流体チャネルの幅の3分の1である、請求項2に記載の装置。 - 前記第1の慣性マイクロ流体デバイスの前記第2の出口の幅は、前記第1の螺旋状矩形マイクロ流体チャネルの幅の3分の1である、請求項3に記載の装置。
- 前記第1の慣性マイクロ流体デバイスの前記第2の出口の幅は、前記第1の螺旋状矩形マイクロ流体チャネルの幅の10分の1である、請求項3に記載の装置。
- 前記第2の慣性マイクロ流体デバイスの前記内壁集束出口の幅は、前記第2の慣性マイクロ流体デバイスの前記螺旋状矩形マイクロ流体チャネルの幅の3分の2であり、
前記第2の慣性マイクロ流体デバイスの前記外壁集束出口の幅は、前記第2の慣性マイクロ流体デバイスの前記螺旋状矩形マイクロ流体チャネルの幅の3分の1である、請求項1~6のいずれか一項に記載の装置。 - 前記第2の慣性マイクロ流体デバイスの前記外壁集束出口の幅は、前記第2の慣性マイクロ流体デバイスの前記螺旋状矩形マイクロ流体チャネルの幅の2分の1である、請求項1~6のいずれか一項に記載の装置。
- 前記第2の慣性マイクロ流体デバイスの前記外壁集束出口の幅は、前記第2の慣性マイクロ流体デバイスの前記螺旋状矩形マイクロ流体チャネルの幅の10分の1である、請求項1~6のいずれか一項に記載の装置。
- 前記流体の高体積分率精密濾過は、所定の流量での前記高体積分率精密濾過を含む、
請求項1~6のいずれか一項に記載の装置。 - 前記所定の流量は、4分の1ミリリットル/分を超える、
請求項10に記載の装置。 - 前記培地の高体積分率精密濾過は、1パーセント(1%)を超える体積分率での前記培地の高体積分率精密濾過を含む、
請求項1~6のいずれか一項に記載の装置。 - 前記培地の前記高体積分率精密濾過は、1.7%を超える体積分率での前記培地の高体積分率精密濾過を含む、
請求項12に記載の装置。 - 前記培地の前記高体積分率精密濾過は、5パーセント(5%)を超える体積分率での前記培地の高体積分率精密濾過を含む、
請求項13に記載の装置。 - 予備希釈なしの高ヘマトクリットでの血液成分を分離するためのマイクロ流体力学的現象を使用する連続的なアフェレシスデバイスを含む、請求項1~6のいずれか一項に記載の装置。
- 小容量血液遠心分離機を含む、請求項1~6のいずれか一項に記載の装置。
- 連続灌流濾過を提供するための灌流マイクロバイオリアクタを含む、請求項1~6のいずれか一項に記載の装置。
- 灌流のための粒子を含む培地の入力を受け取るように構成されたバイオリアクタと、
請求項1~17のいずれか一項に記載の装置とを含む、小規模灌流フィルタであって、
前記バイオリアクタは、1つまたは複数の慣性マイクロ流体デバイスに粒子を含む未濾過の培地の入力を提供するために、前記1つまたは複数の慣性マイクロ流体デバイスに結合され、前記粒子を含む未濾過の培地の入力は、前記バイオリアクタの灌流出力であり、
前記バイオリアクタは、粒子の1パーセント(1%)を超える体積分率を有する培地を前記第1の慣性マイクロ流体デバイスに供給し、それにより、前記第1の慣性マイクロ流体デバイスが前記バイオリアクタの前記灌流出力を、外壁集束によって、濾過して、前記培地の収穫出力を提供する、小規模灌流フィルタ。 - 前記1つ又は複数の慣性マイクロ流体デバイスは、前記培地の収穫出力を、前記バイオリアクタにフィードバックするために前記バイオリアクタにさらに結合されている、請求項18に記載の小規模灌流フィルタ。
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