JP7393808B2 - 皮膚障害の処置のためのナフチリジノン－アニリン化合物 - Google Patents

皮膚障害の処置のためのナフチリジノン－アニリン化合物 Download PDF

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JP7393808B2
JP7393808B2 JP2021527913A JP2021527913A JP7393808B2 JP 7393808 B2 JP7393808 B2 JP 7393808B2 JP 2021527913 A JP2021527913 A JP 2021527913A JP 2021527913 A JP2021527913 A JP 2021527913A JP 7393808 B2 JP7393808 B2 JP 7393808B2
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amino
mek
cycloalkyl
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ジョン キンケイド
マシュー ダンクトン
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エヌフレクション セラピューティクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021527913A 2018-11-20 2019-11-20 皮膚障害の処置のためのナフチリジノン－アニリン化合物 Active JP7393808B2 (ja)

Applications Claiming Priority (3)

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US201862769866P 2018-11-20 2018-11-20
US62/769,866 2018-11-20
PCT/US2019/000070 WO2020106308A1 (en) 2018-11-20 2019-11-20 Naphthyridinone-aniline compounds for treatment of dermal disorders

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JP2022510587A JP2022510587A (ja) 2022-01-27
JP2022510587A5 JP2022510587A5 (https=) 2022-11-18
JPWO2020106308A5 JPWO2020106308A5 (https=) 2022-11-18
JP7393808B2 true JP7393808B2 (ja) 2023-12-07

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US (1) US12378240B2 (https=)
EP (1) EP3883567B8 (https=)
JP (1) JP7393808B2 (https=)
CN (1) CN113473986B (https=)
AU (1) AU2019384646B2 (https=)
CA (1) CA3120337A1 (https=)
MA (1) MA55144A (https=)
WO (1) WO2020106308A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12466818B2 (en) 2018-11-20 2025-11-11 Nflection Therapeutics, Inc. Thienyl-aniline compounds for treatment of dermal disorders
CN113473986B (zh) 2018-11-20 2024-10-11 恩福莱克逊治疗有限公司 用于治疗皮肤疾病萘啶酮苯胺化合物
AU2019383311B2 (en) 2018-11-20 2024-12-05 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
JP2025518798A (ja) * 2022-05-30 2025-06-19 賽諾哈勃薬業（成都）有限公司 色素沈着を改善する製品を製造するためのテトラヒドロナフチリジン誘導体の使用

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Publication number Publication date
MA55144A (fr) 2021-09-29
AU2019384646B2 (en) 2025-09-18
EP3883567A1 (en) 2021-09-29
CN113473986A (zh) 2021-10-01
CN113473986B (zh) 2024-10-11
US20220144819A1 (en) 2022-05-12
WO2020106308A1 (en) 2020-05-28
EP3883567B8 (en) 2025-07-02
EP3883567A4 (en) 2022-07-27
EP3883567B1 (en) 2025-05-28
JP2022510587A (ja) 2022-01-27
CA3120337A1 (en) 2020-05-28
US12378240B2 (en) 2025-08-05
AU2019384646A1 (en) 2021-06-17

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