JP7373904B2 - セブラノパドールの滴定 - Google Patents

セブラノパドールの滴定 Download PDF

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Publication number
JP7373904B2
JP7373904B2 JP2018543634A JP2018543634A JP7373904B2 JP 7373904 B2 JP7373904 B2 JP 7373904B2 JP 2018543634 A JP2018543634 A JP 2018543634A JP 2018543634 A JP2018543634 A JP 2018543634A JP 7373904 B2 JP7373904 B2 JP 7373904B2
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cebranopadol
daily dose
days
period
dosing period
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Japanese (ja)
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JP2019507148A (ja
Inventor
ワン・シャオナン
ピアーナ・キアラ
ブルシー・ロベルタ
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パーク・セラピューティクス・インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018543634A 2016-02-29 2017-02-28 セブラノパドールの滴定 Active JP7373904B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021111672A JP2021169472A (ja) 2016-02-29 2021-07-05 セブラノパドールの滴定

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16157868.7 2016-02-29
EP16157868 2016-02-29
EP16020302 2016-08-11
EP16020302.2 2016-08-11
PCT/EP2017/025034 WO2017148595A1 (en) 2016-02-29 2017-02-28 Titration of cebranopadol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021111672A Division JP2021169472A (ja) 2016-02-29 2021-07-05 セブラノパドールの滴定

Publications (2)

Publication Number Publication Date
JP2019507148A JP2019507148A (ja) 2019-03-14
JP7373904B2 true JP7373904B2 (ja) 2023-11-06

Family

ID=58185482

Family Applications (2)

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JP2018543634A Active JP7373904B2 (ja) 2016-02-29 2017-02-28 セブラノパドールの滴定
JP2021111672A Pending JP2021169472A (ja) 2016-02-29 2021-07-05 セブラノパドールの滴定

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021111672A Pending JP2021169472A (ja) 2016-02-29 2021-07-05 セブラノパドールの滴定

Country Status (10)

Country Link
US (3) US11229625B2 (https=)
EP (1) EP3423054A1 (https=)
JP (2) JP7373904B2 (https=)
CN (2) CN109069483A (https=)
AU (1) AU2017226830B2 (https=)
BR (1) BR112018017167A2 (https=)
CA (1) CA3015420C (https=)
IL (1) IL261133A (https=)
MX (1) MX2018010367A (https=)
WO (1) WO2017148595A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339105B1 (en) 1999-10-12 2002-01-15 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
JP2006513184A (ja) 2002-12-13 2006-04-20 ユーロ−セルティーク エス．エイ． 鎮痛のためのブプレノルフィン経皮投与計画
JP2006519849A (ja) 2003-03-11 2006-08-31 ユーロ−セルティーク エス．エイ． 放出制御トラマドールの漸増投薬処方
JP2010531296A (ja) 2007-04-23 2010-09-24 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング タペンタドールの用量調節
JP2013532697A (ja) 2010-08-04 2013-08-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 神経因性疼痛の治療のための６’−フルオロ−（Ｎ−メチル−又はＮ，Ｎ−ジメチル−）−４−フェニル−４’，９’−ジヒドロ−３’Ｈ−スピロ［シクロヘキサン−１，１’−ピラノ［３，４，ｂ］インドール］−４−アミンを含む医薬剤形

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PL348808A1 (en) * 1998-11-02 2002-06-17 Ortho Mcneil Pharm Inc Analgesic regimen
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
WO2012016699A2 (en) 2010-08-04 2012-02-09 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4,9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine
WO2012016703A2 (en) 2010-08-04 2012-02-09 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
AU2011287952B2 (en) 2010-08-04 2014-08-21 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(N-methyl- or N,N-dimethyl-)-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane- 1,1'-pyrano[3,4,b]indol]-4-amine
EP2649044B1 (en) 2010-12-08 2017-09-20 Grünenthal GmbH Method for synthesising substituted aminocyclohexanone derivatives
US8614245B2 (en) 2011-07-08 2013-12-24 Gruenenthal Gmbh Crystalline (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine
CN103649094B (zh) 2011-07-08 2017-05-24 格吕伦塔尔有限公司 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺
ES2605786T3 (es) 2011-12-12 2017-03-16 Grünenthal GmbH Formas sólidas de clorhidrato de (1R,4R)-6'-fluor-N,N-dimetil-4-fenil-4',9'-dihidro-3'H-espiro[ciclohexano-1,1'-pirano[3,4b]indol]-4-amina
RS54960B1 (sr) 2011-12-12 2016-11-30 Gruenenthal Gmbh Čvrsti oblici (1r,4r)-6'-fluoro-(n,n-dimetil)-4-fenil-4',9'-dihidro-3'h-spiro-[cikloheksan-1,1'-pirano-[3,4,b]indol]-4-amina i sumporne kiseline
CN104159902B (zh) 2011-12-12 2016-05-04 格吕伦塔尔有限公司 制备(1r,4r)-6’-氟-(N,N-二甲基-和N-甲基)-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺的方法
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9308196B2 (en) 2012-05-18 2016-04-12 Gruenenthal Gmbh Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
US8912226B2 (en) 2012-05-18 2014-12-16 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR
US9320725B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
EP3110797B1 (en) 2014-02-27 2018-08-29 Grünenthal GmbH Process for the preparation of 5-fluorotryptophol
JP6673924B2 (ja) 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339105B1 (en) 1999-10-12 2002-01-15 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
JP2006513184A (ja) 2002-12-13 2006-04-20 ユーロ−セルティーク エス．エイ． 鎮痛のためのブプレノルフィン経皮投与計画
JP2006519849A (ja) 2003-03-11 2006-08-31 ユーロ−セルティーク エス．エイ． 放出制御トラマドールの漸増投薬処方
JP2010531296A (ja) 2007-04-23 2010-09-24 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング タペンタドールの用量調節
JP2013532697A (ja) 2010-08-04 2013-08-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 神経因性疼痛の治療のための６’−フルオロ−（Ｎ−メチル−又はＮ，Ｎ−ジメチル−）−４−フェニル−４’，９’−ジヒドロ−３’Ｈ−スピロ［シクロヘキサン−１，１’−ピラノ［３，４，ｂ］インドール］−４−アミンを含む医薬剤形

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ＰＨＡＲＭＡＣＯＴＨＥＲＡＰＹ，１９９９年，Ｖｏｌ．１９，Ｎｏ．１，ｐ．８８～９３

Also Published As

Publication number Publication date
CN109069483A (zh) 2018-12-21
JP2019507148A (ja) 2019-03-14
JP2021169472A (ja) 2021-10-28
IL261133A (en) 2018-10-31
CN118286209A (zh) 2024-07-05
EP3423054A1 (en) 2019-01-09
US20180369199A1 (en) 2018-12-27
CA3015420A1 (en) 2017-09-08
CA3015420C (en) 2023-09-26
US20250255849A1 (en) 2025-08-14
US11229625B2 (en) 2022-01-25
BR112018017167A2 (pt) 2019-01-02
MX2018010367A (es) 2018-12-10
AU2017226830A1 (en) 2018-08-16
US12161627B2 (en) 2024-12-10
US20220110914A1 (en) 2022-04-14
AU2017226830B2 (en) 2021-06-24
WO2017148595A1 (en) 2017-09-08

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