JP7368357B2 - バソプレシン受容体アンタゴニストならびにそれに関連する生成物および方法 - Google Patents
バソプレシン受容体アンタゴニストならびにそれに関連する生成物および方法 Download PDFInfo
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- JP7368357B2 JP7368357B2 JP2020534818A JP2020534818A JP7368357B2 JP 7368357 B2 JP7368357 B2 JP 7368357B2 JP 2020534818 A JP2020534818 A JP 2020534818A JP 2020534818 A JP2020534818 A JP 2020534818A JP 7368357 B2 JP7368357 B2 JP 7368357B2
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Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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| PCT/US2018/049607 WO2019050988A1 (en) | 2017-09-05 | 2018-09-05 | ANTAGONISTS OF THE VASOPRESSIN RECEPTOR, PRODUCTS AND RELATED METHODS |
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| CN106810536A (zh) | 2015-11-30 | 2017-06-09 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
| CA3190277A1 (en) | 2020-09-03 | 2022-03-10 | Joerg Benz | Heterocyclic compounds |
| CN117295726A (zh) * | 2021-04-23 | 2023-12-26 | 豪夫迈·罗氏有限公司 | 杂环化合物 |
| WO2023130050A1 (en) * | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Monoacylglycerol lipase inhibitors and use thereof for the treatment and management of pain |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
| US20250170100A1 (en) * | 2021-12-29 | 2025-05-29 | Psy Therapeutics, Inc. | Monoacylglycerol lipase inhibitors and use thereof for the treatment of anxiety and related conditions |
| CN120379996A (zh) * | 2022-08-11 | 2025-07-25 | 瑞敏德股份有限公司 | 用于治疗神经退行性障碍的(氮杂)螺庚烷衍生物 |
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| JP2012526154A (ja) | 2009-05-12 | 2012-10-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈｓｌ阻害薬としてのアザ環式スピロ誘導体 |
| WO2015173392A1 (en) | 2014-05-15 | 2015-11-19 | AbbVie Deutschland GmbH & Co. KG | Oxindole compounds carrying a co-bound spiro substituent and use thereof for treating vasopressin-related diseases |
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| JP2016513112A (ja) | 2013-02-18 | 2016-05-12 | ザ スクリプス リサーチ インスティテュート | 治療的潜在能力を有するバソプレッシン受容体のモジュレーター |
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| HUP0203548A3 (en) * | 1999-07-21 | 2003-04-28 | Astrazeneca Ab | New spirooxindole derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
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| DE602007006989D1 (en) * | 2006-12-07 | 2010-07-15 | Hoffmann La Roche | Spiropiperidinderivate |
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| JP2012526154A (ja) | 2009-05-12 | 2012-10-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈｓｌ阻害薬としてのアザ環式スピロ誘導体 |
| JP2016513113A (ja) | 2013-02-18 | 2016-05-12 | スプリング バンク ファーマシューティカルズ，インコーポレイテッド | ワクチンアジュバントおよび治療剤としての短鎖オリゴヌクレオチドの設計 |
| JP2016513112A (ja) | 2013-02-18 | 2016-05-12 | ザ スクリプス リサーチ インスティテュート | 治療的潜在能力を有するバソプレッシン受容体のモジュレーター |
| WO2015173392A1 (en) | 2014-05-15 | 2015-11-19 | AbbVie Deutschland GmbH & Co. KG | Oxindole compounds carrying a co-bound spiro substituent and use thereof for treating vasopressin-related diseases |
| WO2020123872A1 (en) | 2018-12-12 | 2020-06-18 | Blackthorn Therapeutics, Inc. | 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders |
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| ES2951874T3 (es) | 2023-10-25 |
| US12152038B2 (en) | 2024-11-26 |
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| ZA202104313B (en) | 2024-12-18 |
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| WO2019050988A1 (en) | 2019-03-14 |
| AU2018330423A1 (en) | 2020-03-05 |
| CN111212842B (zh) | 2022-10-25 |
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| EP3679043A1 (en) | 2020-07-15 |
| KR102765806B1 (ko) | 2025-02-10 |
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| US20210317126A1 (en) | 2021-10-14 |
| US10538530B2 (en) | 2020-01-21 |
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| MX2020002436A (es) | 2020-07-13 |
| NZ762031A (en) | 2024-04-26 |
| CA3072766A1 (en) | 2019-03-14 |
| SG11202001498QA (en) | 2020-03-30 |
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