JP7362600B2 - Ｒｉｐ１キナーゼ阻害剤として使用するための二環式化合物 - Google Patents

Ｒｉｐ１キナーゼ阻害剤として使用するための二環式化合物 Download PDF

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JP7362600B2
JP7362600B2 JP2020520532A JP2020520532A JP7362600B2 JP 7362600 B2 JP7362600 B2 JP 7362600B2 JP 2020520532 A JP2020520532 A JP 2020520532A JP 2020520532 A JP2020520532 A JP 2020520532A JP 7362600 B2 JP7362600 B2 JP 7362600B2
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fluoro
phenyl
pyrrolo
dihydro
triazole
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JP2020536915A (ja
JP2020536915A5 (enExample
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チェン，ホイフェン
ハミルトン，グレゴリー
パテル，スナヘル
ジャオ，グォイリン
ダニエルズ，ブレイク
スティバラ，クレイグ
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2020520532A 2017-10-11 2018-10-10 Ｒｉｐ１キナーゼ阻害剤として使用するための二環式化合物 Active JP7362600B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762570892P 2017-10-11 2017-10-11
US62/570,892 2017-10-11
PCT/EP2018/077656 WO2019072942A1 (en) 2017-10-11 2018-10-10 BICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF KINASE RIP1

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JP2020536915A JP2020536915A (ja) 2020-12-17
JP2020536915A5 JP2020536915A5 (enExample) 2021-11-25
JP7362600B2 true JP7362600B2 (ja) 2023-10-17

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US (1) US11673892B2 (enExample)
EP (1) EP3694858B1 (enExample)
JP (1) JP7362600B2 (enExample)
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CN (1) CN111201229B (enExample)
AU (1) AU2018348930A1 (enExample)
BR (1) BR112020007067A2 (enExample)
CA (1) CA3078653A1 (enExample)
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RU (1) RU2020114670A (enExample)
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US11071721B2 (en) 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
CN119613408A (zh) * 2017-07-14 2025-03-14 豪夫迈·罗氏有限公司 二环酮化合物及其使用方法
MX2020003451A (es) 2017-10-31 2020-08-03 Hoffmann La Roche Sulfonas y sulfoxidos biciclicos y metodos de uso de los mismos.
CN113302193B (zh) * 2019-01-11 2026-05-29 豪夫迈·罗氏有限公司 双环吡咯并三唑酮化合物及其使用方法
CN114591333B (zh) * 2020-12-04 2023-08-01 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物的制备方法
CA3214802A1 (en) * 2021-04-02 2022-10-06 Genentech, Inc. Processes for making bicyclic ketone compounds
WO2023039795A1 (zh) * 2021-09-16 2023-03-23 维泰瑞隆（北京）生物科技有限公司 Rip1激酶抑制剂及其用途
WO2025261418A1 (zh) * 2024-06-19 2025-12-26 成都赜灵生物医药科技有限公司 并芳基类化合物及其用途
WO2026001865A1 (en) * 2024-06-24 2026-01-02 Sironax Ltd. Rip1 modulators, preparations, and uses thereof

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Publication number Publication date
EP3694858B1 (en) 2023-01-11
CL2020000944A1 (es) 2020-08-21
CR20200151A (es) 2020-05-23
CN111201229A (zh) 2020-05-26
CA3078653A1 (en) 2019-04-18
AU2018348930A1 (en) 2020-03-26
SG11202003283TA (en) 2020-05-28
CO2020004977A2 (es) 2020-05-05
WO2019072942A1 (en) 2019-04-18
JP2020536915A (ja) 2020-12-17
US20200283446A1 (en) 2020-09-10
MA50356A (fr) 2021-04-21
PE20211246A1 (es) 2021-07-13
KR20200070297A (ko) 2020-06-17
PH12020550253A1 (en) 2021-02-22
EP3694858A1 (en) 2020-08-19
RU2020114670A (ru) 2021-11-12
US11673892B2 (en) 2023-06-13
CN111201229B (zh) 2024-08-23
BR112020007067A2 (pt) 2020-10-06
IL273443A (en) 2020-05-31
MX2020003439A (es) 2020-07-29

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