JP7358365B2 - がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用 - Google Patents

がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用 Download PDF

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JP7358365B2
JP7358365B2 JP2020543140A JP2020543140A JP7358365B2 JP 7358365 B2 JP7358365 B2 JP 7358365B2 JP 2020543140 A JP2020543140 A JP 2020543140A JP 2020543140 A JP2020543140 A JP 2020543140A JP 7358365 B2 JP7358365 B2 JP 7358365B2
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JP2021514945A (ja
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ベアトリス ティエン－イ ワン
ブルース アラン キート
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アイジーエム バイオサイエンシズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

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JP2020543140A 2018-02-26 2019-02-25 がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用 Active JP7358365B2 (ja)

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JP2023138517A JP2023159403A (ja) 2018-02-26 2023-08-29 がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用

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US201862635033P 2018-02-26 2018-02-26
US62/635,033 2018-02-26
US201862767900P 2018-11-15 2018-11-15
US62/767,900 2018-11-15
PCT/US2019/019340 WO2019165340A1 (en) 2018-02-26 2019-02-25 Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer

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JP2023138517A Pending JP2023159403A (ja) 2018-02-26 2023-08-29 がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用

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WO2015120474A1 (en) 2014-02-10 2015-08-13 Igm Biosciences, Inc. Iga multi-specific binding molecules
EP4011910A1 (en) 2014-04-03 2022-06-15 IGM Biosciences, Inc. Modified j-chain
PT3247728T (pt) 2015-01-20 2020-07-16 Igm Biosciences Inc Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas
KR102357312B1 (ko) 2015-03-04 2022-02-03 아이쥐엠 바이오사이언스 인코포레이티드 Ｃｄ20 결합 분자 및 그의 용도
WO2016154593A1 (en) 2015-03-25 2016-09-29 Igm Biosciences, Inc. Multi-valent hepatitis b virus antigen binding molecules and uses thereof
AU2016249404B2 (en) 2015-04-17 2021-01-21 Igm Biosciences, Inc. Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof
PT3355913T (pt) 2015-09-30 2024-12-18 Igm Biosciences Inc Moléculas de ligação com cadeia j modificada
ES2819870T3 (es) 2015-09-30 2021-04-19 Igm Biosciences Inc Moléculas de unión con cadena J modificada
WO2017196867A1 (en) 2016-05-09 2017-11-16 Igm Biosciences, Inc. Anti-pd-l1 antibodies
CA3055790A1 (en) 2017-04-07 2018-10-11 Igm Biosciences, Inc. Modified human igm constant regions for modulation of complement-dependent cytolysis effector function
CN111787951B (zh) 2018-03-01 2025-06-17 Igm生物科学股份有限公司 影响IgM血清半衰期的IgM Fc和J链突变
JP2022544405A (ja) 2019-08-15 2022-10-18 アイジーエム バイオサイエンシズ インコーポレイテッド 免疫刺激性多量体型結合分子
JP2023522962A (ja) 2020-04-22 2023-06-01 アイジーエム バイオサイエンシズ インコーポレイテッド Ｐｄ－１アゴニスト多量体結合分子
MX2022014259A (es) * 2020-05-12 2022-12-07 Igm Biosciences Inc Uso de una molecula de union anti-dr5 multimerica en combinacion con una terapia contra el cancer para tratar el cancer.
WO2022154664A1 (en) * 2021-01-15 2022-07-21 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer
US12600801B2 (en) 2022-07-11 2026-04-14 Fred Hutchinson Cancer Center Single-domain antibodies that bind ROR1

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WO2012057288A1 (ja) 2010-10-29 2012-05-03 第一三共株式会社 新規抗ｄｒ５抗体
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WO2009020093A1 (ja) 2007-08-09 2009-02-12 Daiichi Sankyo Company, Limited デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム
WO2012057288A1 (ja) 2010-10-29 2012-05-03 第一三共株式会社 新規抗ｄｒ５抗体
JP2015501291A (ja) 2011-09-26 2015-01-15 ジェイエヌ バイオサイエンシーズ エルエルシー ハイブリッド定常領域
JP2015527992A (ja) 2012-07-09 2015-09-24 アンテルナショナル−ドラック−ディベロップメント−バイオテック 抗−ｄｒ５ファミリー抗体、二重特異性又は多価の抗−ｄｒ５ファミリー抗体及びそれらの使用方法
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JP2021514945A (ja) 2021-06-17
EP3759229A1 (en) 2021-01-06
CN111757941A (zh) 2020-10-09
CA3091140A1 (en) 2019-08-29
US20200392239A1 (en) 2020-12-17
AU2019224136A1 (en) 2020-09-10
JP2023159403A (ja) 2023-10-31
KR20200123782A (ko) 2020-10-30
WO2019165340A1 (en) 2019-08-29
EP3759229A4 (en) 2021-12-29

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