JP7358236B2 - 腫瘍溶解性ウイルスを腫瘍に標的化する方法 - Google Patents

腫瘍溶解性ウイルスを腫瘍に標的化する方法 Download PDF

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JP7358236B2
JP7358236B2 JP2019515539A JP2019515539A JP7358236B2 JP 7358236 B2 JP7358236 B2 JP 7358236B2 JP 2019515539 A JP2019515539 A JP 2019515539A JP 2019515539 A JP2019515539 A JP 2019515539A JP 7358236 B2 JP7358236 B2 JP 7358236B2
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cancer
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JP2019532635A5 (enExample
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エス. モハパトラ、シャム
モハパトラ、スブーラ
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18532Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18571Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
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  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019515539A 2016-09-19 2017-09-19 腫瘍溶解性ウイルスを腫瘍に標的化する方法 Active JP7358236B2 (ja)

Applications Claiming Priority (3)

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US201662396604P 2016-09-19 2016-09-19
US62/396,604 2016-09-19
PCT/US2017/052313 WO2018053529A1 (en) 2016-09-19 2017-09-19 Method of targeting oncolytic viruses to tumors

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JP2019532635A JP2019532635A (ja) 2019-11-14
JP2019532635A5 JP2019532635A5 (enExample) 2020-10-15
JP7358236B2 true JP7358236B2 (ja) 2023-10-10

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US (2) US11607426B2 (enExample)
EP (2) EP4268838A3 (enExample)
JP (1) JP7358236B2 (enExample)
CA (1) CA3037333A1 (enExample)
WO (1) WO2018053529A1 (enExample)

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CN112004923A (zh) 2017-11-22 2020-11-27 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
CA3149478A1 (en) * 2019-08-05 2021-02-11 Mesoblast International Sarl Cellular compositions comprising viral vectors and methods of treatment
KR102233568B1 (ko) * 2019-12-13 2021-03-30 주식회사 알바이오 항암 바이러스가 도입된 중간엽 줄기세포의 세포 생존능을 향상시키는 방법
CN115996735A (zh) * 2020-08-10 2023-04-21 迈索布拉斯特国际有限公司 细胞组合物和治疗方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013529082A (ja) 2010-05-18 2013-07-18 ウエイドン、チャン 遺伝子組み換えrsウイルスを使用した乳がん治療
JP2016504324A (ja) 2012-12-14 2016-02-12 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー 幹細胞の免疫制御作用を調節する方法

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AU2006244068B9 (en) 2005-05-10 2012-10-25 Incyte Holdings Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US8685728B2 (en) * 2008-01-31 2014-04-01 Rutgers The State University Of New Jersey Kit containing stem cells and cytokines for use in attenuating immune responses
EP2291187B1 (en) 2008-04-24 2018-08-15 Newlink Genetics Corporation Ido inhibitors
SG192485A1 (en) 2008-07-08 2013-08-30 Incyte Corp 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US8722720B2 (en) 2009-10-28 2014-05-13 Newlink Genetics Corporation Imidazole derivatives as IDO inhibitors
WO2014160475A1 (en) * 2013-03-13 2014-10-02 Aboody Karen S Tropic cell based virotherapy for the treatment of cancer
WO2014159248A1 (en) 2013-03-14 2014-10-02 Newlink Genetics Corporation Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
US20160303174A1 (en) 2013-12-11 2016-10-20 The General Hospital Corporation Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013529082A (ja) 2010-05-18 2013-07-18 ウエイドン、チャン 遺伝子組み換えrsウイルスを使用した乳がん治療
JP2016504324A (ja) 2012-12-14 2016-02-12 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー 幹細胞の免疫制御作用を調節する方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
難波宏樹,幹細胞を用いた悪性グリオーマの遺伝子治療,Neuro-Oncologyの進歩,2016年04月28日,Vol. 23, No. 1,p. 21-26

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Publication number Publication date
EP4268838A2 (en) 2023-11-01
US20190216855A1 (en) 2019-07-18
EP3515462A1 (en) 2019-07-31
US11607426B2 (en) 2023-03-21
EP3515462B1 (en) 2023-06-14
US20230364147A1 (en) 2023-11-16
CA3037333A1 (en) 2018-03-22
EP3515462A4 (en) 2020-04-15
JP2019532635A (ja) 2019-11-14
EP4268838A3 (en) 2023-12-27
WO2018053529A1 (en) 2018-03-22

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