JP7341156B2 - Ａｔｒキナーゼの複素環式阻害剤 - Google Patents

Ａｔｒキナーゼの複素環式阻害剤 Download PDF

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JP7341156B2
JP7341156B2 JP2020548995A JP2020548995A JP7341156B2 JP 7341156 B2 JP7341156 B2 JP 7341156B2 JP 2020548995 A JP2020548995 A JP 2020548995A JP 2020548995 A JP2020548995 A JP 2020548995A JP 7341156 B2 JP7341156 B2 JP 7341156B2
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alkyl
heterocycloalkyl
cycloalkyl
cancer
optionally substituted
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JPWO2019178590A5 (https=
JP2021518344A (ja
JP2021518344A5 (https=
Inventor
エミリア ディ フランチェスコ マリア
ジョーンズ フィリップ
エル キャロル クリストファー
ケサヴァ ヴィジャヤン ラマスワミ スヤンブ
ジョンソン マイケル
ライブリー サラ
カン ジジュン
ラポイント デイヴィッド
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Chempartner Corp
University of Texas System
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Chempartner Corp
University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020548995A 2018-03-16 2019-03-18 Ａｔｒキナーゼの複素環式阻害剤 Active JP7341156B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862644189P 2018-03-16 2018-03-16
US62/644,189 2018-03-16
PCT/US2019/022727 WO2019178590A1 (en) 2018-03-16 2019-03-18 Heterocyclic inhibitors of atr kinase

Publications (4)

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JP2021518344A JP2021518344A (ja) 2021-08-02
JPWO2019178590A5 JPWO2019178590A5 (https=) 2022-03-22
JP2021518344A5 JP2021518344A5 (https=) 2022-03-22
JP7341156B2 true JP7341156B2 (ja) 2023-09-08

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JP2020548995A Active JP7341156B2 (ja) 2018-03-16 2019-03-18 Ａｔｒキナーゼの複素環式阻害剤

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US (1) US10894052B2 (https=)
EP (1) EP3765008B1 (https=)
JP (1) JP7341156B2 (https=)
CN (1) CN112218631B (https=)
WO (1) WO2019178590A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018218197A2 (en) 2017-05-26 2018-11-29 Board Of Regents, The University Of Texas System Tetrahydropyrido[4,3-d]pyrimidine inhibitors of atr kinase
HUE066043T2 (hu) 2017-07-13 2024-07-28 Univ Texas A TR kináz beterociklusos inhibitorai
JP7290627B2 (ja) 2017-08-17 2023-06-13 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Ａｔｒキナーゼの複素環式阻害剤
JP7341156B2 (ja) 2018-03-16 2023-09-08 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Ａｔｒキナーゼの複素環式阻害剤
WO2022094218A1 (en) * 2020-10-29 2022-05-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
IL308409A (en) * 2021-05-12 2024-01-01 Chia Tai Tianqing Pharmaceutical Group Co Ltd Sulfoximine-containing atr inhibitor compound
KR20220156468A (ko) * 2021-05-18 2022-11-25 온코닉 테라퓨틱스 주식회사 Parp 저해제 저항성 암 치료제
WO2023131234A1 (en) * 2022-01-06 2023-07-13 Shanghai Antengene Corporation Limited Crystalline forms of an atr inhibitor

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JP2010533161A (ja) 2007-07-09 2010-10-21 アストラゼネカ アクチボラグ 化合物−９４６
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JP2016539155A (ja) 2013-12-06 2016-12-15 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ＡＴＲキナーゼ阻害剤として有用な２−アミノ−６−フルオロ−Ｎ−［５−フルオロ−ピリジン−３−イル］ピラゾロ［１，５−ａ］ピリミジン−３−カルボキサミド化合物、その調製、その異なる固体形態および放射性標識された誘導体
JP2016540794A (ja) 2013-12-17 2016-12-28 ファイザー・インク ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン
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JP7159307B2 (ja) 2017-07-13 2022-10-24 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Ａｔｒキナーゼの複素環式阻害剤

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JP7290627B2 (ja) 2017-08-17 2023-06-13 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Ａｔｒキナーゼの複素環式阻害剤
JP7341156B2 (ja) 2018-03-16 2023-09-08 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Ａｔｒキナーゼの複素環式阻害剤

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US20080292588A1 (en) 2007-05-17 2008-11-27 Anadys Pharmaceuticals, Inc. 1-methyl-benzo[1,2,4]thiadiazine 1-oxide derivatives
JP2010533161A (ja) 2007-07-09 2010-10-21 アストラゼネカ アクチボラグ 化合物−９４６
JP2011526931A (ja) 2008-07-03 2011-10-20 エグゼリクシス， インコーポレイテッド Ｃｄｋモジュレーター
JP2016539155A (ja) 2013-12-06 2016-12-15 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ＡＴＲキナーゼ阻害剤として有用な２−アミノ−６−フルオロ−Ｎ−［５−フルオロ−ピリジン−３−イル］ピラゾロ［１，５−ａ］ピリミジン−３−カルボキサミド化合物、その調製、その異なる固体形態および放射性標識された誘導体
JP2016540794A (ja) 2013-12-17 2016-12-28 ファイザー・インク ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン
JP2017523987A (ja) 2014-08-04 2017-08-24 バイエル・ファルマ・アクティエンゲゼルシャフト ２−（モルホリン−４−イル）−１，７−ナフチリジン
WO2017121684A1 (en) 2016-01-14 2017-07-20 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
JP7159307B2 (ja) 2017-07-13 2022-10-24 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Ａｔｒキナーゼの複素環式阻害剤

Also Published As

Publication number Publication date
EP3765008A1 (en) 2021-01-20
CN112218631B (zh) 2023-12-22
CN112218631A (zh) 2021-01-12
US20190282584A1 (en) 2019-09-19
US10894052B2 (en) 2021-01-19
JP2021518344A (ja) 2021-08-02
EP3765008B1 (en) 2023-06-07
EP3765008A4 (en) 2021-12-08
WO2019178590A1 (en) 2019-09-19

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